| Identification |
|---|
| BMDB Protein ID
| BMDBP02266 |
| Secondary Accession Numbers
| None |
| Name
| Sodium/calcium exchanger 1 |
| Synonyms
|
Not Available
|
| Gene Name
| SLC8A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Inorganic ion transport and metabolism |
| Specific Function
| Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1416984). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. |
| Pathways
|
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| SLC8A1 |
| Gene Sequence
|
>2913 bp
ATGCTGCAGTTCAGTCTGTCACCCACCTTGTCGATGGGATTTCACGTGATAGCCATGGTG
GCTCTCTTGTTTTCCCATGTGGACCATATAAGTGCTGAGACAGAAATGGAAGGAGAAGGC
AACGAGACTGGCGAGTGTACTGGCTCCTATTACTGTAAGAAGGGGGTGATTTTACCCATT
TGGGAGCCCCAGGACCCTTCCTTTGGAGACAAAATTGCTAGAGCGACTGTGTATTTTGTG
GCCATGGTCTACATGTTTCTTGGAGTCTCAATCATTGCTGACCGGTTCATGTCCTCTATA
GAAGTCATCACGTCTCAAGAGAAAGAAATCACCATAAAGAAACCCAATGGAGAGACCACC
AAGACAACTGTGAGGATCTGGAATGAGACAGTGTCCAACCTGACCTTGATGGCCCTGGGG
TCTTCAGCTCCAGAGATTCTCCTTTCAGTAATCGAGGTGTGTGGCCATAACTTCACTGCA
GGAGACCTTGGCCCTAGCACCATCGTGGGGAGTGCTGCATTCAACATGTTCATCATCATT
GCCCTTTGTGTGTATGTCGTCCCGGATGGGGAGACAAGGAAGATCAAGCATCTGCGTGTG
TTCTTTGTGACAGCAGCATGGAGCATCTTTGCCTATACCTGGCTTTACATCATTTTGTCT
GTCAGCTCCCCTGGGGTCGTGGAGGTCTGGGAAGGTTTGCTTACTTTCTTCTTCTTCCCC
ATCTGCGTTGTGTTTGCTTGGGTGGCAGACAGGAGGCTTCTGTTTTACAAGTATGTCTAC
AAGAGGTATCGGGCTGGCAAGCAGAGGGGAATGATTATTGAACACGAAGGAGACAGGCCA
TCTTCCAAGACAGAAATTGAAATGGATGGGAAAGTGGTCAATTCCCATGTTGACAGTTTC
TTAGATGGAGCCCTGGTTCTGGAGGTTGATGAGAGGGACCAAGATGATGAAGAAGCCAGG
CGAGAAATGGCTAGGATTCTGAAGGAACTCAAGCAGAAGCATCCAGAGAAGGAAATAGAG
CAATTAATAGAATTAGCCAATTACCAAGTCTTAAGTCAGCAGCAAAAAAGTCGAGCGTTT
TACCGTATTCAAGCTACCCGCCTGATGACCGGAGCAGGCAACATTTTAAAGAGGCATGCA
GCAGACCAAGCCAGGAAAGCTGTCAGCATGCATGAGGTCAACACGGAAGTGGCTGAAAAT
GACCCTGTCAGTAAGATCTTCTTTGAACAAGGGACATATCAGTGTCTGGAGAACTGTGGC
ACAGTAGCCCTGACCATTATCCGCAGAGGTGGTGATTTGACCAACACTGTGTTTGTTGAC
TTCAGAACAGAGGATGGCACAGCCAATGCTGGATCTGATTACGAATTTACCGAAGGAACT
GTGGTCTTTAAGCCTGGTGAGACCCAGAAGGAAATCAGAGTTGGCATCATTGATGATGAC
ATCTTTGAGGAGGATGAGAATTTCCTTGTGCATCTCAGCAACGTCAAAGTATCTTTGGAA
GCCTCGGAAGACGGCATCCTGGAAGCCAGTCATGTCTCTACCCTTGCTTGCCTGGGATCC
CCCTCCACTGCCACCGTGACTATTTTTGATGATGACCATGCTGGCATCTTTACTTTTGAG
GAACCGGTGACTCATGTGAGTGAGAGCATTGGCATCATGGAGGTGAAAGTTCTGAGAACA
TCTGGAGCACGTGGAAATGTTATCGTTCCCTATAAGACCATTGAGGGGACCGCCAGAGGT
GGAGGGGAGGACTTTGAGGACACATGCGGAGAGCTCGAGTTCCAGAATGACGAAATTGTC
AAAACAATATCAGTCAAGGTAATTGATGATGAGGAGTATGAGAAAAACAAGACCTTCTTC
CTTGAGATTGGAGAGCCCCGCCTGGTGGAGATGAGTGAGAAGAAAGCCCTGTTATTGAAT
GAGCTTGGTGGCTTCACAATAACAGGGAAATACCTGTATGGCCAGCCTGTCTTCAGGAAA
