| Identification |
|---|
| BMDB Protein ID
| BMDBP01299 |
| Secondary Accession Numbers
| None |
| Name
| Guanylyl cyclase-activating protein 1 |
| Synonyms
|
Not Available
|
| Gene Name
| GUCA1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Stimulates retinal guanylyl cyclase when free calcium ions concentration is low and inhibits guanylyl cyclase when free calcium ions concentration is elevated (PubMed:7520254, PubMed:8626484, PubMed:9651312, PubMed:26703466). This Ca(2+)-sensitive regulation of retinal guanylyl cyclase is a key event in recovery of the dark state of rod photoreceptors following light exposure (PubMed:7520254, PubMed:8626484). May be involved in cone photoreceptor light response and recovery of response in bright light (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 23 |
| Locus
| Not Available |
| SNPs
| GUCA1A |
| Gene Sequence
|
>618 bp
ATGGGGAACATTATGGACGGTAAGTCGGTGGAGGAGCTGAGCAGCACCGAGTGCCACCAG
TGGTACAAGAAGTTCATGACAGAGTGCCCCTCCGGCCAGCTCACCCTCTACGAGTTCCGC
CAGTTCTTCGGCCTCAAGAACCTGAGCCCGTGGGCCAGCCAGTACGTGGAGCAGATGTTT
GAGACCTTTGACTTCAACAAAGACGGCTACATTGATTTCATGGAGTACGTGGCGGCTCTG
AGCCTGGTCCTCAAGGGGAAGGTGGAACAGAAGCTGCGTTGGTACTTCAAGCTCTACGAC
GTGGACGGCAACGGATGCATCGACCGCGACGAGCTGCTCACCATCATCCGGGCCATCCGA
GCCATTAACCCCTGCAGCGACTCGACCATGACCGCCGAGGAGTTCACCGATACAGTGTTC
TCCAAGATTGACGTCAATGGGGATGGGGAACTCTCCCTAGAGGAGTTCATGGAGGGCGTC
CAGAAGGACCAGATGCTCTTGGACACGCTGACCCGAAGCTTGGACCTTACCCGCATTGTG
CGCAGGCTCCAGAATGGAGAGCAGGATGAGGAGGGGGCTAGCGGCAGGGAAACGGAGGCC
GCGGAGGCCGACGGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 205 |
| Molecular Weight
| 23510.0 |
| Theoretical pI
| 4.14 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Guanylyl cyclase-activating protein 1
MGNIMDGKSVEELSSTECHQWYKKFMTECPSGQLTLYEFRQFFGLKNLSPWASQYVEQMF
ETFDFNKDGYIDFMEYVAALSLVLKGKVEQKLRWYFKLYDVDGNGCIDRDELLTIIRAIR
AINPCSDSTMTAEEFTDTVFSKIDVNGDGELSLEEFMEGVQKDQMLLDTLTRSLDLTRIV
RRLQNGEQDEEGASGRETEAAEADG
|
| External Links |
|---|
| GenBank ID Protein
| AAB31698.2 |
| UniProtKB/Swiss-Prot ID
| P46065 |
| UniProtKB/Swiss-Prot Entry Name
| GUC1A_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| S74247 |
| GeneCard ID
| GUCA1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
