| Identification |
|---|
| BMDB Protein ID
| BMDBP00968 |
| Secondary Accession Numbers
| None |
| Name
| NEDD8-conjugating enzyme UBE2F |
| Synonyms
|
Not Available
|
| Gene Name
| UBE2F |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ATP binding |
| Specific Function
| Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5. |
| Pathways
|
- Protein modification
- Protein neddylation
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| UBE2F |
| Gene Sequence
|
>558 bp
ATGCTGACGCTGGCAAGCAAGCTGAAGCGGGATGATGGTCTCAAAGGGTCCCGGGCGTCA
GCCACAGCCTCTGACTCCACTCGGCGGGTGTCTGTGAGGGACAGGCTGCTTGTTAAAGAG
GTTGCAGAACTTGAAGCTAATTTACCTTGTACGTGTAAAGTGCATTTTCCTGATCCAAAC
AAGCTTCATTGCTTTCAGCTAACTGTCACCCCAGATGAGGGTTACTACCAGGGTGGAAAA
TTTCAGTTTGAAACTGAAGTTCCTGACGCATACAACATGGTGCCTCCCAAAGTGAAATGC
TTGACCAGGATCTGGCACCCCAACATCACCGAGACTGGTGAGATATGTCTCAGCTTACTG
AGAGAACACTCGATCGACGGCACCGGCTGGGCCCCCACAAGGACGCTGAAGGATGTTGTT
TGGGGATTAAACTCTTTGTTTACTGATCTGTTGAATTTTGATGATCCACTGAATATTGAA
GCTGCGGAACATCATTTGCGAGACAAGGAGGACTTCCGGAATAAAGTGGAGGACTACATT
AAGCGCTACGCCAGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 185 |
| Molecular Weight
| 21133.0 |
| Theoretical pI
| 6.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NEDD8-conjugating enzyme UBE2F
MLTLASKLKRDDGLKGSRASATASDSTRRVSVRDRLLVKEVAELEANLPCTCKVHFPDPN
KLHCFQLTVTPDEGYYQGGKFQFETEVPDAYNMVPPKVKCLTRIWHPNITETGEICLSLL
REHSIDGTGWAPTRTLKDVVWGLNSLFTDLLNFDDPLNIEAAEHHLRDKEDFRNKVEDYI
KRYAR
|
| External Links |
|---|
| GenBank ID Protein
| AAI14676.1 |
| UniProtKB/Swiss-Prot ID
| Q1RMW1 |
| UniProtKB/Swiss-Prot Entry Name
| UBE2F_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC114675 |
| GeneCard ID
| UBE2F |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