GTTCATGCTAGAGAACATCCACTCCCCTCTACTATAATCACCATCGCAGATGAATATGAT
GACAAGCAGCCACTGACCAGCAAAGAGGAGGAAGAGAGGCGCATTGCGGAAATGGGGCGC
CCCATTCTGGGAGAGCACACCAGACTGGAGGTGATCATTGAAGAATCCTACGAGTTCAAG
AGTACCGTGGACAAACTGATTAAGAAGACAAACCTAGCCCTCGTGGTTGGGACGAACAGC
TGGAGAGAGCAGTTCATCGAGGCGATCACTGTCAGTGCTGGGGAAGATGACGATGACGAC
GAATGTGGGGAGGAGAAGCTGCCCTCCTGTTTTGACTACGTGATGCACTTTCTGACTGTG
TTCTGGAAGGTCCTCTTCGCCTTTGTCCCCCCGACAGAGTACTGGAACGGCTGGGCGTGT
TTCATCGTCTCCATCCTCATGATCGGCCTACTGACGGCTTTCATTGGAGACCTCGCTTCC
CACTTCGCCTGCACCATCGCCCTGAAGGATTCCGTGACCGCGGTGGTGTTCGTTGCGCTT
GGAACCTCAGTGCCAGACACATTTGCAAGCAAAGTGGCCGCCACCCAGGACCAGTATGCG
GATGCATCCATAGGTAACGTCACAGGCAGCAACGCGGTGAACGTCTTCCTGGGCATCGGT
GTGGCCTGGTCCATCGCCGCCATCTACCACGCGGCCAACGGGGAACAGTTCAAAGTGTCC
CCTGGCACGCTAGCTTTTTCTGTCACTCTCTTCACCATTTTTGCTTTCATCAATGTGGGG
GTGCTGCTGTATCGGCGGAGGCCAGAAATTGGAGGTGAGCTGGGTGGGCCCCGGACTGCC
AAGCTCCTCACATCCTGCCTCTTTGTGCTCCTGTGGCTCTTGTACATTTTCTTCTCCTCC
CTGGAGGCCTACTGCCACATAAAAGGCTTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 970 |
| Molecular Weight
| 108027.0 |
| Theoretical pI
| 4.6 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 72-92
- 134-154
- 168-188
- 202-222
- 229-249
- 798-818
- 822-842
- 872-892
- 904-924
- 942-962
|
| Protein Sequence
|
>Sodium/calcium exchanger 1
MLQFSLSPTLSMGFHVIAMVALLFSHVDHISAETEMEGEGNETGECTGSYYCKKGVILPI
WEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETT
KTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIII
ALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVSSPGVVEVWEGLLTFFFFP
ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVDSF
LDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAF
YRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVAENDPVSKIFFEQGTYQCLENCG
TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD
IFEEDENFLVHLSNVKVSLEASEDGILEASHVSTLACLGSPSTATVTIFDDDHAGIFTFE
EPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIV
KTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLYGQPVFRK
VHAREHPLPSTIITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTRLEVIIEESYEFK
STVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTV
FWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFACTIALKDSVTAVVFVAL
GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVS
PGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSS
LEAYCHIKGF
|
| External Links |
|---|
| GenBank ID Protein
| AAA30509.1 |
| UniProtKB/Swiss-Prot ID
| P48765 |
| UniProtKB/Swiss-Prot Entry Name
| NAC1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| L06438 |
| GeneCard ID
| SLC8A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
