| Identification |
|---|
| BMDB Protein ID
| BMDBP00978 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin-conjugating enzyme E2 D2 |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2D2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. |
| Pathways
|
- P53 Signaling Pathway
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| UBE2D2 |
| Gene Sequence
|
>444 bp
ATGGCTCTGAAGAGAATCCATAAGGAATTGAATGACCTGGCACGGGACCCCCCAGCACAG
TGTTCAGCAGGTCCCGTTGGAGATGATATGTTCCATTGGCAAGCTACAATAATGGGGCCA
AATGACAGTCCCTATCAGGGTGGAGTATTTTTCTTGACAATTCATTTCCCAACAGATTAC
CCCTTCAAACCACCTAAGGTTGCATTTACAACAAGAATTTATCATCCAAATATTAACAGT
AATGGCAGCATTTGTCTTGATATTCTACGGTCACAGTGGTCTCCAGCACTAACTATTTCA
AAAGTACTTTTGTCCATCTGTTCTCTGTTGTGTGATCCCAATCCAGATGATCCTTTAGTG
CCTGAGATTGCTCGGATCTACAAAACAGATAGAGAAAAGTACAACAGAATAGCTCGGGAA
TGGACTCAGAAGTATGCGATGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 147 |
| Molecular Weight
| 16735.0 |
| Theoretical pI
| 7.96 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 D2
MALKRIHKELNDLARDPPAQCSAGPVGDDMFHWQATIMGPNDSPYQGGVFFLTIHFPTDY
PFKPPKVAFTTRIYHPNINSNGSICLDILRSQWSPALTISKVLLSICSLLCDPNPDDPLV
PEIARIYKTDREKYNRIAREWTQKYAM
|
| External Links |
|---|
| GenBank ID Protein
| AAI14655.1 |
| UniProtKB/Swiss-Prot ID
| Q1RMX2 |
| UniProtKB/Swiss-Prot Entry Name
| UB2D2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC114654 |
| GeneCard ID
| UBE2D2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
