| Identification |
|---|
| BMDB Protein ID
| BMDBP02830 |
| Secondary Accession Numbers
| None |
| Name
| Fibrinogen gamma-B chain |
| Synonyms
|
Not Available
|
| Gene Name
| FGG |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q12-q13 |
| SNPs
| FGG |
| Gene Sequence
|
>1335 bp
ATGAGTTGGTCCTCGCACCCTCCGAGTGTAATCTTCTACATTCTTTCATTGCTTTCTTCA
GCATGCCTGGCATATGTTGCTACCCGAGACAACTGCTGCATCTTAGATGAAAGATTTGGT
AGTTATTGCCCAACTACCTGTGGAATTGCAGATTTCCTGAATAATTACCAAACCAGTGTA
GACAAAGATCTACGAACTTTGGAAGGCATCTTATATCAGGTTGAGAACAAAACATCAGAA
GCCAGAGAGCTGGTCAAAGCAATCCAAATCAGCTATAACCCTGATCAACCATCAAAGCCA
AATAACATAGAGAGTGCTACCAAGAATTCCAAGAGTATGATGGAAGAAATTATGAAATAT
GAAACACTGATATCAACACATGAATCAACAATTCGATTTTTGCAAGAGGTATATAACTCA
AATAGTCAAAAAATCGTTAACCTAAGAGATAAAGTGGTCCAGCTTGAAGCAAACTGTCAA
GAGCCTTGTCAAGATACAGTGAAAATACATGATGTAACTGGGAGAGATTGCCAAGATGTT
GCCAATAAGGGGGCCAAAGAGAGTGGACTTTACTTTATCAGACCTCTGAAAGCTAAGCAG
TTCTTAGTCTACTGTGAAATTGATGGGTCTGGAAATGGATGGACTGTGTTTCAGAAGAGG
CTTGATGGCAGTCTGGATTTCAAGAAAAACTGGATTCAATATAAAGAAGGGTTTGGACAT
CTGTCTCCTACTGGTACTGGAAACACAGAATTTTGGCTGGGAAATGAGAAGATTCATTTG
ATAAGCACACAGTCATCCATCCCTTATGTATTAAGAATACAGTTGGAGGACTGGAATGGC
AGAACCAGCACTGCAGATTATGCTTCATTCAAGGTGACAGGTGAAAATGACAAATACCGC
CTGACATATGCTTACTTCATTGGTGGAGATGCTGGAGATGCATTTGATGGCTACGATTTT
GGCGATGATTCTAGTGACAAGTTTTTCACATCCCATAATGGCATGCAGTTCAGTACTTGG
GACAGTGACAATGATAAGTATGATGGCAACTGTGCTGAACAGGTAGGTATCGGTTGGTGG
ATGAACAAATGTCACGCTGGCCACCTCAATGGAGTTTATTATCAAGGTGGCACTTACTCA
AAAACATCTACTCCTAATGGTTATGATAATGGCATTATTTGGGCCACATGGAAATCCCGG
TGGTATTCCATGAAGAAAACCACCATGAAGATAATCCCACTTAACAGACTTGCCATCGGA
GAAGGACAGCAGCACCAACTGGGGGGAGCCAAACAGGTCGGAGTAGAACATCACGTTGAA
ATAGAATATGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 444 |
| Molecular Weight
| 50244.0 |
| Theoretical pI
| 5.62 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Fibrinogen gamma-B chain
MSWSSHPPSVIFYILSLLSSACLAYVATRDNCCILDERFGSYCPTTCGIADFLNNYQTSV
DKDLRTLEGILYQVENKTSEARELVKAIQISYNPDQPSKPNNIESATKNSKSMMEEIMKY
ETLISTHESTIRFLQEVYNSNSQKIVNLRDKVVQLEANCQEPCQDTVKIHDVTGRDCQDV
ANKGAKESGLYFIRPLKAKQFLVYCEIDGSGNGWTVFQKRLDGSLDFKKNWIQYKEGFGH
LSPTGTGNTEFWLGNEKIHLISTQSSIPYVLRIQLEDWNGRTSTADYASFKVTGENDKYR
LTYAYFIGGDAGDAFDGYDFGDDSSDKFFTSHNGMQFSTWDSDNDKYDGNCAEQVGIGWW
MNKCHAGHLNGVYYQGGTYSKTSTPNGYDNGIIWATWKSRWYSMKKTTMKIIPLNRLAIG
EGQQHQLGGAKQVGVEHHVEIEYD
|
| External Links |
|---|
| GenBank ID Protein
| CAA33562.1 |
| UniProtKB/Swiss-Prot ID
| P12799 |
| UniProtKB/Swiss-Prot Entry Name
| FIBG_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X15556 |
| GeneCard ID
| FGG |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
