| Identification |
|---|
| BMDB Protein ID
| BMDBP01967 |
| Secondary Accession Numbers
| None |
| Name
| Receptor for retinol uptake STRA6 |
| Synonyms
|
Not Available
|
| Gene Name
| STRA6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Functions as retinol transporter. Accepts all-trans retinol from the extracellular retinol-binding protein RBP4, facilitates retinol transport across the cell membrane, and then transfers retinol to the cytoplasmic retinol-binding protein RBP1 (PubMed:17255476, PubMed:18419130). Retinol uptake is enhanced by LRAT, an enzyme that converts retinol to all-trans retinyl esters, the storage forms of vitamin A. Contributes to the activation of a signaling cascade that depends on retinol transport and LRAT-dependent generation of retinol metabolites that then trigger activation of JAK2 and its target STAT5, and ultimately increase the expression of SOCS3 and inhibit cellular responses to insulin. Important for the homeostasis of vitamin A and its derivatives, such as retinoic acid. STRA6-mediated transport is particularly important in the eye, and under conditions of dietary vitamin A deficiency. Does not transport retinoic acid (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| STRA6 |
| Gene Sequence
|
>2007 bp
ATGTCCACCCAGGCGGCAGGGAACCAGACCTCCTCCGGGGCCACTGACAGCGAGGATTCC
TATGACAGCTGGTACATCGACGAGCCCCAGGGTGGCCAGGAGCTCCAGCCCGAGGGGCTG
GTCCCCTCCTGCCAGCCCAATGTGCCACCCAGCCTCTACCACACCTGCCTGGCCGTGCTG
TCGATCCTCGTGTTGTTTCTGCTGGCCATGCTGGTGAGGCGCCGCCAGCTCTGGCCCCGC
TGTGGGCATGGCAGGCCCGGGCTGCCCAGCCCTGTGGATTTCTTGACTGGGGACAGGCCC
CGGACCGTGCCTGCCGCTGTCTTCATGGTCCTCTTCAGCTCCCTGTGCCTGCTGCTCCCC
ACCGAGGACCCGCTGCCTTTCCTGAGCCTCGCCTCACCACCCGGCCGAGATGGGGAAGCT
GAGACTTCAAGAGGGCCTTGGAAGATACTGGCTCTGCTGTATTACCCTGCCCTCTACTAT
CCGCTGGCTGCCTGTGCCACCGTCAGGCATGGAGCCGCCCACCTGCTCGGCAGCCTGCTG
TCCTGGGCTCATCTGGGGGTCCAGGTCTGGCAAAGGGCAGAGTGTCCTGAGTCACCCAAG
ATTTACAAGTACTACTCCCTGTTGGCCTCGCTGCCTCTCCTTCTGGGCCTCGGATTCCTG
AGCCTTTGGTACCCAGTGCAGCTGGTGAGAAGCTTCGGTCACGGGGCAGCCACGGGTTCC
AAGGGGCTGCAGAGCAGCTACTCTGAAGAATATCTGAGGACCCTCCTTTGCCAGAAGAAG
CTGAAAAGCAGCTCCCACACCTGCAAGCGTGGCTTCGCATCCCAGGCCTGGATGTACTTC
AGACACTCCGTCTACATTCCACAACGAGGATTCCGACTCCCCCTGAAGCTGGTGCTCTCA
GTCACCCTGACAGGGACGGCCATCTACCAGGTGGCCCTGCTGCTGCTAGTGGGCGTGGTA
CCCACCATCCAGAAGGTGAGGGCGGGGATCACCACGGACGTCTCCTACCTGCTGGCCGGC
