1.0 2018-05-07 22:25:37 UTC 2020-05-20 21:01:38 UTC BMDBP01143 Enzyme MAPK7 Involved in ATP binding Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression (By similarity). Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction (By similarity). GnRH Signaling Pathway SMP0120925 BMDB0000547 Magnesium BMDB0001341 ADP 19 >2346 bp ATGGCTGAGCCCCTGAAGGAGGACGACGGTGAGGACGGCTCCGGGGAGCCCCCCGGGCCG GTGAAGGCGGAACCCGCTGGCACCGCCGCCTCGGTGGCTGCCAAGAACTTGGCCCTGCTG AAGGCGCGGTCCTTCGACGTGACCTTCGACGTGGGGGACGAGTACGAGATCATCGAGACC ATTGGCAACGGGGCCTACGGGGTGGTGTCCTCCGCGCGCCGCCGCCTCACCGGCCAGCAG GTGGCCATTAAGAAGATCCCTAATGCTTTTGACGTGGTGACCAATGCCAAGCGGACCCTC AGAGAGCTGAAGATCCTCAAGCACTTCAAGCACGACAACATCATTGCCATAAAGGACATC CTGAGGCCCACTGTACCCTATGGCGAGTTCAAATCTGTCTACGTGGTCCTGGACCTGATG GAGAGCGACCTGCACCAGATCATCCACTCCTCACAGCCGCTGACACTGGAGCATGTGCGC TACTTCCTGTACCAGCTGCTGCGGGGCCTCAAGTACATGCACTCGGCTCAGGTCATCCAC CGCGACCTCAAGCCCTCCAACCTACTGGTGAACGAGAACTGCGAGCTCAAGATTGGGGAC TTTGGCATGGCCCGTGGCCTGTGCACCTCGCCCGCTGAGCACCAGTACTTCATGACCGAG TATGTGGCCACTCGCTGGTACCGCGCCCCTGAGCTCATGCTCTCGCTGCACGAGTACACG CAGGCCATCGACCTGTGGTCCGTGGGCTGCATCTTTGGGGAGATGCTGGCCCGGCGCCAA CTCTTCCCAGGCAAAAACTATGTGCACCAGCTGCAGCTGATCATGACGGTGCTAGGTACC CCGTCGCCGGCCGTGATTCAGGCTGTGGGAGCTGAGAGGGTGCGGGCCTATATCCAGAGC CTGCCACCACGCCAGCCTGTGCCCTGGGAGACGGTGTACCCGGGCGCCGACCGCCAGGCG CTCTCCCTACTGGGGCGCATGCTACGTTTTGAGCCCAGCGCCCGTGTCTCTGCAGCTGCT GCCCTCCGCCACCCCTTCCTGGCCAAGTACCATGACCCCGACGACGAGCCTGACTGTGCC CCGCCCTTTGACTTTGCCTTTGACCGTGAAGCCCTCACACGGGAGCGCATTAAGGAGGCC ATTGTGGCGGAGATCGAGGACTTCCATGCACGGCGCGAGGGCATCCGCCAGCAGATCCGC TTCCAGCCTTCCTTGCAGCCTGTGGCCAGTGAGCCTGGCTGCCCCGATGTGGAAATGCCC AGCCCCTGGGCTCCGAGTGGGGACTGCGCCATGGAGTCCCCTCCGCCAGCCCCACTGCCA TGCCCTGGCCCTGCGCCCGACACCATCGATCTGACCCTGCAGCCGCCCCCACCAGCCAGT GAACCAGCCCCTCCAAAGAAGGAGGGGGCCATCTCAGACAACACCAAGGCTGCCCTCAAG