1.0 2018-05-07 22:27:41 UTC 2020-05-20 21:52:40 UTC BMDBP01593 Enzyme G3BP1 Involved in ATP binding ATP- and magnesium-dependent helicase that plays an essential role in innate immunity. Participates in the DNA-triggered cGAS/STING pathway by promoting the DNA binding and activation of CGAS. Enhances also DDX58-induced type I interferon production probably by helping DDX58 at sensing pathogenic RNA. In addition, plays an essential role in stress granule formation. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. BMDB0000547 Magnesium 7 >1398 bp ATGGTTATGGAGAAGCCTAGTCCCCTGCTGGTCGGGCGGGAATTTGTGAGACAGTATTAC ACACTGTTGAACCAGGCCCCAGACATGCTACACAGGTTTTATGGAAAGAACTCTTCTTAT GTCCATGGGGGATTGGATTCAAATGGAAAGCCAGCAGATGCTGTCTATGGACAGAAAGAA ATCCATAGGAAAGTGATGTCACAAAACTTCACCAATTGCCACACTAAGATCCGCCACGTT GATGCTCATGCTACTCTGAATGACGGTGTGGTGGTCCAGGTGATGGGCTTGCTCTCTAAT AACAACCAGGCTTTGAGGAGATTCATGCAGACCTTTGTCCTTGCTCCTGAGGGCTCTGTT GCAAATAAGTTCTATGTTCACAATGATATCTTCAGATACCAAGATGAGGTCTTTGGTGGC TTTATCACTGAACCTCAGGAGGAATCTGAAGAAGAAGTAGAGGAGCCTGAAGAAAGACAG CAGACACCTGAGGTGGTACCTGATGATTCTGGAACTTTTTATGATCAAACTGTCAGCAAT GACTTAGAAGAACATTTAGAAGAACCTGTTGCTGAACCAGAGCCTGAACCGGAACCAGAA CCAGAGCAGGAACCTGTATCTGAAGTCCAGGAGGAAAAGTCTGAGCCAGTCTTGGAAGAA ACTGCTCCTGAGGATGTTCAGAAGAGTTCTTCTCCAGCACCAGCAGACATAGCCCAGACA GTGCAGGAGGACTTGAGAACCTTTTCTTGGGCATCTGTGACCAGTAAGAACCTTCCACCC AGTGGAGCTGTTCCAGTTACTGGGATACCCCCACATGTTGTTAAAGTACCAGCTTCACAG CCTCGCCCGGAGTCTAAGCCTGAATCTCAGATTCCACTTCAGAGGCCTCAGAGGGATCAG AGGGTGCGAGAACAGCGAATAAATGTTCCTCCCCAGAGGGGACCCAGACCAGTCCGTGAA GCTGGTGAGCAAGGCGATGTGGAACCCCGAAGAATTGTGAGACACCCTGACAGTCACCAG CTCTTCATTGGCAACCTGCCTCATGAGGTGGATAAATCAGAGCTTAAAGACTTTTTTCAA AATTATGGGAATGTGGTAGAACTGCGTATTAACAGTGGTGGGAAATTACCCAATTTTGGG TTTGTTGTGTTTGATGATTCTGAGCCTGTTCAGAAGGTGCTTAGCAACAGGCCCATCATG TTCAGAGGAGAGGTCCGTCTGAACGTGGAAGAAAAGAAGACTCGAGCTGCCCGTGAAGGG GACCGCCGGGATAACCGCCTGCGGGGACCTGGAGGCCCTCGAGGTGGGCTGGGTGGTGGC ATGAGAGGCCCACCTCGTGGAGGCATGGTGCAGAAACCAGGATTTGGAGTGGGCAGGAGC ATTGCTCCAAGGCAGTGA 465 52122.0 5.21 6-31 52-72 None >Ras GTPase-activating protein-binding protein 1 MVMEKPSPLLVGREFVRQYYTLLNQAPDMLHRFYGKNSSYVHGGLDSNGKPADAVYGQKE IHRKVMSQNFTNCHTKIRHVDAHATLNDGVVVQVMGLLSNNNQALRRFMQTFVLAPEGSV ANKFYVHNDIFRYQDEVFGGFITEPQEESEEEVEEPEERQQTPEVVPDDSGTFYDQTVSN DLEEHLEEPVAEPEPEPEPEPEQEPVSEVQEEKSEPVLEETAPEDVQKSSSPAPADIAQT VQEDLRTFSWASVTSKNLPPSGAVPVTGIPPHVVKVPASQPRPESKPESQIPLQRPQRDQ RVREQRINVPPQRGPRPVREAGEQGDVEPRRIVRHPDSHQLFIGNLPHEVDKSELKDFFQ NYGNVVELRINSGGKLPNFGFVVFDDSEPVQKVLSNRPIMFRGEVRLNVEEKKTRAAREG DRRDNRLRGPGGPRGGLGGGMRGPPRGGMVQKPGFGVGRSIAPRQ AAI09646.1 Q32LC7 G3BP1_BOVIN BC109645 G3BP1