| Identification |
|---|
| BMDB Protein ID
| BMDBP01309 |
| Secondary Accession Numbers
| None |
| Name
| Furin |
| Synonyms
|
Not Available
|
| Gene Name
| FURIN |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Posttranslational modification, protein turnover, chaperones |
| Specific Function
| Ubiquitous endoprotease within constitutive secretory pathways capable of cleavage at the RX(K/R)R consensus motif (PubMed:7806563). Mediates processing of TGFB1, an essential step in TGF-beta-1 activation (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| FURIN |
| Gene Sequence
|
>2394 bp
ATGGAGCTGAGGCCCTGGTTGTTCTGGGTGGTAGCAGCAGCGGGAGCCTTGGTCCTGCTG
GTGGCCGATGCCCGCGGAGAGAAGGTCTTCACCAACACCTGGGCCGTGCACATTCCTGGA
GGCCCAGCCGTCGCTGACCGTGTGGCACGCAAGCATGGCTTCCTCAACCTGGGCCAGATC
TTCGGTGACTATTACCACTTCTGGCATCGAGCGGTGACAAAGCGGTCCCTGTCTCCTCAC
CGCCTGGGCCACAACCGGCTGCAGCGGGAACCTCAAGTTAAGTGGCTGGAGCAGCAGGTG
GCAAAGCGACGGGCCAAACGGGACATATACCAGGAGCCCACGGACCCCAAGTTTCCCCAG
CAGTGGTACCTGTCTGGCGTCACCCAGCGGGACCTGAATGTGAAGGAGGCCTGGGCGCAG
GGCTACACGGGGCGTGGCATTGTGGTCTCTATCCTGGACGACGGCATCGAGAAGAACCAC
CCAGACTTGGCAGGCAATTATGATCCTGGGGCCAGCTTCGATGTCAATGATCAGGACCCT
GACCCCCAGCCCCGGTACACACAGATGAATGACAACAGGCATGGCACACGGTGTGCAGGA
GAGGTGGCTGCGGTGGCCAACAATGGTGTCTGTGGCGTAGGCGTGGCCTACAATGCCCGA
ATTGGAGGGGTGCGCATGCTGGATGGCGAAGTGACAGATGCCGTGGAGGCACGCTCGCTG
GGCCTGAACCCCAACCACATCCACATCTACAGTGCCAGCTGGGGCCCCGAGGACGACGGC
AAGACCGTGGATGGGCCAGCCCACCTGGCTGAGGAGGCCTTCTTCCGGGGGGTCAGCCAG
GGCCGCGGGGGTCTGGGCTCCATCTTTGTCTGGGCCTCGGGGAACGGGGGCCGGGAACAT
GACAGCTGCAATTGCGACGGCTACACCAACAGCATCTACACGCTGTCCATCAGCAGCGCC
ACACAGTTCGGCAACGTGCCCTGGTACAGTGAGGCCTGCTCGTCCACGCTGGCCACCACC
TACAGTAGTGGCAACCAGAATGAGAAGCAGATCGTGACCACTGACCTGCGGCAGAAGTGT
ACAGAGTCTCACACGGGCACCTCTGCGTTCGCCCCACTGGCAGCAGGCATCATCGCTCTC
ACCCTGGAGGCCAATAAGAACCTCACTTGGCGGGACATGCAGCACTTGGTAGTCCGGACC
TCAAAGCCAGCCCACCTCAACGCCAACGACTGGGCCACCAATGGTGTGGGCCGCAAAGTG
AGCCATTCGTACGGCTACGGGCTGTTGGACGCCGGCGCCATGGTGGCTCTGGCCCAGAAC
TGGACGACGGTGGCCCCTCAGCGGAAATGCACCATCGACATCCTCACTGAGCCCAAGGAC
ATCGGGAAGCGGCTGGAGGTGCGGAAGACCGTGACCGCCTGCCTGGGGGAGCCCAGCCAC
ATCACGCGGCTGGAGCATGCTCAGGCACGGCTCACCCTGTCCTACAACCGCCGCGGTGAC
