| Identification |
|---|
| BMDB Protein ID
| BMDBP01151 |
| Secondary Accession Numbers
| |
| Name
| CTP synthase 2 |
| Synonyms
|
Not Available
|
| Gene Name
| CTPS2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). |
| Pathways
|
- CTP biosynthesis via de novo pathway
- CTP from UDP: step 2/2
- Pyrimidine Metabolism
|
| Reactions
|
| Uridine triphosphate + Adenosine triphosphate → Cytidine triphosphate + ADP + Hydrogen phosphate + dCTP |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| CTPS2 |
| Gene Sequence
|
>1761 bp
ATGAAGTACATCTTGGTCACTGGTGGGGTCATCTCGGGCATCGGTAAAGGGATCATTGCC
AGCAGTATTGGGACGATTCTAAAATCATGTGGACTCCGAGTGACTGCCATCAAAATTGAC
CCCTATATAAACATCGATGCAGGCACTTTTTCACCTTATGAGCACGGTGAAGTGTTTGTC
TTAAACGATGGTGGAGAAGTTGATTTAGACCTTGGAAATTATGAAAGGTTCTTGGATATT
AATCTTTATAAAGACAACAACATCACTACTGGGAAGATATATCAACATGTGATCAATAAA
GAGAGGCGTGGCGATTACCTGGGGAAAACAGTACAAGTTGTCCCTCACATTACTGATGCT
GTCCAGGAGTGGGTTATGAATCAAGCCATGGTGCCTGTGGATGGTCATAAGGAAGAGCCC
CAAATATGCGTTATTGAGCTGGGTGGCACCATTGGAGACATTGAAGGAATGCCGTTTGTG
GAAGCGTTCAGACAATTCCAGTTTAAAGCAAAAAGAGAGAATTTCTGTAATATTCATGTT
AGCCTTGTCCCACAGCCCAGTGCTACCGGAGAACAAAAAACCAAACCCACACAAAACAGT
GTCCGTGCGCTGAGGGGATTAGGCCTGTCTCCCGATCTGATTGTCTGCCGGAGTTCAACG
CCCATCGAAATGGCTGTGAAGGAAAAGATTTCTATGTTTTGTCATGTGAACCCTGAACAG
GTCATATGTATCCATGATGTTTCTTCCACCTACCGAGTGCCTGTGCTTTTGGAGGAACAA
GGCATCATTAAATATTTTAAAGAGAGATTGGATCTGCCCATTGGGGATTCTGCAAGTAGT
TTGCTTTCCAAGTGGAGAAATATGGCTGACAGGTATGAAAGGTTACAGAAAACATGTTCC
ATTGCCCTGGTTGGCAAATACACCAAGCTCAGGGACTGCTATGCCTCCGTGTTCAAAGCC
CTGGAACACTCAGCCTTGGCCATCAACCACAAGTTGAATCTGATGTACATAGATTCCATT
GATCTGGAGCAGACTACTGAAGTTGAAGACCCTGTGAAATTCCATGAAGCTTGGCAGAAG
CTCTGCAAAGCTGATGGTGTTCTTGTGCCAGGAGGCTTTGGAATCAGAGGAACGTTGGGA
AAACTCCAGGCAATTTCTTGGGCACGGTCAAGGAAGATTCCTTTTCTGGGAGTTTGCCTT
GGGATGCAGCTGGCAGTGATAGAGTTTGCACGAAACTGCCTTAACTTGAAAGATGCTGAT
TCCACAGAATTTGAGCCAAATGCCCGTGTTCCTGTGGTGATTGATATGCCGGAGCACAAC
CCTGGCAATTTGGGAGGAACGATGAGGCTGGGAATAAGAAGAACTGTTTTCAAAACTGAA
AATTCAATATTAAGGAAACTTTATGGTGATGTACCTTTCATAGAAGAAAGACACAGACAT
CGGTATGAGGTGAATCCTAGCCTCATCAGCCAACTTGAGCAGAAAGACTTAAGTTTTGTA
GGTCAGGATGTTGATGGAGAGAGGATGGAAATCATTGAACTGGCAAATCACCCCTATTTT
GTTGGTGTCCAGTTCCATCCCGAGTTTTCTTCTAGGCCAATGAAGCCTTCCCCTCCATAC
CTGGGGCTGTTACTTGCGGCAACTGGGAATCTGAATGCCTATCTCCTACAGGGATGCAAG
CTGTCTTCAAGTGACAGATACAGTGATGCCAGTGATGACAGCTTTTCAGAGCCAAGGTTA
GCTGAGTTGGAAATCAGCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 586 |
| Molecular Weight
| 65481.0 |
| Theoretical pI
| 6.46 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>CTP synthase 2
MKYILVTGGVISGIGKGIIASSIGTILKSCGLRVTAIKIDPYINIDAGTFSPYEHGEVFV
LNDGGEVDLDLGNYERFLDINLYKDNNITTGKIYQHVINKERRGDYLGKTVQVVPHITDA
VQEWVMNQAMVPVDGHKEEPQICVIELGGTIGDIEGMPFVEAFRQFQFKAKRENFCNIHV
SLVPQPSATGEQKTKPTQNSVRALRGLGLSPDLIVCRSSTPIEMAVKEKISMFCHVNPEQ
VICIHDVSSTYRVPVLLEEQGIIKYFKERLDLPIGDSASSLLSKWRNMADRYERLQKTCS
IALVGKYTKLRDCYASVFKALEHSALAINHKLNLMYIDSIDLEQTTEVEDPVKFHEAWQK
LCKADGVLVPGGFGIRGTLGKLQAISWARSRKIPFLGVCLGMQLAVIEFARNCLNLKDAD
STEFEPNARVPVVIDMPEHNPGNLGGTMRLGIRRTVFKTENSILRKLYGDVPFIEERHRH
RYEVNPSLISQLEQKDLSFVGQDVDGERMEIIELANHPYFVGVQFHPEFSSRPMKPSPPY
LGLLLAATGNLNAYLLQGCKLSSSDRYSDASDDSFSEPRLAELEIS
|
| External Links |
|---|
| GenBank ID Protein
| ABQ12969.1 |
| UniProtKB/Swiss-Prot ID
| Q1RMS2 |
| UniProtKB/Swiss-Prot Entry Name
| PYRG2_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT030529 |
| GeneCard ID
| CTPS2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
