| Identification |
|---|
| BMDB Protein ID
| BMDBP01287 |
| Secondary Accession Numbers
| None |
| Name
| Prostaglandin reductase-3 |
| Synonyms
|
Not Available
|
| Gene Name
| ZADH2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Functions as 15-oxo-prostaglandin 13-reductase and acts on 15-keto-PGE1, 15-keto-PGE2, 15-keto-PGE1-alpha and 15-keto-PGE2-alpha with highest efficiency towards 15-keto-PGE2-alpha. Overexpression represses transcriptional activity of PPARG and inhibits adipocyte differentiation. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 24 |
| Locus
| Not Available |
| SNPs
| ZADH2 |
| Gene Sequence
|
>1134 bp
ATGCAGAGGCTGGCGCTCGCCGGGACCCGAGCCATCGTGGACATGTCGTACGCCCGCCAC
TTCCTGGACTTCCAGGGCTCGGCCATCCCTAGCAAGATGCAGAAGCTGGTGGTGACCCGG
CTGAGCCCCAACTTCCGAGAGGCCGTCACCCTGCGCCGGGACTGCCCGGTGCCCCTCCCC
GGGGACGGAGACCTCCTCGTCCGGAACCGATTTGTTGGTGTCAATGCTTCTGACATCAAC
TATTCGGCTGGCCGCTACGACCCTTCAGTCAAGACCCCCTTCGACGCAGGCTTCGAAGGT
GTCGGGGAGGTGGTGGCCTTGGGCCTCTCTGCCAGCGCTGCGTTCATGGTCGGCCAGGCT
GTGGCCTACATGGCGCCTGGTTCCTTCGCTGAGTACACAGTGGTGCCTGCCAGGGTCGCC
ATCCCAGTGCCGGGCCTGAAACCCGAGTATCTCACGCTCCTGGTGAGTGGGACCACAGCC
TACATCAGCCTGAAAGAGCTCGGGGGGCTGTCGGAAGGGAAGAAGGTCCTGGTGACCGCG
GCAGCCGGGGGCACCGGCCAGTTCGCCGTCCAGCTCGCAAAGAAGGCCAAGTGCCACGTC
ATTGGAACATGCTCTTCTGCCGAGAAGTCTGCTTTTCTGAAGTCTGTTGGCTGCGACCGC
CCCATCAACTATAACACCGAGCACGTGGGCACCGTCCTGAGGCAGGAGTACCCCCAAGGT
GTGGACGTGGTGTACGAGTCCGTCGGGGGAGCCATGTTTGACTTGGCCGTGGACGCCTTG
GCTACCCGAGGGCGCTTGATAGTCATCGGGTTCGTCTCTGGCTACCAGACTCCTACTGGC
CTGTCGCCCGTGAAAGCAGGAACACTTCCAGCCAAACTGCTGAAGAAATCTGCCAGTGTC
CAGGGCTTCTTCTTGAACCATTACCTTCCTGAGTTTCGAGGTGCCATGGACCACTTGCTC
AAGATGTATGCGGGTGGTGAGCTGGTTTGTGAGGTGGACACTGGAGGTCTGTCTGCAGAG
GGCAGGTTTACCGGCCTGGAATCGGTCTTCCGGGCCGTCGATTATATGTACATGAGAAAA
AACACTGGAAAAATTGTCGTTGAATTACCTCCCTCTGTCAACAGTAAGCTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 377 |
| Molecular Weight
| 40119.0 |
| Theoretical pI
| 9.18 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Zinc-binding alcohol dehydrogenase domain-containing protein 2
MQRLALAGTRAIVDMSYARHFLDFQGSAIPSKMQKLVVTRLSPNFREAVTLRRDCPVPLP
GDGDLLVRNRFVGVNASDINYSAGRYDPSVKTPFDAGFEGVGEVVALGLSASAAFMVGQA
VAYMAPGSFAEYTVVPARVAIPVPGLKPEYLTLLVSGTTAYISLKELGGLSEGKKVLVTA
AAGGTGQFAVQLAKKAKCHVIGTCSSAEKSAFLKSVGCDRPINYNTEHVGTVLRQEYPQG
VDVVYESVGGAMFDLAVDALATRGRLIVIGFVSGYQTPTGLSPVKAGTLPAKLLKKSASV
QGFFLNHYLPEFRGAMDHLLKMYAGGELVCEVDTGGLSAEGRFTGLESVFRAVDYMYMRK
NTGKIVVELPPSVNSKL
|
| External Links |
|---|
| GenBank ID Protein
| AAI14033.1 |
| UniProtKB/Swiss-Prot ID
| Q24K16 |
| UniProtKB/Swiss-Prot Entry Name
| PTGR3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114032 |
| GeneCard ID
| ZADH2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
