<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:32:51 UTC</creation_date>
  <update_date>2020-05-20 21:07:38 UTC</update_date>
  <accession>BMDBP02713</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>DSC3</gene_name>
  <general_function>Involved in calcium ion binding</general_function>
  <specific_function>Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0000464</accession>
      <name>Calcium</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>24</chromosome_location>
    <locus>24q21-q22</locus>
    <gene_sequence>&gt;2209 bp
ACAGAAAGAGATTCTTGTGCTCCTGGAATATCAGAAGAAGGTATTGAAGAAAAGACACAC
TAAAGAAACTGTTCTCAGGCGTTCCAAAAGGAGATGGGCGCCGATACCCTGCTCGATGCA
GGAGAATTCCCTGGGACCTTTCCCCTTGTTCCTTCAACAGGTTCAATCTGATGCTGCACA
GAACTATACCATCTTCTATTCAATAAGTGGGCGTGGAGTTGACAAGGAACCTTTAAATTT
GTTTTTCATAGAAAGAGACACTGGAAATCTGTATTGTACCCAGCCTGTGGATCGTGAAGA
ATATGACGTTTTTGATCTGATTGCCTACGCGTCAACTGCAGACGGATATTCAGCAGACTT
CCCTCTCCCACTGCCCATCAGAGTGGAGGACGAAAATGACAACCATCCTATTTTCACAGA
AGCAGTTTATAATTTTGAAGTTCCGGAAAGCAGTAGAGTTGGTACTACAGTGGGAGTGGT
TTGTGCCACGGACAGAGATGAACCAGACACGATGCACACACGCCTGAAGTACAGCATTTT
GGAGCAGACACCACGATCACCTGGGCTGTTTTCTGTGCATCCCAGCACGGGTGTGATCAC
CACCGTCTCTCATTATTTGGACAGAGAGGTTGCAGACAAATACTCATTGATAATGAAAGT
ACAAGATATGGATGGCCAGTTTTTTGGATTGATGAGTACAGCGACTTGCATCATAACAGT
AAAAGATTCAAATGACAATTTGCCCACTTTCAGACAGAATGCCTATGAAGCATCAGTCGA
GGAAAACACGGTCAATGTGGAAATTCTAAGAATACCCGTAGAAGATAAGGATTTGATTAA
CACTGCCAATTGGAGAGCCAATTTTACTATTTTAAAGGGCAATGAAAATGGACATTTCAA
AATCACTACAGACAAAGCAACTAATGAAGGTGTTTTGTCTGTTGTAAAGCCACTGGATTA
TGAAGAAAGCCATCAAGTGGTCCTGGAAATTGGAGTGGCCAATGAAGCTCCATTTACTAG
AGATGTTGCACTCAGGATGACAACCATGAACAGAGCTGTGGTCACAGTTCATGTGAAGGA
TCAGGATGAAGGGCCTGAATGCAGCCCTGAAGTCCAGTATATACGGATTAAAGAAAACTC
CGCAGTGGGTTCAAAGATCAGTGGCTATAAGGCATATGACCCTGAAACTAAAAGTTCCAG
TGGTTTAAGGTACAAAATATTGCATGATCCTAAAGAGTGGATCACCGTTAATGAAGGTTC
GGGCTCATTAGAGACTTACAAAACTTTGGACAGGGAGGTTATAACTCCCAAAAATGATTT
GTATAATATTACAGTCCTGGCAATAGATCAAGATGGTAGATCATGTACTGGAACCCTCGC
AGTTAGCATTGAAGATGTGAATGATAACCCACCAGAAATACTTCAAGATTATCTAGTTAT
TTGCAAAGGAAACATGGACTATGTTGACATTTCGGCTATTGATCATGACAGTTCCATCAA
CGGTGCTCCATTTTACTTCAGCTTGGCAAACACTTCTCCAGAAATCAACAGACTATGGAC
GATCACCAGAGTTAATGATACAGCTGCCCGTCTTGCATATCAGAAAAATGCCCAATTTCA
