| Identification |
|---|
| BMDB Protein ID
| BMDBP02249 |
| Secondary Accession Numbers
| |
| Name
| 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| Synonyms
|
Not Available
|
| Gene Name
| HMGCR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Transmembrane glycoprotein that is the rate-limiting enzyme in cholesterol biosynthesis as well as in the biosynthesis of nonsterol isoprenoids that are essential for normal cell function including ubiquinone and geranylgeranyl proteins. |
| Pathways
|
- (R)-mevalonate biosynthesis
- (R)-mevalonate from acetyl-CoA: step 3/3
- Metabolic intermediate biosynthesis
|
| Reactions
|
| 3-Hydroxy-3-methylglutaryl-CoA + NADPH → Mevalonic acid + NADP + Coenzyme A |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| HMGCR |
| Gene Sequence
|
>2667 bp
ATGCTGTCAAGACTTTTCCGAATGCATGGCCTCTTCGTGGCCTCCCATCCCTGGGAAGTC
ATAGTGGGGACAGTGACGCTGACCATCTGCATGATGTCCATGAACATGTTTACTGGCAAC
AATAAGATCTGCGGTTGGAATTATGAATGTCCGAAGTTGGAAGAGGATGTTTTGAGCAGC
GACATCATAATTCTGACAATAACACGATGCATAGCAATATTGTATATTTACTTCCAGTTC
CAGAATTTACGCCAACTTGGATCAAAATATATTTTGGGTATTGCTGGACTCTTCACAATT
TTCTCCAGTTTCGTATTCAGTACAGTTGTCATTCATTTCTTAGATAAAGAATTGACAGGT
TTGAATGAAGCTTTGCCCTTTTTCCTGCTGCTGGTCGACCTTTCTAGAGCAAGTGCGCTA
GCCAAGTTCGCCCTCAGTTCTAACTCACAGGATGAAGTGAGGGAGAACATTGCTCGTGGG
ATGGCGATTTTAGGTCCCACCTTCACCCTGGATGCTCTTGTAGAATGTCTTGTGATTGGA
GTTGGTACCATGTCAGGGGTGCGTCAGCTCGAAATCATGTGCTGCTTTGGCTGCATGTCG
GTTCTCGCCAACTACTTTGTGTTCATGACTTTCTTCCCAGCTTGTGTGTCCTTGGTTCTG
GAGCTTTCTCGGGAAAGCCGCGAGGGCCGTCCAATCTGGCAGCTCAGCCATTTTGCCCGA
GTCTTAGAAGAAGAAGAAAATAAGCCAAATCCTGTTACTCAGAGGGTTAAGATGATTATG
TCTCTAGGCTTGGTTCTTGTTCACGCTCACAGTCGCTGGATAGCTGATCCTTCTCCTCAA
AACAGCACAGCAGACAATTCTAAGGTCTCTTTAGGACTGGATGAAAATGTGTCCAAGAGA
ATTGAACCGAGTGTTTCCCTCTGGCAATTTTATCTCTCTAAAATGATCAGCATGGATATT
GAACAAGTTATTACCCTAAGTTTAGCTCTCCTTCTGGCTGTCAAGTACATCTTCTTTGAA
CAAGCAGAGACAGAATCTACACTCTCGTTAAAAAATCCTATCACATCTCCTGTAGTGACC
CAAAAGAAAATCACAGACGATTGTTGTAGACGTGACCCTGTACTGGTCAGAAATGACCAG
AAATTCCATGCAATGGAGGAGGAGACCAGGAAAAACAGAGAAAGAAAAGTTGAGGTTATA
AAACCCTTACTGGCAGAAAATGACACCTCACACAGAGCCACATTCGTGGTGGGGAACTCC
TCCTTACTCGGTACTTCGCTGGAACTAGAGACACAGGAGCCTGAAATGGAACTCCCTGTG
GAGCCTCGGCCTAATGAAGAGTGTCTGCAGATTCTTGAGAATGCAGAGAAAGGTGCAAAA
TTCCTTAGTGATGCTGAGATCATCCAGTTGGTCAATGCAAAGCATATCCCAGCTTACAAA
TTGGAAACTCTGATGGAAACCCATGAGCGAGGTGTATCTATTCGCCGACAGCTACTTTCC
AAAAAACTTCCAGAGCCTTCTTCTCTCCAGTATCTACCTTACAGGGACTATAATTACTCC
TTGGTGATGGGAGCTTGCTGTGAGAACGTTATTGGATATATGCCCATCCCTGTTGGAGTG
GCAGGACCTCTGTGCTTGGATGGAAAAGAATTTCAGGTTCCAATGGCAACAACAGAAGGC