TTTGGGATCGTGCTCTCAGAGGACAGGCAGGAGGTGGTGGAGCTGGTGAAGCACCACCTG
TGGGCTCTAGAAGTTTGCTACATCTCGGCCTTGGTGCTGTCTTGCTTGCTGACCTTCCTC
ATGCTGGTCCACTCGCTGGTGACACACAGGACCAACCTGCGAGCTCTGCACCGAGGGGGC
GCCCTGGACATAGGCCCCCTGACCCAGAGCCCCCGCCCCTCCCGCCAGGCCATATTCTGC
TGGATGAGCTTCACCGCCTACCAGACTGCTTTTACCTGCCTTGGACTCCTGGTACAGCAG
ATCCTCTTCTTCCTGGGGACCTTGACCCTGGCCTTCCTGGTGTTCATGCCCATGCTTCAC
GGCAGGAACCTCCTGCTCCTCCATTACCTGAAGTCCTCGTGGCCCTTCTGGCTGACCTTG
GCCCTGGCTGTGACCCTGCAGAACGCAGCGGCCCACTGGGCCTTCCTGGACACTCACCAT
GGACGCCCGGGGCTGACCAACCGAAGAGCACTCTATGCAGCCACCTTCCTTCTCTTCCCC
GTCAACGTGCTGGTGGGCACCATGGTGGCCGCCTGGAGAGTGCTCCTCTCTGCCCTCTAC
AATGCCGTCCACCTTGGCCGGATGGACCTCAGCCTGCTGCCGCTTAGAGCTGCCACTCTT
GACCCCGGCTACCACACATACTGCAACTTCTTGAGGATGGAGGCCAGCCAGTCACACCCA
GCTGCGACGGCCTTCTGTGCCCTGCTTCTGCGGACTCAGAGGCCCAAGCCCCGCGCGACC
CCCCAGGATGGCCTCAGACTGGGGGAGGAAGAGGAAGGGATTCAGCTGCTACAGACCAAG
GACCTGGTGGCCAAGGGAGCGGGGCCCAGGGCCCGCCAAGGCAGGGCTCGCTGGGGTCTG
GCGTACACGCTGCTGCACAACCCAGCTCTGCAGGCCTTCCGGAAGACAGCCCTGCCAGGT
GCCCGGCCCAACGGTGCCCAGCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 668 |
| Molecular Weight
| 73762.0 |
| Theoretical pI
| 9.67 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 52-72
- 102-122
- 146-166
- 170-190
- 207-227
- 297-317
- 369-389
- 424-444
- 475-495
|
| Protein Sequence
|
>Stimulated by retinoic acid gene 6 protein homolog
MSTQAAGNQTSSGATDSEDSYDSWYIDEPQGGQELQPEGLVPSCQPNVPPSLYHTCLAVL
SILVLFLLAMLVRRRQLWPRCGHGRPGLPSPVDFLTGDRPRTVPAAVFMVLFSSLCLLLP
TEDPLPFLSLASPPGRDGEAETSRGPWKILALLYYPALYYPLAACATVRHGAAHLLGSLL
SWAHLGVQVWQRAECPESPKIYKYYSLLASLPLLLGLGFLSLWYPVQLVRSFGHGAATGS
KGLQSSYSEEYLRTLLCQKKLKSSSHTCKRGFASQAWMYFRHSVYIPQRGFRLPLKLVLS
VTLTGTAIYQVALLLLVGVVPTIQKVRAGITTDVSYLLAGFGIVLSEDRQEVVELVKHHL
WALEVCYISALVLSCLLTFLMLVHSLVTHRTNLRALHRGGALDIGPLTQSPRPSRQAIFC
WMSFTAYQTAFTCLGLLVQQILFFLGTLTLAFLVFMPMLHGRNLLLLHYLKSSWPFWLTL
ALAVTLQNAAAHWAFLDTHHGRPGLTNRRALYAATFLLFPVNVLVGTMVAAWRVLLSALY
NAVHLGRMDLSLLPLRAATLDPGYHTYCNFLRMEASQSHPAATAFCALLLRTQRPKPRAT
PQDGLRLGEEEEGIQLLQTKDLVAKGAGPRARQGRARWGLAYTLLHNPALQAFRKTALPG
ARPNGAQP
|
| External Links |
|---|
| GenBank ID Protein
| ABG81428.1 |
| UniProtKB/Swiss-Prot ID
| Q0V8E7 |
| UniProtKB/Swiss-Prot Entry Name
| STRA6_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT026272 |
| GeneCard ID
| STRA6 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
