| Identification |
|---|
| BMDB Protein ID
| BMDBP01224 |
| Secondary Accession Numbers
| None |
| Name
| Dual specificity mitogen-activated protein kinase kinase 6 |
| Synonyms
|
Not Available
|
| Gene Name
| MAP2K6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. With MAP3K3/MKK3, catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in the MAP kinases p38 MAPK11, MAPK12, MAPK13 and MAPK14 and plays an important role in the regulation of cellular responses to cytokines and all kinds of stresses. Especially, MAP2K3/MKK3 and MAP2K6/MKK6 are both essential for the activation of MAPK11 and MAPK13 induced by environmental stress, whereas MAP2K6/MKK6 is the major MAPK11 activator in response to TNF. MAP2K6/MKK6 also phosphorylates and activates PAK6. The p38 MAP kinase signal transduction pathway leads to direct activation of transcription factors. Nuclear targets of p38 MAP kinase include the transcription factors ATF2 and ELK1. Within the p38 MAPK signal transduction pathway, MAP3K6/MKK6 mediates phosphorylation of STAT4 through MAPK14 activation, and is therefore required for STAT4 activation and STAT4-regulated gene expression in response to IL-12 stimulation. The pathway is also crucial for IL-6-induced SOCS3 expression and down-regulation of IL-6-mediated gene induction; and for IFNG-dependent gene transcription. Has a role in osteoclast differentiation through NF-kappa-B transactivation by TNFSF11, and in endochondral ossification and since SOX9 is another likely downstream target of the p38 MAPK pathway. MAP2K6/MKK6 mediates apoptotic cell death in thymocytes. Acts also as a regulator for melanocytes dendricity, through the modulation of Rho family GTPases (By similarity). |
| Pathways
|
- BCR Signaling Pathway
- Cadmium Induces DNA Synthesis and Proliferation in Macrophages
- CXCR4 Signaling Pathway
- EGF Signalling Pathway
- EPO Signaling Pathway
- FAS signaling pathway ( CD95 )
- Fc Epsilon Receptor I Signaling in Mast Cells
- GnRH Signaling Pathway
- Growth Hormone Signaling Pathway
- Insulin Signalling
- Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
- Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
- Ras Signaling Pathway
- T Cell Receptor Signaling Pathway
- Toll-Like Receptor Pathway 1
- Toll-Like Receptor Pathway 2
|
| Reactions
|
| Mitogen-activated protein kinase 1 → Mitogen-activated protein kinase 1 + Hydrogen phosphate |
details
|
| Mitogen-activated protein kinase 8 → Mitogen-activated protein kinase 8 + Hydrogen phosphate |
details
|
| Mitogen-activated protein kinase 11 → Mitogen-activated protein kinase 11 + Hydrogen phosphate |
details
|
| Inactive Mitogen-activated protein kinase 1 → Active Mitogen-activated protein kinase 1 |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 19 |
| Locus
| Not Available |
| SNPs
| MAP2K6 |
| Gene Sequence
|
>1005 bp
ATGTCTCAGTCGAAAGGCAAGAAGCGAAACCCTGGCCTTAAAATTCCCAAAGAAGCATTT
GAACAACCTCAGACCAGTTCCACGCCGCCGCGGGATTTAGACTCCAAAGCTTGCATTTCT
ATTGGAAATCAGAACTTTGAGGTGAAGGCGGATGACCTGGAGCCCATCGTGGAGCTGGGC
CGGGGGGCGTACGGGGTGGTGGAGAAGATGCGGCACGTGCCCAGCGAGCAGATCATGGCG
GTGAAGCGGATCCGGGCCACGGTAAACAGCCAAGAGCAGAAGCGGCTCCTGATGGATCTG
GATATCTCCATGAGGACCGTGGACTGTCCCTTCACGGTCACCTTTTACGGCGCACTCTTC
CGTGAGGGGGATGTCTGGATCTGCATGGAGCTCATGGACACGTCCCTAGATAAATTCTAC
AAACAAGTGATCGATAAAGGCCAAACAATTCCAGAGGACATCTTAGGGAAAATAGCAGTT
TCTATTGTAAAAGCCTTAGAGCATTTGCACAGTAAGCTGTCTGTCATTCACCGAGATGTC
AAGCCCTCCAACGTGCTCATCAACGCTCTGGGCCAGGTGAAGATGTGCGACTTCGGAATC
AGCGGCTACCTGGTCGACTCCGTGGCTAAAACCATCGATGCCGGATGCAAACCGTACATG
GCCCCCGAGAGAATAAACCCAGAGCTCAACCAGAAGGGATACAGCGTGAAGTCCGACATC
TGGAGTTTGGGCATCACCATGATCGAGCTGGCCATCCTCCGGTTTCCCTACGACTCGTGG
GGGACTCCTTTCCAGCAGCTCAAACAGGTGGTGGAGGAGCCGTCGCCGCAGCTGCCCGCA
GACAAGTTCTCCGAAGAGTTTGTTGACTTTACCTCACAGTGCTTGAAGAAGAATTCCAAA
GAAAGGCCAACATATCCAGAGCTTATGCAACATCCGTTTTTCACCCTACACGAATCCAAA
GCGACAGACGTGGCATCTTTTGTAAAATCAATTCTTGGAGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 334 |
| Molecular Weight
| 37578.0 |
| Theoretical pI
| 6.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Dual specificity mitogen-activated protein kinase kinase 6
MSQSKGKKRNPGLKIPKEAFEQPQTSSTPPRDLDSKACISIGNQNFEVKADDLEPIVELG
RGAYGVVEKMRHVPSEQIMAVKRIRATVNSQEQKRLLMDLDISMRTVDCPFTVTFYGALF
REGDVWICMELMDTSLDKFYKQVIDKGQTIPEDILGKIAVSIVKALEHLHSKLSVIHRDV
KPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPERINPELNQKGYSVKSDI
WSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPADKFSEEFVDFTSQCLKKNSK
ERPTYPELMQHPFFTLHESKATDVASFVKSILGD
|
| External Links |
|---|
| GenBank ID Protein
| AAX08815.1 |
| UniProtKB/Swiss-Prot ID
| Q5E9X2 |
| UniProtKB/Swiss-Prot Entry Name
| MP2K6_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT020798 |
| GeneCard ID
| MAP2K6 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
