| Identification |
|---|
| BMDB Protein ID
| BMDBP00982 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin-conjugating enzyme E2 D1 |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2D1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| UBE2D1 |
| Gene Sequence
|
>444 bp
ATGGCGCTGAAGCGGATTCAGAAAGAGTTAAGTGATCTACAACGTGACCCACCTGCTCAC
TGTTCGGCTGGACCTGTGGGAGATGACTTGTTCCACTGGCAAGCAACTATTATGGGGCCT
CCTGATAGCGCATATCAAGGTGGAGTCTTCTTTCTCACTGTACATTTTCCGACAGACTAT
CCTTTTAAACCACCAAAGATTGCTTTCACAACAAAAATTTACCATCCAAACATAAACAGT
AATGGAAGTATTTGTCTTGATATCCTGAGGTCACAATGGTCACCAGCTCTGACTGTGTCA
AAAGTTTTATTGTCCATATGTTCTCTGCTTTGTGACCCTAATCCAGATGATCCCTTAGTA
CCAGATATTGCTCAAATCTATAAATCAGACAAAGAAAAATACAACAGACACGCAAGAGAA
TGGACTCAGAAATATGCAATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 147 |
| Molecular Weight
| 16602.0 |
| Theoretical pI
| 7.5 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 D1
MALKRIQKELSDLQRDPPAHCSAGPVGDDLFHWQATIMGPPDSAYQGGVFFLTVHFPTDY
PFKPPKIAFTTKIYHPNINSNGSICLDILRSQWSPALTVSKVLLSICSLLCDPNPDDPLV
PDIAQIYKSDKEKYNRHAREWTQKYAM
|
| External Links |
|---|
| GenBank ID Protein
| AAI11176.1 |
| UniProtKB/Swiss-Prot ID
| Q2TA10 |
| UniProtKB/Swiss-Prot Entry Name
| UB2D1_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC111175 |
| GeneCard ID
| UBE2D1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