CTTGCCATCCACCTGGTCAGCCCCATGGGCACCCGCTCCACCCTGCTGGCTGCCAGGCCA
CATGACTACTCTGCAGATGGGTTTAACGACTGGGCCTTCATGACGACCCATTCCTGGGAC
GAGGATCCCTCTGGCGAGTGGGTCTTAGAGATTGAAAACACCAGTGAAGCCAACAACTAT
GGGACACTGACCAAGTTCACCCTCGTGCTTTATGGCACGGCCCCTGAGGGTTTGCCCACA
CCCCCTGAGAGCATCGGCTGTAAGACCCTCACTTCCAGTCAGGCCTGTGTGGTGTGCGAG
GAAGGCTTCTCCTTGCACCAGAAGAACTGCGTCCAGCACTGTCCCCCAGGCTTCGCTCCC
CAAGTCCTGGACACACACTACAGCACAGAGAACGACGTGGAGATCATCCGGGCCAGCGTC
TGCACGCCCTGCCACGCCTCGTGCGCCACGTGCCAGGGCCCCGCCCCCACAGACTGCCTC
AGCTGCCCCAGCCACGCCTCCCTGGACCCGGTGGAGCAGACGTGCTCGCGCCAGAGCCAG
AGCAGCCGCGAGTCGCACCAGCAGCAGCCGCCGCCGCCCCCTCGGCCACCGCCCGCGGAG
GTAGCGACGGAGCCGCGGCTGCGGGCGGACCTGCTGCCCTCGCACCTGCCCGAGGTGGTG
GCCGGCCTCAGCTGCGCCTTCATCGTGCTGGTCTTCGTTACCGTCTTCCTGGTCCTGCAG
CTGCGCTCGGGCTTCAGCTTCCGAGGGGTGAAAGTGTACACCATGGACCGCGGCCTCATC
TCCTACAAGGGACTACCCCCTGAAGCCTGGCAGGAGGAGTGCCCGTCCGACTCAGAGGAG
GACGAGGGCCGGGGCGAGAGGACCGCCTTTATCAAAGACCAGAGCGCCCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 797 |
| Molecular Weight
| 87251.0 |
| Theoretical pI
| 6.39 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Furin
MELRPWLFWVVAAAGALVLLVADARGEKVFTNTWAVHIPGGPAVADRVARKHGFLNLGQI
FGDYYHFWHRAVTKRSLSPHRLGHNRLQREPQVKWLEQQVAKRRAKRDIYQEPTDPKFPQ
QWYLSGVTQRDLNVKEAWAQGYTGRGIVVSILDDGIEKNHPDLAGNYDPGASFDVNDQDP
DPQPRYTQMNDNRHGTRCAGEVAAVANNGVCGVGVAYNARIGGVRMLDGEVTDAVEARSL
GLNPNHIHIYSASWGPEDDGKTVDGPAHLAEEAFFRGVSQGRGGLGSIFVWASGNGGREH
DSCNCDGYTNSIYTLSISSATQFGNVPWYSEACSSTLATTYSSGNQNEKQIVTTDLRQKC
TESHTGTSAFAPLAAGIIALTLEANKNLTWRDMQHLVVRTSKPAHLNANDWATNGVGRKV
SHSYGYGLLDAGAMVALAQNWTTVAPQRKCTIDILTEPKDIGKRLEVRKTVTACLGEPSH
ITRLEHAQARLTLSYNRRGDLAIHLVSPMGTRSTLLAARPHDYSADGFNDWAFMTTHSWD
EDPSGEWVLEIENTSEANNYGTLTKFTLVLYGTAPEGLPTPPESIGCKTLTSSQACVVCE
EGFSLHQKNCVQHCPPGFAPQVLDTHYSTENDVEIIRASVCTPCHASCATCQGPAPTDCL
SCPSHASLDPVEQTCSRQSQSSRESHQQQPPPPPRPPPAEVATEPRLRADLLPSHLPEVV
AGLSCAFIVLVFVTVFLVLQLRSGFSFRGVKVYTMDRGLISYKGLPPEAWQEECPSDSEE
DEGRGERTAFIKDQSAL
|
| External Links |
|---|
| GenBank ID Protein
| CAA53569.1 |
| UniProtKB/Swiss-Prot ID
| Q28193 |
| UniProtKB/Swiss-Prot Entry Name
| FURIN_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X75956 |
| GeneCard ID
| FURIN |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
