| Identification |
|---|
| BMDB Protein ID
| BMDBP00975 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin-conjugating enzyme E2 C |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2C |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| UBE2C |
| Gene Sequence
|
>540 bp
ATGGCTTCCCAGAACCGCGACCCAGTCGCCGCCAGCGTCGCCGCCGCCCGTAAAGGAGCC
GAGCCCAGCGGGGGTGCTGCCCGGGGCCCTGTGGGCAAGAGGCTACAACAGGAGCTGATG
ACTCTCATGATGTCTGGCGATAAAGGAATTTCTGCCTTCCCTGAATCCGACAACCTCTTC
AAATGGGTGGGGACCATCCATGGAGCCGCTGGCACAGTATATGAAGACCTGAGGTATAAA
CTGTCCCTGGAGTTCCCCAGTGGCTACCCTTACAACGCGCCCACGGTGAAGTTCCTCACA
CCCTGCTACCATCCCAATGTGGACACCCAGGGTAACATCTGTCTGGACATCCTGAAAGAC
AAGTGGTCCGCCCTGTATGACGTCAGGACCATCCTGCTCTCCATCCAGAGTCTGCTCGGA
GAGCCCAACATTGATAGCCCTTTGAACACACATGCTGCCGAGCTCTGGAAAAACCCCACA
GCCTTTAAGAAGTACCTGCAAGAAACCTACTCAAAGCAGGTCTCCAGCCAAGACCCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 179 |
| Molecular Weight
| 19608.0 |
| Theoretical pI
| 7.5 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 C
MASQNRDPVAASVAAARKGAEPSGGAARGPVGKRLQQELMTLMMSGDKGISAFPESDNLF
KWVGTIHGAAGTVYEDLRYKLSLEFPSGYPYNAPTVKFLTPCYHPNVDTQGNICLDILKD
KWSALYDVRTILLSIQSLLGEPNIDSPLNTHAAELWKNPTAFKKYLQETYSKQVSSQDP
|
| External Links |
|---|
| GenBank ID Protein
| AAI08196.1 |
| UniProtKB/Swiss-Prot ID
| Q32PA5 |
| UniProtKB/Swiss-Prot Entry Name
| UBE2C_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC108195 |
| GeneCard ID
| UBE2C |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
