| Identification |
|---|
| BMDB Protein ID
| BMDBP00961 |
| Secondary Accession Numbers
| |
| Name
| 3-hydroxyacyl-CoA dehydrogenase type-2 |
| Synonyms
|
Not Available
|
| Gene Name
| HSD17B10 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Mitochondrial dehydrogenase that catalyzes the beta-oxidation at position 17 of androgens and estrogens and has 3-alpha-hydroxysteroid dehydrogenase activity with androsterone. Catalyzes the third step in the beta-oxidation of fatty acids. Carries out oxidative conversions of 7-alpha-OH and 7-beta-OH bile acids. Also exhibits 20-beta-OH and 21-OH dehydrogenase activities with C21 steroids. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD). Essential for structural and functional integrity of mitochondria. |
| Pathways
|
Not Available
|
| Reactions
|
| 2-Methyl-3-hydroxybutyryl-CoA + NAD → 2-Methylacetoacetyl-CoA + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| HSD17B10 |
| Gene Sequence
|
>786 bp
ATGGCAGCTGCTTGTCGGAGCGTGAAGGGTCTGGTTGCCTTAATAACCGGCGGAGCCTCA
GGCCTAGGCTTGGCCACAGCGGAGCGACTGGTGGGGCAGGGGGCCACTGCTGTACTTTTG
GACCTGCCCAACTCAGATGGGGAGACCCAGGCCAAGAAGTTAGGGAAGAGCTGCGCCTTT
GCCCCAGCCGACGTGACCTCAGAGAAGGATGTGCAAGCAGCCCTGACTCTAGCAAGAGAA
AAGTTTGGCCGTGTGGATGTGGCAGTCAACTGTGCAGGCATTGCAGTGGCCAGCAAGACA
TATAACTTAAAGAAAAGCCAGGCCCATACCTTGGAGGACTTTCAGCGAGTTATCAATGTG
AATCTCATAGGCACCTTCAATGTGATCCGCCTGGTGGCTGGTGAGATGGGCCAGAACGAA
CCAGACCAGGGAGGCCAACGTGGGGTCATCATCAATACAGCCAGCGTAGCTGCCTTTGAG
GGCCAGGTTGGACAAGCTGCATACTCTGCTTCCAAGGGGGGCATAGTGGGCATGACATTG
CCCATTGCTCGGGATCTGGCTCCCATGGGTATCCGGGTGATGACCATTGCTCCAGGCCTA
TTTGGCACCCCGCTGTTGACCACCCTCCCAGATAAAGTGCGCAACTTCCTGGCCAGCCAG
GTGCCCTTCCCCAGCCGACTTGGTGACCCTGCCGAGTATGCTCATCTGGTACAGGCCATC
ATCGAGAACTCATTCCTCAATGGAGAAGTCATCCGGCTGGATGGGGCCATCCGCATGCAG
CCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 261 |
| Molecular Weight
| 27140.0 |
| Theoretical pI
| 8.48 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>3-hydroxyacyl-CoA dehydrogenase type-2
MAAACRSVKGLVALITGGASGLGLATAERLVGQGATAVLLDLPNSDGETQAKKLGKSCAF
APADVTSEKDVQAALTLAREKFGRVDVAVNCAGIAVASKTYNLKKSQAHTLEDFQRVINV
NLIGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTL
PIARDLAPMGIRVMTIAPGLFGTPLLTTLPDKVRNFLASQVPFPSRLGDPAEYAHLVQAI
IENSFLNGEVIRLDGAIRMQP
|
| External Links |
|---|
| GenBank ID Protein
| BAA19510.1 |
| UniProtKB/Swiss-Prot ID
| O02691 |
| UniProtKB/Swiss-Prot Entry Name
| HCD2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| AB002156 |
| GeneCard ID
| HSD17B10 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
