| Identification |
|---|
| BMDB Protein ID
| BMDBP01147 |
| Secondary Accession Numbers
| None |
| Name
| Inhibitor of nuclear factor kappa-B kinase subunit beta |
| Synonyms
|
Not Available
|
| Gene Name
| IKBKB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Serine kinase that plays an essential role in the NF-kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since they exert a negative regulation on canonical IKKs. Phosphorylates FOXO3, mediating the TNF-dependent inactivation of this pro-apoptotic transcription factor. Also phosphorylates other substrates including NCOA3, BCL10 and IRS1. Within the nucleus, acts as an adapter protein for NFKBIA degradation in UV-induced NF-kappa-B activation (By similarity). Phosphorylates RIPK1 at 'Ser-25' which represses its kinase activity and consequently prevents TNF-mediated RIPK1-dependent cell death (By similarity). |
| Pathways
|
- CD40L Signalling Pathway
- Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
- Intracellular Signalling Through Adenosine Receptor A2b and Adenosine
- LPS and Citrate Signaling and Inflammation
- NF-kB Signaling Pathway
- Succinate Signalling During Inflammation
- TNF/Stress Related Signaling
- Toll-Like Receptor Pathway 1
- Toll-Like Receptor Pathway 2
|
| Reactions
|
| NF-kappa-B inhibitor alpha → NF-kappa-B inhibitor alpha + Hydrogen phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 27 |
| Locus
| Not Available |
| SNPs
| IKBKB |
| Gene Sequence
|
>2271 bp
ATGAGCTGGTCACCTTCCCTGCCAACCCAGACATGTGGGGCCTGGGAAATGAAAGAGCGT
CTTGGGACAGGGGGATTTGGGAACGTCATCCGATGGCACAATCAGGAGACGGGCGAGCAG
ATCGCCATCAAGCAGTGCCGGCAAGAGCTCAGTCCCCGGAACCGCGAGCGCTGGTGCCTG
GAGATCCAGATCATGAGGAGGCTGAACCACCCCAATGTGGTGGCCGCCCGGGACGTCCCT
GAAGGCATGCAGAGCCTGGCTCCCAACGACCTGCCCCTGCTGGCCATGGAGTACTGCCAG
GGCGGGGACCTGCGCAAGTACCTGAACCAGTTTGAGAACTGCTGCGGCCTGCGGGAAGGA
GCCATCCTCACCTTGCTGAGCGACATTGCCTCTGCACTTCGATACCTTCATGAGAACAGA
ATCATCCATCGGGATCTGAAGCCAGAAAACATTGTCCTGCAGCAAGGGGAACAGAGATTA
ATACACAAAATTATTGACCTGGGATACGCCAAGGAGCTGGACCAGGGCAGCCTCTGCACG
TCCTTCGTGGGGACCCTGCAGTACCTGGCCCCCGAGCTGCTGGAGCAGCAGAAGTACACG
GTGACCGTGGACTACTGGAGCTTCGGCACCTTGGCCTTCGAGTGCATCACCGGCTTCCGG
CCTTTCCTGCCCAACTGGCAGCCCGTGCAGTGGCACTCCAAAGTCCGGCAGAAGAGCGAG
ATGGACATTGTGGTGAGCGAGGACCTGAACGGGGCCGTGAAGTTCTCCAGCTCGCTGCCG
CACCCCAACAACCTCAACAGCGTCCTGGCCCAGCGGCTGGAGAAGTGGCTGCAGCTGATG
CTGATGTGGCACCCGCGCCAGAGGGGCACCGACCCTGTCTACGGGCCCAACGGCTGCTTC
AAGGCCCTGGACGACATCTTGAACTTGAAGCTGCTTCATGTCCTGAACATGGTCACGGGC
ACCCTGCACACCTACCCCGTGACCGAGGACGAGAGCCTGCAGAGCCTGAAGGCCCGCATC
