| Identification |
|---|
| BMDB Protein ID
| BMDBP02704 |
| Secondary Accession Numbers
| None |
| Name
| Adseverin |
| Synonyms
|
Not Available
|
| Gene Name
| SCIN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in actin filament binding |
| Specific Function
| Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane. In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+) (PubMed:1651929, PubMed:1847925, PubMed:8780652). Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (PubMed:8780652). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles (By similarity). Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| SCIN |
| Gene Sequence
|
>2148 bp
ATGGCCCAGGGGCTGTACCACGAGGAGTTCGCCCGCGCGGGCAAGCGGGCGGGGCTGCAG
GTCTGGAGAATTGAGAAGCTGGAGCTGGTGCCGGTGCCCGAGAGCGCGTATGGCAACTTC
TACGTCGGGGATGCCTACCTGGTGCTCCACACGACGCAGGCCAGCCGGGGCTTCACCTAC
CGCCTGCACTTCTGGCTGGGAAAGGAGTGTACTCAGGATGAAAGCACAGCAGCTGCCATC
TTTACTGTTCAGATGGATGACTATTTGGGTGGCAAACCTGTGCAGAACAGAGAACTTCAA
GGCTATGAGTCTACGGATTTTGTTGGCTACTTTAAAGGAGGTCTGAAATACAAGGCTGGC
GGTGTGGCGTCTGGACTCAATCATGTGCTTACAAATGACTTGACTGCTCAGAGGCTCCTG
CATGTGAAAGGTCGGAGAGTCGTCAGGGCCACGGAAGTTCCCCTAAGCTGGGACAGTTTC
AACAAGGGTGACTGCTTCATCATTGACCTTGGCACTGAAATTTACCAGTGGTGTGGATCT
TCTTGCAACAAGTACGAGCGCCTGAAGGCCAGCCAGGTTGCCATCGGCATTCGGGACAAT
GAAAGGAAAGGCAGAGCTCAGCTGATTGTGGTAGAAGAAGGGAGTGAACCATCAGAGCTT
ACAAAGGTATTAGGGGAAAAGCCAAAGCTTAGGGATGGAGAAGATGATGATGACATCAAA
GCAGATATAACTAATAGGAAAATGGCTAAACTCTACATGGTTTCAGATGCCAGTGGCTCC
ATGAAAGTGAGTCTGGTGGCAGAAGAAAACCCCTTCTCCATGGCGATGCTTCTGTCTGAA
GAATGCTTCATTTTGGACCACGGTGCTGCAAAACAGATTTTTGTATGGAAAGGTAAAGAT
GCTAATCCCCAGGAGAGAAAGGCTGCCATGAAGACAGCTGAGGAATTCCTACAGCAAATG
AATTATTCTACGAATACCCAAATTCAAGTTCTTCCAGAAGGAGGTGAAACACCAATCTTC
AAACAGTTCTTTAAGGACTGGAGAGATAGAGATCAGAGCGATGGCTTCGGGAAAGTGTAT
GTCACAGAAAAAGTGGCTCACGTAAAACAAATTCCATTTGATGCCTCAAAATTGCACAGC
TCCCCACAAATGGCAGCCCAGCATCACGTGGTGGATGACGGTTCTGGCAAAGTGCAGATT
TGGCGTGTAGAAAACAACGGTAGGGTCGAAATTGACCGAAACTCGTATGGTGAATTCTAT
GGTGGTGATTGCTACATTATACTTTACACTTATCCCAGAGGACAGATTATCTACACCTGG
CAAGGAGCAAATGCCACACGGGATGAGCTGACAACCTCCGCATTCCTGACTGTTCAGTTG
GATAGATCCCTCGGGGGACAGGCTGTGCAGATTCGAGTCTCCCAAGGCAAAGAACCTGCT
CACCTGCTGAGTTTGTTCAAAGACAAACCGCTCATTATTTACAAGAACGGAACATCAAAG
AAAGAAGGTCAGGCACCAGCCCCCCCTATACGCCTCTTTCAAGTCCGAAGAAACCTGGCT
TCGATCACCAGAATTATGGAGGTAGATGTTGATGCAAACTCATTGAATTCCAATGATGTT
TTTGTCCTGAAACTGCGACAAAATAATGGCTACATCTGGATAGGAAAAGGCTCCACACAG
GAGGAGGAGAAAGGAGCAGAGTACGTGGCAAGCGTCCTCAAATGCAAAACTTCGACGATT
CAGGAAGGCAAGGAACCAGAGGAGTTTTGGAATTCCCTTGGAGGGAAAAAAGACTACCAG
ACCTCTCCTCTGCTAGAATCCCAGGCTGAAGACCATCCACCTCGGCTTTACGGCTGCTCC
AACAAAACTGGAAGATTCATTATTGAAGAGGTTCCAGGAGAGTTCACCCAGGATGATTTA
GCAGAAGATGATGTCATGCTGTTAGATGCTTGGGAACAGATTTTTATTTGGATTGGAAAA
GATGCCAATGAAGTTGAGAAATCAGAATCTCTGAAGTCTGCCAAAATATACCTTGAGACC
GACCCTTCTGGAAGAGACAAGAGGACGCCAATTGTCATCATAAAACAGGGTCATGAGCCA
CCTACTTTCACAGGCTGGTTCCTGGGCTGGGATTCCAGCAGGTGGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 715 |
| Molecular Weight
| 80578.0 |
| Theoretical pI
| 5.73 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adseverin
MAQGLYHEEFARAGKRAGLQVWRIEKLELVPVPESAYGNFYVGDAYLVLHTTQASRGFTY
RLHFWLGKECTQDESTAAAIFTVQMDDYLGGKPVQNRELQGYESTDFVGYFKGGLKYKAG
GVASGLNHVLTNDLTAQRLLHVKGRRVVRATEVPLSWDSFNKGDCFIIDLGTEIYQWCGS
SCNKYERLKASQVAIGIRDNERKGRAQLIVVEEGSEPSELTKVLGEKPKLRDGEDDDDIK
ADITNRKMAKLYMVSDASGSMKVSLVAEENPFSMAMLLSEECFILDHGAAKQIFVWKGKD
ANPQERKAAMKTAEEFLQQMNYSTNTQIQVLPEGGETPIFKQFFKDWRDRDQSDGFGKVY
VTEKVAHVKQIPFDASKLHSSPQMAAQHHVVDDGSGKVQIWRVENNGRVEIDRNSYGEFY
GGDCYIILYTYPRGQIIYTWQGANATRDELTTSAFLTVQLDRSLGGQAVQIRVSQGKEPA
HLLSLFKDKPLIIYKNGTSKKEGQAPAPPIRLFQVRRNLASITRIMEVDVDANSLNSNDV
FVLKLRQNNGYIWIGKGSTQEEEKGAEYVASVLKCKTSTIQEGKEPEEFWNSLGGKKDYQ
TSPLLESQAEDHPPRLYGCSNKTGRFIIEEVPGEFTQDDLAEDDVMLLDAWEQIFIWIGK
DANEVEKSESLKSAKIYLETDPSGRDKRTPIVIIKQGHEPPTFTGWFLGWDSSRW
|
| External Links |
|---|
| GenBank ID Protein
| BAA05548.1 |
| UniProtKB/Swiss-Prot ID
| Q28046 |
| UniProtKB/Swiss-Prot Entry Name
| ADSV_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| D26549 |
| GeneCard ID
| SCIN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
