| Identification |
|---|
| BMDB Protein ID
| BMDBP02558 |
| Secondary Accession Numbers
| None |
| Name
| DNA-directed RNA polymerase II subunit GRINL1A |
| Synonyms
|
Not Available
|
| Gene Name
| POLR2M |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA-directed RNA polymerase activity |
| Specific Function
| Appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. May play a role in Mediator complex-dependent regulation of transcription activation. Acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| POLR2M |
| Gene Sequence
|
>1002 bp
ATGTCCTCGCTGCCCCGCGGCTTCGAGCCCCAAACTCCCGAGGACTTGGGGCAGCGGAGT
TTGGCGGAGCTACGGGAAATGTTGAAGCGCCAGGAGAGACTTTTGCGCAACGTAAAATTC
ATTTGCAAATTGCCCGACAAAGGTAAAAAGATCTCAGACGCTGTCACCAAACTGAAAGCT
GCCATCGCAGAACGTGAAGAAGTTAGAGGAAGAAGTGAACTCTTTTATCCTGTTAGCTTA
GACTGTAAGGAGAGGCAAAAAGCGATTGCAGTTGTTGATGGGGACCGAGATAAGGCCCAG
AATTCTGACCAGATACTTGACACTTCATCACCCGTTCCTGGCTGTTCCTCTGTAGCTAAC
ATCACATCATCTCAGACAACCTCACGACAACAGGGACTGGCACATCCAACTCGAGGAGGT
GATGCTGAGGCAGCTGAGGCTGAACACACAGTGAGCGAGCACCCAACTTCTAGCAGCGGA
GCCCCAGCGCCTTCCTCATCTCAAGCTAGTGAGGGTCTCCCTCAGCATTGTGCCTTAGGT
CAAGTGGAGGATCATCCTGGCAGCTCAGACAACCTGTTCATTGATAGATTACAAAGGATC
ACAATTGCGGATCCGACTGAACACCACTCAGAAGGAAACCGGAATCCTGAGAACTTGGCC
GGCCTCTGGAGTGGGCCGCAGAAGAAGCCTCATTACATGGAAGTGCTGGAAATGCGAGCC
AAAAATCCCATGCCCCCGCCACATAAATTTAAAACCAATGTATTACCTTCACAGCCCCGT
GATTCATCGAGTGCTTGTCAGAGGAGAGGGTCTCCCATCTCCTCAGAGGAGAGGCGGCGC
AGGGACAGGAAGCATCTTGATGATATCACAGCGGCCCGGCTTCTGCCGCTGCACCACCTG
CCAACCCAGCTGCTCTCCATAGAGGAGTCGCTGGCACTTCAGAGACAGCAGAAGCAGAGT
TATGAGGAGATAAGCCAAGCTCGCAGCACAGAAGCTAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 370 |
| Molecular Weight
| 41312.0 |
| Theoretical pI
| 6.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Protein GRINL1A
MSSLPRGFEPQTPEDLGQRSLAELREMLKRQERLLRNVKFICKLPDKGKKISDAVTKLKA
AIAEREEVRGRSELFYPVSLDCKERQKAIAVVDGDRDKAQNSDQILDTSSPVPGCSSVAN
ITSSQTTSRQQGLAHPTRGGDAEAAEAEHTVSEHPTSSSGAPAPSSSQASEGLPQHCALG
QVEDHPGSSDNLFIDRLQRITIADPTEHHSEGNRNPENLAGLWSGPQKKPHYMEVLEMRA
KNPMPPPHKFKTNVLPSQPRDSSSACQRRGSPISSEERRRRDRKHLDDITAARLLPLHHL
PTQLLSIEESLALQRQQKQSYEEIQAKLAAQKLAERLNIKMQSYNPEGESSRKYREVRDE
DDDQSSEDEF
|
| External Links |
|---|
| GenBank ID Protein
| AAI18413.1 |
| UniProtKB/Swiss-Prot ID
| Q17QE3 |
| UniProtKB/Swiss-Prot Entry Name
| GRL1A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC118412 |
| GeneCard ID
| POLR2M |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