GCTGCCTTGCTCAAGTCCTTGCGGAGCCGGCTCCGAGATGGCCCCAGTGCCCCCCTGGAA GCTCCTGAGCCTCGGAAGCCGGTGACTGCTCAGGAGCGCCAGCGGGAGCGGGAGGAGAAA CGCCGACGGCGGCAGGAGCGGGCCAAGGAGCGAGAGAAGAGGCGGCAGGAGCGGGAGCGC AAGGAGCGGGGCGCGGGGGTCTCGGGGGGCCCCTCCGCTGACCCCCTGGCTGGGCTGGTG CTTAGCGACAACGACCGCAGCCTGCTGGAGCGTTGGACTCGCATGGCCCAGCCCCCCGCC CCCGCACCCGCCACAGCCCGGCCCCCCAGCCCTCCCGCTGGCCCTGCCACCCAGCCCACT GGGCCCCTGCCACAGCCGGCCTGCCCACCCCCTGCACCTGCAGCTGGCCCTGCTGCTCCC CAGACCACCGCCGCCTCCGGCCTCCTGGCCCCCCAGCCGCTGGTGCCGCCCCCTGGGCTG CCCGGCCCCAGTGCCCTGAGTGTTCTCCCTTACTTCCCCTCTGGCCCACCCCCTCCAGAC CCCGGGGGGGCCCCACAGCCCTCCACATCGGAGTCACCTGACGTCACCCTGGTGACCCAG CAGCTGTCCAAGTCACAGGTGGAGGACCCTTTGCCCCCCGTGTTCTCGGGCACCCCCAAG GGCAGTGGAGCTGGGTATGGTGTTGGCTTTGACCTGGAGGAATTCCTAAACCAGTCTTTT GACATGGGTGTGGCTGATGGGCCACAAGACGGCCAGGCAGACTCAGCCTCGCTCTCAGCC TCCCTGCTCGCTGACTGGCTCGAGGGCCACGGCATGAACCCTGCTGACATCGAGTCCCTG CAGCGTGAGATCCAGATGGATTCCCCCATGCTGCTGGCCGACCTGCCCGACCTCCAAGAG CCCTGA 781 84832.0 5.49 None >Mitogen-activated protein kinase 7 MAEPLKEDDGEDGSGEPPGPVKAEPAGTAASVAAKNLALLKARSFDVTFDVGDEYEIIET IGNGAYGVVSSARRRLTGQQVAIKKIPNAFDVVTNAKRTLRELKILKHFKHDNIIAIKDI LRPTVPYGEFKSVYVVLDLMESDLHQIIHSSQPLTLEHVRYFLYQLLRGLKYMHSAQVIH RDLKPSNLLVNENCELKIGDFGMARGLCTSPAEHQYFMTEYVATRWYRAPELMLSLHEYT QAIDLWSVGCIFGEMLARRQLFPGKNYVHQLQLIMTVLGTPSPAVIQAVGAERVRAYIQS LPPRQPVPWETVYPGADRQALSLLGRMLRFEPSARVSAAAALRHPFLAKYHDPDDEPDCA PPFDFAFDREALTRERIKEAIVAEIEDFHARREGIRQQIRFQPSLQPVASEPGCPDVEMP SPWAPSGDCAMESPPPAPLPCPGPAPDTIDLTLQPPPPASEPAPPKKEGAISDNTKAALK AALLKSLRSRLRDGPSAPLEAPEPRKPVTAQERQREREEKRRRRQERAKEREKRRQERER KERGAGVSGGPSADPLAGLVLSDNDRSLLERWTRMAQPPAPAPATARPPSPPAGPATQPT GPLPQPACPPPAPAAGPAAPQTTAASGLLAPQPLVPPPGLPGPSALSVLPYFPSGPPPPD PGGAPQPSTSESPDVTLVTQQLSKSQVEDPLPPVFSGTPKGSGAGYGVGFDLEEFLNQSF DMGVADGPQDGQADSASLSASLLADWLEGHGMNPADIESLQREIQMDSPMLLADLPDLQE P AAI42511.1 A5PKJ4 MK07_BOVIN BC142510 MAPK7