| Identification |
|---|
| BMDB Protein ID
| BMDBP01349 |
| Secondary Accession Numbers
| None |
| Name
| Vascular endothelial growth factor A |
| Synonyms
|
Not Available
|
| Gene Name
| VEGFA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cytokine activity |
| Specific Function
| Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| VEGFA |
| Gene Sequence
|
>573 bp
ATGAACTTTCTGCTCTCTTGGGTACATTGGAGCCTTGCCTTGCTGCTCTACCTTCACCAT
GCCAAGTGGTCCCAGGCTGCACCCATGGCAGAAGGAGGGCAGAAACCCCACGAAGTGGTG
AAGTTCATGGATGTCTACCAGCGCAGCTTCTGCCGTCCCATCGAGACCCTGGTGGACATC
TTCCAGGAGTACCCAGATGAGATTGAGTTCATTTTCAAGCCGTCCTGTGTGCCCCTGATG
CGGTGCGGGGGCTGCTGTAATGACGAAAGTCTGGAGTGTGTGCCCACTGAGGAGTTCAAC
ATCACCATGCAGATTATGCGGATCAAACCTCACCAAAGCCAGCACATAGGAGAGATGAGC
TTCCTACAGCATAACAAATGTGAATGCAGACCAAAGAAAGATAAAGCAAGGCAAGAAAAT
CCCTGTGGGCCTTGCTCAGAGCGGAGAAAGCATTTGTTTGTACAAGATCCGCAGACGTGT
AAATGTTCCTGCAAAAACACAGACTCGCGTTGCAAGGCGAGGCAGCTTGAGTTAAACGAA
CGTACTTGCAGATGTGACAAGCCGAGGCGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 190 |
| Molecular Weight
| 22310.0 |
| Theoretical pI
| 8.02 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 67-87
- 88-108
- 153-173
- 239-259
|
| Protein Sequence
|
>Vascular endothelial growth factor A
MNFLLSWVHWSLALLLYLHHAKWSQAAPMAEGGQKPHEVVKFMDVYQRSFCRPIETLVDI
FQEYPDEIEFIFKPSCVPLMRCGGCCNDESLECVPTEEFNITMQIMRIKPHQSQHIGEMS
FLQHNKCECRPKKDKARQENPCGPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNE
RTCRCDKPRR
|
| External Links |
|---|
| GenBank ID Protein
| AAA30502.1 |
| UniProtKB/Swiss-Prot ID
| P15691 |
| UniProtKB/Swiss-Prot Entry Name
| VEGFA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| M32976 |
| GeneCard ID
| VEGFA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
