| Identification |
|---|
| BMDB Protein ID
| BMDBP00108 |
| Secondary Accession Numbers
| None |
| Name
| Adenine phosphoribosyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| APRT |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. |
| Pathways
|
- AMP biosynthesis via salvage pathway
- AMP from adenine: step 1/1
- Purine Metabolism
|
| Reactions
|
| Guanosine monophosphate + Pyrophosphate → Guanine + Phosphoribosyl pyrophosphate |
details
|
| Adenosine monophosphate + Pyrophosphate → Adenine + Phosphoribosyl pyrophosphate |
details
|
| AICAR + Pyrophosphate → 5-Aminoimidazole-4-carboxamide + Phosphoribosyl pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 18 |
| Locus
| Not Available |
| SNPs
| APRT |
| Gene Sequence
|
>543 bp
ATGGCGGATCCTGAGCTGCAGCTGGTGGCGCGGCGCATCCGCAGTTTCCCCAACTTCCCC
ATCCCGGGCGTGCTGTTCAGGGACATCTCGCCCGTCCTGAAGGACCCCACCTCTTTCCGC
GCCTCCATCAACCTCCTGGCGAATCACCTGAAAAAGGCCCACGGCGGCAGGATCGACTAC
ATCGCGGGCCTAGACTCACGCGGTTTCCTGTTTGGTCCATCCCTGGCCCAGGAGCTGGGT
TTGGGCTGCATTCTCATCCGCAAGCGAGGGAAGCTGCCAGGCCCCACCGTGTGCGCCTCA
TATGCGTTGGAATACGGGAAGGGTGAACTGGAGATCCAGAGAGATGCCCTGGAACCAGGG
CAGAAGGTGGTGGTTGTGGACGACCTGCTTGCCACTGGTGGAACCATGTGCGCAGCCTGT
GAGCTGCTGGGCCAGCTGCGGGCTGAGGTGCTGGAGTGTGTAAGCCTGGTGGAGCTGACC
TCACTGAAGGGCAGGGAGAAGCTGGGGGCTGTGCCCTTCTTCTCCCTCCTGCAGTACGAG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 180 |
| Molecular Weight
| 19537.0 |
| Theoretical pI
| 7.85 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenine phosphoribosyltransferase
MADPELQLVARRIRSFPNFPIPGVLFRDISPVLKDPTSFRASINLLANHLKKAHGGRIDY
IAGLDSRGFLFGPSLAQELGLGCILIRKRGKLPGPTVCASYALEYGKGELEIQRDALEPG
QKVVVVDDLLATGGTMCAACELLGQLRAEVLECVSLVELTSLKGREKLGAVPFFSLLQYE
|
| External Links |
|---|
| GenBank ID Protein
| AAW82131.1 |
| UniProtKB/Swiss-Prot ID
| Q56JW4 |
| UniProtKB/Swiss-Prot Entry Name
| APT_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY911367 |
| GeneCard ID
| APRT |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