TGTCTTGTGGCCAGCACTAATAGAGGCTGCAGAGCAATAGGCCTTGGTGGAGGTGCCAGC
AGCCGAGTCCTTGCAGACGGGATGACTCGTGGCCCAGTGGTGCGTTTTCCCCGTGCTTGT
GACTCTGCAGAAGTGAAGGCCTGGCTTGAGACGCCTGAAGGGTTCACAGTGATAAAGGAA
GCCTTCGACAGCACCAGCAGGGTTGCACGTCTACAGAAACTGCATATGAGTGTGGCCGGA
CGCAACCTTTACATCCGTTTTCAGTCCAGGTCAGGTGATGCCATGGGGATGAACATGATT
TCAAAGGGTACAGAGAAAGCACTGTCCAAACTTCAGGAGTATTTCCCCGAAATGCAGATT
TTGGCCGTCAGTGGGAACTATTGTACAGACAAGAAACCTGCGGCCATCAACTGGATAGAG
GGACGAGGAAAGTCTGTGGTCTGTGAAGCTGTCATTCCAGCCAAGGTTGTCAGAGAAGTA
TTAAAGACTACAACAGAGGCTATGATTGAGGTCAACATTAATAAAAACCTGGTGGGCTCT
GCCATGGCTGGGAGCATCGGCGGCTACAACGCCCACGCAGCGAACATTGTAACTGCCATC
TACATTGCCTGTGGACAGGATGCAGCACAGAATGTTGGTAGTTCGAACTGTATTACTTTA
ATGGAAGCAAGCGGTCCCACGAACGAAGACCTGTACATCAGCTGCACCATGCCATCTATA
GAAATAGGAACCGTGGGCGGGGGCACCAACTTGCTGCCTCAGCAGGCCTGCCTGCAGATG
CTAGGCGTCCAAGGAGCATGCAGAGACAACCCCGGGGAAAATGCGCGGCAGCTGGCCCGA
ATCGTGTGCGGCACGGTGATGGCTGGGGAGCTGTCTCTGATGGCAGCACTGGCAGCAGGC
CATCTGGTCAGAAGTCACATGATTCACAACAGGTCAAAGATAAATTTGCAAGACCTCCAA
GGAACTTGCACTAAGAAGGCAGCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 888 |
| Molecular Weight
| 97727.0 |
| Theoretical pI
| 6.66 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 11-31
- 58-78
- 91-111
- 125-145
- 161-181
- 192-212
- 320-340
- 841-861
|
| Protein Sequence
|
>HMGCR protein
MLSRLFRMHGLFVASHPWEVIVGTVTLTICMMSMNMFTGNNKICGWNYECPKLEEDVLSS
DIIILTITRCIAILYIYFQFQNLRQLGSKYILGIAGLFTIFSSFVFSTVVIHFLDKELTG
LNEALPFFLLLVDLSRASALAKFALSSNSQDEVRENIARGMAILGPTFTLDALVECLVIG
VGTMSGVRQLEIMCCFGCMSVLANYFVFMTFFPACVSLVLELSRESREGRPIWQLSHFAR
VLEEEENKPNPVTQRVKMIMSLGLVLVHAHSRWIADPSPQNSTADNSKVSLGLDENVSKR
IEPSVSLWQFYLSKMISMDIEQVITLSLALLLAVKYIFFEQAETESTLSLKNPITSPVVT
QKKITDDCCRRDPVLVRNDQKFHAMEEETRKNRERKVEVIKPLLAENDTSHRATFVVGNS
SLLGTSLELETQEPEMELPVEPRPNEECLQILENAEKGAKFLSDAEIIQLVNAKHIPAYK
LETLMETHERGVSIRRQLLSKKLPEPSSLQYLPYRDYNYSLVMGACCENVIGYMPIPVGV
AGPLCLDGKEFQVPMATTEGCLVASTNRGCRAIGLGGGASSRVLADGMTRGPVVRFPRAC
DSAEVKAWLETPEGFTVIKEAFDSTSRVARLQKLHMSVAGRNLYIRFQSRSGDAMGMNMI
SKGTEKALSKLQEYFPEMQILAVSGNYCTDKKPAAINWIEGRGKSVVCEAVIPAKVVREV
LKTTTEAMIEVNINKNLVGSAMAGSIGGYNAHAANIVTAIYIACGQDAAQNVGSSNCITL
MEASGPTNEDLYISCTMPSIEIGTVGGGTNLLPQQACLQMLGVQGACRDNPGENARQLAR
IVCGTVMAGELSLMAALAAGHLVRSHMIHNRSKINLQDLQGTCTKKAA
|
| External Links |
|---|
| GenBank ID Protein
| AAI53263.1 |
| UniProtKB/Swiss-Prot ID
| A7Z064 |
| UniProtKB/Swiss-Prot Entry Name
| HMDH_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| DAAA02027738 |
| GeneCard ID
| HMGCR |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
