<?xml version="1.0" encoding="UTF-8"?>
<protein>
  <version>1.0</version>
  <creation_date>2018-05-07 22:25:39 UTC</creation_date>
  <update_date>2020-05-20 21:06:56 UTC</update_date>
  <accession>BMDBP01148</accession>
  <secondary_accessions>
  </secondary_accessions>
  <protein_type>Enzyme</protein_type>
  <synonyms>
  </synonyms>
  <gene_name>AK4</gene_name>
  <general_function>Nucleotide transport and metabolism</general_function>
  <specific_function>Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates (By similarity). Efficiently phosphorylates AMP and dAMP using ATP as phosphate donor, but phosphorylates only AMP when using GTP as phosphate donor (By similarity). Also displays broad nucleoside diphosphate kinase activity (By similarity). Plays a role in controlling cellular ATP levels by regulating phosphorylation and activation of the energy sensor protein kinase AMPK (By similarity). Plays a protective role in the cellular response to oxidative stress (By similarity).</specific_function>
  <pathways>
  </pathways>
  <metabolite_associations>
    <metabolite>
      <accession>BMDB0001341</accession>
      <name>ADP</name>
    </metabolite>
  </metabolite_associations>
  <go_classifications>
  </go_classifications>
  <subcellular_locations>
  </subcellular_locations>
  <gene_properties>
    <chromosome_location>3</chromosome_location>
    <locus/>
    <gene_sequence>&gt;672 bp
ATGGCTTCCAAACTCCTGCGTGCGGTCATCCTTGGGCCGCCGGGCTCGGGCAAGGGCACC
GTGTGCCAGAGGATAGCCCAGAACTTTGGCCTTCAGCATCTCTCCAGCGGCCACTTCTTG
CGGGAGAACATCAAGGCCAACACGGAAGTTGGTGATATGGCAAAGCAATACATAGAGAAA
GGCCTTTTGGTTCCCGATCATGTGATCACACGCCTCATGCTGTTGGAGTTGGAGAACAGG
CGCGGCGAGCACTGGCTACTTGACGGTTTTCCTCGAACATTAGTTCAGGCTGAAGCCTTG
GACAGACTATGTGACCTGGATCTAGTGATCACTTTGAACATTCCATTCGAAACGCTCAAA
GATCGTCTCAGCCGACGTTGGATTCATCCTCCCAGTGGAAGGGTATATAACCTGGACTTC
AACCCACCTCATGTACATGGCATGGATGACGTCACTGGTGAGCCACTGGTCCAGCAGGAG
GATGACAAACCTGAAGCAGTTGCTGCCAGACTAAGGCAGTACAAGGATGTGGCAAAACCC
GTCATCGAGTTGTACAAGAGCCGAGGAGTGCTCCACCAGTTTTCAGGAACCGAGACTAAC
AAAATCTGGCCCTATGTTTACACGCTTTTCTCGAACAAGATCACACCTGTTCAGTCCAAA
GAAGCCTACTGA</gene_sequence>
  </gene_properties>
  <protein_properties>
    <residue_number>223</residue_number>
    <molecular_weight>25348.0</molecular_weight>
    <theoretical_pi>8.24</theoretical_pi>
    <pfams>
    </pfams>
    <transmembrane_regions>
    </transmembrane_regions>
    <signal_regions>
      <region>None</region>
    </signal_regions>
    <polypeptide_sequence>&gt;Adenylate kinase isoenzyme 4, mitochondrial
MASKLLRAVILGPPGSGKGTVCQRIAQNFGLQHLSSGHFLRENIKANTEVGDMAKQYIEK
GLLVPDHVITRLMLLELENRRGEHWLLDGFPRTLVQAEALDRLCDLDLVITLNIPFETLK
DRLSRRWIHPPSGRVYNLDFNPPHVHGMDDVTGEPLVQQEDDKPEAVAARLRQYKDVAKP
VIELYKSRGVLHQFSGTETNKIWPYVYTLFSNKITPVQSKEAY</polypeptide_sequence>
  </protein_properties>
  <genbank_protein_id>AAI20078.1</genbank_protein_id>
  <uniprot_id>Q0VCP1</uniprot_id>
  <uniprot_name>KAD4_BOVIN</uniprot_name>
  <pdb_ids>
  </pdb_ids>
  <genbank_gene_id>BC120077</genbank_gene_id>
  <genecard_id>AK4</genecard_id>
  <geneatlas_id/>
  <general_references>
  </general_references>
  <metabolite_references>
  </metabolite_references>
</protein>
