| Identification |
|---|
| BMDB Protein ID
| BMDBP01026 |
| Secondary Accession Numbers
| None |
| Name
| Inositol-3-phosphate synthase 1 |
| Synonyms
|
Not Available
|
| Gene Name
| ISYNA1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner. Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). |
| Pathways
|
- Inositol Metabolism
- Inositol Phosphate Metabolism
- Myo-inositol biosynthesis
- Myo-inositol from D-glucose 6-phosphate: step 1/2
- Polyol metabolism
|
| Reactions
|
| Glucose 6-phosphate → Myo-inositol 1-phosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| ISYNA1 |
| Gene Sequence
|
>1674 bp
ATGGAGGCCGCAACTGAGTTCGTGGTCGAGAGCCCCGACGTTGTCTACAGCCCCGAGACC
ATCGAGGCGCAGTACGAGTACCGGACGACGAGCGTCAGCCGCGAGGGCGGCGTCCTCAAG
GTGCACCCCACGTCCACGCGCTTCACTTTCCGGACCGCCCGGCAGGTGCCCCGGCTCGGG
GTCATGCTCGTCGGCTGGGGCGGCAACAACGGCTCCACACTGACCGCTGCCGTGCTGGCT
AACCGACTGCGCTTGTCCTGGCCCACGCGCACGGGCCGCAAGGAGGCCAACTACTACGGC
TCACTGACGCAGGCAGGCACTGTTAGCCTGGGCCTGGACGCCGAGGGCAAGGAAGTGTTC
GTGCCCTTCAGTTCACTGCTGCCCATGGTGGCGCCCGACGACCTCGTGTTCGACGGCTGG
GACATATCTTCGCTGAACCTGGCGGAGGCGATGCGGCGTGCACAGGTACTGGACTGGGGA
CTGCAGGAGCAACTCTGGCCGCACATGGAGGCCATGCGCCCGCGGCCCTCCGTCTACATC
CCGGAGTTCATCGCAGCTAACCAGAGTGCGCGCGCCGACAACGTCATCCCGGGCACGCGC
GCGCAGCAGCTGGAGCAGATCCGTAGGGACATCCGCGACTTTCGGTTCAGCGCCGGCCTG
GACAAAGTCATCGTGCTGTGGACAGCGAACACGGAGCGCTTCTGCGAAGTGATTCCAGGC
CTCAATGACACTGCTGAGAACCTGCTGCGCACCATCCAGCTGGGCCTGGAAGTGTCGCCC
TCCACACTCTTTGCCGTGGCCAGCATCTTGGAGGGCTGTGCCTTCCTCAATGGGTCCCCA
CAGAACACGCTGGTACCCGGTGCCCTCGAGCTCGCGTGGCAGCGCCGCGTTTTTGTGGGT
GGAGACGACTTCAAGTCGGGCCAGACCAAGGTCAAATCTGTGCTCGTGGACTTCCTTATC
GGCTCTGGCCTCAAGACCATGTCCATCGTGAGCTACAACCACCTGGGCAACAACGACGGG
CAGAACTTGTCAGCGCCCCCACAGTTTCGCTCCAAGGAGGTGTCCAAGAGCAGCGTGGTG
GACGACATGGTGCACAGCAACCCGGTGCTCTACTCGCCGGGCGAACAGCCCGACCACTGC
GTGGTCATCAAGTACGTGCCATACGTGGGCGACAGCAAGCGTGCCCTGGATGAGTACACA
TCGGAGCTGATGCTGGGTGGTACCAACACGTTGGTGCTGCACAACACGTGCGAGGACTCG
CTCCTGGCCGCACCCATCATGCTGGACCTGGCCCTGCTGACTGAACTATGTCAGCGAGTG
AGCTTCTGCACCGACGTCGACCCGGACCCGCAGAGCTTCCATCCGGTGCTGTCACTGCTC
GGCTTCCTCTTCAAGGCGCCACTTGCACCACCCGGCAGCCCCGTAGTCAATGCGCTCTTC
CGCCAGCGCAGCTGCATCGAGAATATCCTCAGGGCCTGCGTGGGGCTCCCGCCGCAGAAC
CACATGCTTCTGGAGCACAAGATGGAACGCCCTGGCCTCAAGAGAGTTGGGCCCTTGGCC
ACCACCTCTCCGGTGCTTTGCAAGAAAGGATCTGCGCCGACCGCACCCAATGGCTGTACT
GGTGATGCCAATGGGCACTCACAGGCTGAGGCACCCCAGATGCCCACCACCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 557 |
| Molecular Weight
| 60761.0 |
| Theoretical pI
| 5.85 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inositol-3-phosphate synthase 1
MEAATEFVVESPDVVYSPETIEAQYEYRTTSVSREGGVLKVHPTSTRFTFRTARQVPRLG
VMLVGWGGNNGSTLTAAVLANRLRLSWPTRTGRKEANYYGSLTQAGTVSLGLDAEGKEVF
VPFSSLLPMVAPDDLVFDGWDISSLNLAEAMRRAQVLDWGLQEQLWPHMEAMRPRPSVYI
PEFIAANQSARADNVIPGTRAQQLEQIRRDIRDFRFSAGLDKVIVLWTANTERFCEVIPG
LNDTAENLLRTIQLGLEVSPSTLFAVASILEGCAFLNGSPQNTLVPGALELAWQRRVFVG
GDDFKSGQTKVKSVLVDFLIGSGLKTMSIVSYNHLGNNDGQNLSAPPQFRSKEVSKSSVV
DDMVHSNPVLYSPGEQPDHCVVIKYVPYVGDSKRALDEYTSELMLGGTNTLVLHNTCEDS
LLAAPIMLDLALLTELCQRVSFCTDVDPDPQSFHPVLSLLGFLFKAPLAPPGSPVVNALF
RQRSCIENILRACVGLPPQNHMLLEHKMERPGLKRVGPLATTSPVLCKKGSAPTAPNGCT
GDANGHSQAEAPQMPTT
|
| External Links |
|---|
| GenBank ID Protein
| AAI11161.1 |
| UniProtKB/Swiss-Prot ID
| Q2NL29 |
| UniProtKB/Swiss-Prot Entry Name
| INO1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC111160 |
| GeneCard ID
| ISYNA1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
