| Identification |
|---|
| BMDB Protein ID
| BMDBP01186 |
| Secondary Accession Numbers
| None |
| Name
| Phosphatidylinositol 4-kinase beta |
| Synonyms
|
Not Available
|
| Gene Name
| PI4KB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 1-phosphatidylinositol 4-kinase activity |
| Specific Function
| Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis, possibly via its phosphorylation (By similarity). Involved in Golgi-to-plasma membrane trafficking (By similarity). |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| PI4KB |
| Gene Sequence
|
>2406 bp
ATGGGAGACACGATAGTGGAGCCTGCCCCCCTGAAGCCAACTTCTGAGCCCGCTCCCGGC
CCACCAGGGAATAATGGGGGCTCCTTGCTAAGTGTCATCACGGAGGGGGTCGGGGAGCTC
TCGGTGATTGACCCTGAGGTGGCCCAGAAGGCCTGCCAGGAGGTGCTGGAGAAAGTCAAG
CTCTTGCATGGAGGCGTGGCCATCTCTAGCAGAGGCACCCCCCTGGAGCTGGTCAATGGG
GATGGTGTGGACAGCGAGATCCGTTGCCTGGACGACCCACCCGCCCAGATAAGGGAGGAG
GAAGATGAGATGGGGGCCACGGTGGCCTCAGGCACAGCCAAGGGAGCAAGAAGGCGGCGG
CAGAACAACTCGGCCAAACAGTCTTGGCTGCTGAGGCTGTTTGAGTCGAAACTGTTTGAC
ATCTCCATGGCCATTTCATACCTGTATAACTCCAAGGAGCCTGGAGTGCAGGCCTACATT
GGCAACCGGCTCTTCTGCTTTCGTAATGAGGATGTGGACTTCTATCTGCCCCAGTTGCTT
AACATGTACATCCACATGGACGAGGACGTGGGTGATGCCATCAAGCCCTACATAGTCCAC
CGCTGCCGCCAGAGCATTAACTTTTCCCTCCAGTGTGCTCTGTTGCTGGGGGCCTACTCT
TCAGACATGCACATTTCCACTCAGCGACACTCCCGTGGGACCAAGCTACGGAAGCTGATC
CTCTCAGATGAGCTGAAGCCCGCTCACCGAAAGAGGGAGCTGCCCTCCTTGAGCCCAGCC
CCCGACACAGGGCTGTCTCCCTCTAAAAGGACCCACCAGCGCTCTAAGTCAGATGCCACC
GCCAGCATAAGTCTCAGCAGCAACTTGAAACGAACAGCCAGCAACCCTAAAGTGGAGAAT
GAGGACGAGCCCGTCAGACTGGCTCCTGAGCGAGAATTCATCAAGTCCCTGATGGCGATT
GGCAAGCGGCTGGCCACACTCCCCACCAAGGAGCAGAAGACACAGCGGCTGATCTCAGAG
CTCTCCCTGCTCAACCACAAGCTCCCTGCCCGAGTCTGGCTGCCCACTGCTGGCTTCGAC
CACCACGTGGTCCGCGTGCCCCACACCCAGGCTGTCGTCCTCAATTCTAAGGACAAGGCT
CCCTACCTGATCTATGTGGAGGTCCTCGAATGTGAAAACTTCGACACCACTAGTGTCCCC
GCCCGAATCCCCGAGAACCGAATTCGGAGCACCCGGTCTGTAGAGAACCTGCCCGAATGC
GGCATCACCCACGAGCAGCGGGCAGGCAGCTTCAGCACCGTGCCCAACTATGACAACGAT
GACGAGGCCTGGTCGGTGGATGACATAGGCGAGCTGCAGGTGGAGCTCCCTGAAGTGCAC
ACCAACAGCTGTGACAACATCTCCCAGTTCTCCGTGGACAGCATCACCAGCCAGGAAAGC
AAGGAGCCTGTGTTCATCGCAGCAGGTGACATCCGACGGCGCCTTTCAGAGCAGCTGGCT
CACACCCCCACAGCCTTCAAACGAGACCCGGAAGACCCTTCTGCAGTTGCTCTCAAAGAG