AGAATATTTCATTCCTGTTGCTGTAAAAGACAGAGCAGGGCTATCTGCAACAAAAACCTT
GAGAGTGAACCTCTGTGATTGTACTAACCCCGTTCAATGCCGGGCTGCTCGACGGAGTGC
GGACGTGATACTTGGCAAATGGGCGATCCTTGCCATACTTCTGGGCATAGCACTACTTTT
CTCTATATTGCTAACTTTAGTATGTGGAATTGTTAGTGCCAGAAATAAAAAAGCTTTTCC
AGATGATTTGGCCCAGCAAAATCTAATTATATCAAACACAGAAGCACCTGGAGATGATAA
GGTGTGTTCTGCCAATGGGTTTATGACCCAGACAGTCAACAACGCTAACCAGGGCTTTTG
TGGCACTATGGGATCTGGAGTCAAAAACGGAGGGCAGGAAAGCATTGAAATGGTGAAAGG
AGGACAGCAGACGCTGGAGTCGTGCCGCGGGGCTGGGCATCATCACACCCTGGACTCCTG
CAGAGGAGGCACTATTGAGGTGGAGAATTCCAGATACACTTACTCCGAGTGGCAAAATTT
CACTCAACCCCGTCTTGGTGAAGAATCCATTAGAGGACACACTGGTTAA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>896</residue_number>
    <molecular_weight>99687.0</molecular_weight>
    <theoretical_pi>4.92</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
      <region>691-711</region>
    </transmembrane_regions>
    <signal_regions>
      <region>1-26</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Desmocollin-3
MAAPGSGAPCAELCRQLLLTLVVFSFACEACKKEIFNIPSKLEADKMIGRVNLKECLGSV
DRIQSSDPDFRVLEDGSVYTAHAVVLSDEKRSFTIWLSDTEKRTQKEILVLLEYQKKVLK
KRHTKETVLRRSKRRWAPIPCSMQENSLGPFPLFLQQVQSDAAQNYTIFYSISGRGVDKE
PLNLFFIERDTGNLYCTQPVDREEYDVFDLIAYASTADGYSADFPLPLPIRVEDENDNHP
IFTEAVYNFEVPESSRVGTTVGVVCATDRDEPDTMHTRLKYSILEQTPRSPGLFSVHPST
GVITTVSHYLDREVADKYSLIMKVQDMDGQFFGLMSTATCIITVKDSNDNLPTFRQNAYE
ASVEENTVNVEILRIPVEDKDLINTANWRANFTILKGNENGHFKITTDKATNEGVLSVVK
PLDYEESHQVVLEIGVANEAPFTRDVALRMTTMNRAVVTVHVKDQDEGPECSPEVQYIRI
KENSAVGSKISGYKAYDPETKSSSGLRYKILHDPKEWITVNEGSGSLETYKTLDREVITP
KNDLYNITVLAIDQDGRSCTGTLAVSIEDVNDNPPEILQDYLVICKGNMDYVDISAIDHD
SSINGAPFYFSLANTSPEINRLWTITRVNDTAARLAYQKNAQFQEYFIPVAVKDRAGLSA
TKTLRVNLCDCTNPVQCRAARRSADVILGKWAILAILLGIALLFSILLTLVCGIVSARNK
KAFPDDLAQQNLIISNTEAPGDDKVCSANGFMTQTVNNANQGFCGTMGSGVKNGGQESIE
MVKGGQQTLESCRGAGHHHTLDSCRGGTIEVENSRYTYSEWQNFTQPRLGEKLHLCNQDE
EHMPSQDYVLTYNYEGRGSPAGSVGCCSEKQEEDGLDFLNNLEAKFAALAKTCTKR</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAC41625.1</genbank_protein_id>
  <uniprot_id>Q28060</uniprot_id>
  <uniprot_name>DSC3_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>L33774</genbank_gene_id>
  <genecard_id>DSC3</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