CGCCAGGACACAGGCATCCTCGAGGAGGACCAGGAGCTGCTGCAGGAGGCAGGGCTGGCC
CTGATCCCCGACAAGCCTGCCGCCCAGTGCCTCTCGGACGGCAAGCTGAACGAGGGCCGC
ACGCTGGACATGGACCTCGTTTTCCTCTTTGACAACAGCAGGGTCACCTATGAAAGCCAG
GTCTCCCCACAGCCCCAGCCTGAAAGCGTCAGCTGCATCTTGCAAGAGCCCAAGAGGAAC
CTCCCGTTCTTCCAGCTGCGGAAGGTGTGGGGCCAAGTCTGGCACAGCATCCAGGCCCTG
AAGGAAGACTGCAGCCGCCTGCAGCAGGGCCAGCGCGCGGCCATGATGAATCTGCTGCGG
AACAACAGCTGTCTGTCCAAGATGAAGAACTCCATGGCCTCCATGTCTCAGCAGCTCAAG
GCCAAGCTGGACTTCTTTAAGACTAGTATCCAGATTGACCTGGAGAAGTACAGGGAGCAG
ACGGAGTTTGGGATCACGTCGGACAAGCTGCTGCTAGCCTGGAGGGAGATGGAGCAGGCC
GTGGAGCTCTGCGGACGGGAGAACGAGGTGAAGCACTTGGTGGAGCGGATGATGGCCCTG
CAGACGGACATCGTGGACCTGCAGCGCAGCCCCATGGGCCGGAAGCAGGGCGGGACGCTG
GATGATCTGGAAGAGCAGGCGCGGGAGCTTTACCGCAGGCTGAGGGAGAAGCCCAGAGAC
CAGCGGACTGATGGTGACAGTCAGGAAATGGTGCGGCTGCTCCTCCAGGCAATCCAAGGC
TTTGAGAAGAAAGTGCGAGTGATTTATACGCAGCTCAGTAAGACCGTGGTCTGCAAGCAG
AAGGCCCTGGAACTGCTGCCCAAGGTGGAGGAGGTGGTCAGCCTGATGAGCGAGGACGAG
AAGATGGTGGTGCGGCTGCAGGAGAAGCGGCAGAAGGAGCTCTGGAACCTCCTGAAGATT
GCGTGTAGCAAGGTCCGGGGTCCCGTCAGCGGAAGCCCGGACAGTATGAACGCCTCCCGC
CTGAGTCACCCCTGCCAGCTGATGTCACAGCCCTGCACGGCTCCCGACAGCTTGCCCGAG
GCCGCCGAGAAGAGTGAGGACCTGGTGGCTGAAGCTCACACCCTGTGCACCCAGCTGGAG
AACGCCCTGCAGGACACCATGAAGGAGCAGGACCAGAGTTTGAGGTCTCTAGACTGGAGC
TGGTTGCAGTCGGAGGAGGAGGAACAGCAGAGCCTGGAGCGGGCCTCGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 756 |
| Molecular Weight
| 86647.0 |
| Theoretical pI
| 5.85 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inhibitor of nuclear factor kappa-B kinase subunit beta
MSWSPSLPTQTCGAWEMKERLGTGGFGNVIRWHNQETGEQIAIKQCRQELSPRNRERWCL
EIQIMRRLNHPNVVAARDVPEGMQSLAPNDLPLLAMEYCQGGDLRKYLNQFENCCGLREG
AILTLLSDIASALRYLHENRIIHRDLKPENIVLQQGEQRLIHKIIDLGYAKELDQGSLCT
SFVGTLQYLAPELLEQQKYTVTVDYWSFGTLAFECITGFRPFLPNWQPVQWHSKVRQKSE
MDIVVSEDLNGAVKFSSSLPHPNNLNSVLAQRLEKWLQLMLMWHPRQRGTDPVYGPNGCF
KALDDILNLKLLHVLNMVTGTLHTYPVTEDESLQSLKARIRQDTGILEEDQELLQEAGLA
LIPDKPAAQCLSDGKLNEGRTLDMDLVFLFDNSRVTYESQVSPQPQPESVSCILQEPKRN
LPFFQLRKVWGQVWHSIQALKEDCSRLQQGQRAAMMNLLRNNSCLSKMKNSMASMSQQLK
AKLDFFKTSIQIDLEKYREQTEFGITSDKLLLAWREMEQAVELCGRENEVKHLVERMMAL
QTDIVDLQRSPMGRKQGGTLDDLEEQARELYRRLREKPRDQRTDGDSQEMVRLLLQAIQG
FEKKVRVIYTQLSKTVVCKQKALELLPKVEEVVSLMSEDEKMVVRLQEKRQKELWNLLKI
ACSKVRGPVSGSPDSMNASRLSHPCQLMSQPCTAPDSLPEAAEKSEDLVAEAHTLCTQLE
NALQDTMKEQDQSLRSLDWSWLQSEEEEQQSLERAS
|
| External Links |
|---|
| GenBank ID Protein
| CAC93687.1 |
| UniProtKB/Swiss-Prot ID
| Q95KV0 |
| UniProtKB/Swiss-Prot Entry Name
| IKKB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AJ414556 |
| GeneCard ID
| IKBKB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