CCCTGGCAGGAGAAAGTACGGCGCATTAGAGAGGGTTCCCCCTATGGCCATCTCCCCAAT
TGGCGGCTCCTGTCAGTCATCGTCAAGTGTGGGGATGACCTTCGGCAGGAGCTGTTGGCC
TTTCAGGTGTTAAAGCAACTGCAGTCCATTTGGGAACAGGAGCGAGTACCCCTGTGGATC
AAGCCATATAAGATTCTTGTGATTTCGGCCGACAGTGGCATGATTGAACCAGTGGTCAAC
GCTGTATCCATTCACCAGGTGAAGAAGCAGTCACAGCTCTCCCTGCTCGATTACTTCCTA
CAGGAGCATGGCAGTTATACCACTGAGGCATTCCTCAGCGCCCAGCGCAATTTTGTGCAG
AGTTGTGCTGGCTACTGCTTGGGCTGCTACCTGCTGCAGGTCAAGGACAGACACAATGGG
AACATCCTGTTGGACGCAGAAGGCCACATCATCCACATCGACTTTGGCTTCATCCTATCC
AGCTCACCCCGAAACCTGGGCTTTGAGACATCAGCCTTCAAACTGACCACAGAGTTTGTG
GACGTGATGGGCGGCCTGGATGGCGACATGTTCAACTATTACAAGATGTTGATGCTGCAG
GGGCTGATCGCTGCTCGGAAACACATGGATAAGGTGGTGCAGATCGTAGAGATCATGCAA
CAAGGTTCTCAGCTTCCTTGCTTCCATGGCTCCAGCACCATCCGCAACCTCAAGGAGAGG
TTCCACATGAGCATGACCGAGGAGCAGCTGCAGCTGCTGGTGGAGCAGATGGTGGATGGC
AGCATGCGGTCTATAACCACCAAACTCTATGACGGCTTCCAGTACCTCACCAACGGCATC
ATGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 816 |
| Molecular Weight
| 91375.0 |
| Theoretical pI
| 6.2 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidylinositol 4-kinase beta
MGDTIVEPAPLKPTSEPAPGPPGNNGGSLLSVITEGVGELSVIDPEVAQKACQEVLEKVK
LLHGGVAISSRGTPLELVNGDGVDSEIRCLDDPPAQIREEEDEMGATVASGTAKGARRRR
QNNSAKQSWLLRLFESKLFDISMAISYLYNSKEPGVQAYIGNRLFCFRNEDVDFYLPQLL
NMYIHMDEDVGDAIKPYIVHRCRQSINFSLQCALLLGAYSSDMHISTQRHSRGTKLRKLI
LSDELKPAHRKRELPSLSPAPDTGLSPSKRTHQRSKSDATASISLSSNLKRTASNPKVEN
EDEELSSSTESIDNSFSSPVRLAPEREFIKSLMAIGKRLATLPTKEQKTQRLISELSLLN
HKLPARVWLPTAGFDHHVVRVPHTQAVVLNSKDKAPYLIYVEVLECENFDTTSVPARIPE
NRIRSTRSVENLPECGITHEQRAGSFSTVPNYDNDDEAWSVDDIGELQVELPEVHTNSCD
NISQFSVDSITSQESKEPVFIAAGDIRRRLSEQLAHTPTAFKRDPEDPSAVALKEPWQEK
VRRIREGSPYGHLPNWRLLSVIVKCGDDLRQELLAFQVLKQLQSIWEQERVPLWIKPYKI
LVISADSGMIEPVVNAVSIHQVKKQSQLSLLDYFLQEHGSYTTEAFLSAQRNFVQSCAGY
CLGCYLLQVKDRHNGNILLDAEGHIIHIDFGFILSSSPRNLGFETSAFKLTTEFVDVMGG
LDGDMFNYYKMLMLQGLIAARKHMDKVVQIVEIMQQGSQLPCFHGSSTIRNLKERFHMSM
TEEQLQLLVEQMVDGSMRSITTKLYDGFQYLTNGIM
|
| External Links |
|---|
| GenBank ID Protein
| AAC48729.1 |
| UniProtKB/Swiss-Prot ID
| O02810 |
| UniProtKB/Swiss-Prot Entry Name
| PI4KB_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| U88531 |
| GeneCard ID
| PI4KB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
