| Identification |
|---|
| BMDB Protein ID
| BMDBP00969 |
| Secondary Accession Numbers
| None |
| Name
| Ubiquitin-conjugating enzyme E2 L3 |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2L3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN and ARIH1, that function like function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis. |
| Pathways
|
- Protein modification
- Protein ubiquitination
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| Not Available |
| SNPs
| UBE2L3 |
| Gene Sequence
|
>465 bp
ATGGCGGCCAGCAGGAGGCTGATGAAGGAGCTTGAAGAAATCCGCAAGTGTGGGATGAAA
AACTTCCGTAACATCCAGGTCGATGAAGCTAATTTGCTGACTTGGCAAGGGCTCATTGTT
CCCGACAACCCTCCCTATGATAAGGGGGCCTTCAGAATCGAAATCAACTTTCCAGCAGAG
TACCCCTTCAAACCACCGAAGATCACGTTCAAAACGAAGATCTACCACCCGAACATCGAC
GAGAAGGGGCAGGTGTGTCTGCCTGTAATTAGTGCTGAAAACTGGAAGCCAGCAACCAAA
ACCGACCAAGTCATCCAGTCCCTCATAGCACTGGTGAACGACCCCCAGCCGGAGCACCCG
CTCCGGGCTGACCTAGCCGAAGAATACTCTAAGGACCGTAAAAAATTCTGTAAGAATGCT
GAAGAATTTACAAAGAAATATGGGGAAAAGCGACCTGTGGACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 154 |
| Molecular Weight
| 17862.0 |
| Theoretical pI
| 8.79 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Ubiquitin-conjugating enzyme E2 L3
MAASRRLMKELEEIRKCGMKNFRNIQVDEANLLTWQGLIVPDNPPYDKGAFRIEINFPAE
YPFKPPKITFKTKIYHPNIDEKGQVCLPVISAENWKPATKTDQVIQSLIALVNDPQPEHP
LRADLAEEYSKDRKKFCKNAEEFTKKYGEKRPVD
|
| External Links |
|---|
| GenBank ID Protein
| AAI05165.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHP1 |
| UniProtKB/Swiss-Prot Entry Name
| UB2L3_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC105164 |
| GeneCard ID
| UBE2L3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
