| Identification |
|---|
| BMDB Protein ID
| BMDBP01160 |
| Secondary Accession Numbers
| None |
| Name
| Phosphoglycerate kinase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| PGK1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. |
| Pathways
|
- Carbohydrate degradation
- Glycolysis
- Pyruvate from D-glyceraldehyde 3-phosphate: step 2/5
- Warburg Effect
|
| Reactions
|
| Glyceric acid 1,3-biphosphate + ADP → 3-Phosphoglyceric acid + Adenosine triphosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Xq25 |
| SNPs
| PGK1 |
| Gene Sequence
|
>1254 bp
ATGTCGCTTTCTAACAAGCTGACTCTGGACAAGCTGGATGTGAAGGGGAAGCGGGTCGTC
ATGAGAGTAGACTTCAATGTTCCTATGAAGAACAACCAGATAACAAACAACCAGAGGATC
AAGGCTGCTGTTCCAAGCATCAAATACTGCTTGGACAGTGGAGCCAAGTCAGTTGTTCTT
ATGAGCCACCTGGGCCGGCCTGATGGTGTCCCCATGCCTGATAAGTACTCCTTGCAGCCA
GTTGCTGTAGAACTCAAATCTCTGCTGGGCAAGGATGTTTTGTTCTTGAAGGACTGTGTG
GGCCCAGAAGTGGAGAAGGCTTGTGCTGACCCAGCTGCTGGGTCTGTCATCCTGCTGGAG
AACCTTCGTTTTCATGTGGAGGAAGAAGGGAAGGGAAAAGATGCTTCTGGGAACAAGGTT
AAAGCTGAGCCAACCAAAATAGAAGCCTTCCGAGCTTCACTTTCTAAGCTAGGGGATGTT
TATGTCAATGATGCTTTTGGCACTGCTCACCGAGCCCACAGCTCCATGGTAGGAGTAAAT
CTGCCAAAGAAGGCTGGAGGTTTTTTGATGAAGAAGGAGTTGAACTACTTTGCCAAGGCC
TTGGAGAGCCCTGAGCGACCGTTCCTGGCCATCCTGGGCGGAGCTAAAGTTGCAGACAAG
ATCCAGCTGATCAGTAATATGCTGGACAAAGTCAATGAAATGATTATTGGTGGTGGAATG
GCCTTTACCTTCCTTAAGGTGCTCAACAACATGGAGATTGGCACTTCTTTGTTTGATGAA
GAGGGATCCAAGATTGTCAAAGACCTGATGTCCAAAGCTGACAAGAATGGCGTGAAGATT
ACTTTGCCTGTTGACTTTGTCACTGCTGATAAGTTTGATGAGAATGCCAAGACTGGCCAA
GCCACTGTGGCCTCTGGCATACCTGCTGGCTGGATGGGCTTGGACTGTGGTCCTGAGAGC
AGTAAGAAGTATGCTGAGGCTGTTGCTCGGGCTAAGCAGATCGTGTGGAATGGACCTGTG
GGTGTATTTGAATGGGAAGCTTTTGCCCGAGGAACCAAAGCCCTTATGGATGAGGTGGTG
AAAGCCACTTCCAGGGGCTGCATCACCATCATAGGTGGTGGAGACACTGCTACTTGCTGT
GCCAAATGGAACACAGAGGATAAAGTCAGTCATGTGAGCACTGGGGGTGGTGCCAGTTTA
GAGCTCCTGGAAGGTAAAGTGCTTCCTGGAGTGGATGCTCTCAGCAGTGTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 417 |
| Molecular Weight
| 44538.0 |
| Theoretical pI
| 8.46 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphoglycerate kinase 1
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKYCLDSGAKSVVL
MSHLGRPDGVPMPDKYSLQPVAVELKSLLGKDVLFLKDCVGPEVEKACADPAAGSVILLE
NLRFHVEEEGKGKDASGNKVKAEPTKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVN
LPKKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLISNMLDKVNEMIIGGGM
AFTFLKVLNNMEIGTSLFDEEGSKIVKDLMSKADKNGVKITLPVDFVTADKFDENAKTGQ
ATVASGIPAGWMGLDCGPESSKKYAEAVARAKQIVWNGPVGVFEWEAFARGTKALMDEVV
KATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSSV
|
| External Links |
|---|
| GenBank ID Protein
| AAI02309.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0P6 |
| UniProtKB/Swiss-Prot Entry Name
| PGK1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102308 |
| GeneCard ID
| PGK1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
