| Identification |
|---|
| BMDB Protein ID
| BMDBP00954 |
| Secondary Accession Numbers
| None |
| Name
| Alpha-aminoadipic semialdehyde dehydrogenase |
| Synonyms
|
Not Available
|
| Gene Name
| ALDH7A1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism (By similarity). |
| Pathways
|
- Amine and polyamine biosynthesis
- Betaine biosynthesis via choline pathway
- Betaine from betaine aldehyde: step 1/1
- Betaine Metabolism
- Lysine Degradation
|
| Reactions
|
| Betaine aldehyde + NAD + Water → Betaine + NADH |
details
|
| Allysine + NAD + Water → Aminoadipic acid + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| Not Available |
| SNPs
| ALDH7A1 |
| Gene Sequence
|
>1536 bp
ATGTCCACTCTGCTCATCAATCAACCCCAGTATGCTTGGCTGAAGGAGCTGGGGCTCCGC
GAGGAAAACGACGGCGTATATAATGGAAGCTGGGGAGGCCGGGGAGAGGTTATCACCACC
TACTGTCCTGCTAACAATGAGCCCATTGCAAGAGTCAGACAGGCCAGCATGGCTGACTAT
GAAGAAACTGTAGAGAAAGCACGAGAAGCATGGAGCATCTGGGCAGATGTTCCTGCTCCA
AAGCGAGGAGAAGTAGTGAGACAGATTGGTGATGCCTTGCGGGAGAAGATCCAAGTACTA
GGAAGCTTGGTGTCTTTGGAGATGGGGAAGATCTTGGTGGAAGGTGTGGGAGAAGTTCAG
GAATACGTGGATGTTTGTGATTATGCTGTTGGCTTATCTCGGATGATTGGGGGACCCATC
CTGCCTTCTGAAAGACCTGGCCATGCTCTCATTGAACAGTGGAATCCTGTAGGCCTGGTT
GGAATCATCACTGCTTTCAACTTCCCTGTGGCCGTGTATGGCTGGAACAACGCCATTGCC
ATGATCTGTGGGAATGCTTGTCTTTGGAAAGGAGCTCCTACAACTTCCCTCATCAGTGTA
GCTGTCACAAAAATAATAGCCAAAGTTCTGGAGGACAACAAGCTGCCTGGTGCAATTTGT
TCCTTGACTTGTGGTGGAGCAGATATCGGCACAGCAATGGCCAAGGATGAGCGAGTGGAC
CTGTTGTCCTTCACCGGGAGCACTCAAGTGGGAAAACAGGTGGCCCTTATGGTACAGGAG
AGGTTTGGGAGAAGTTTATTAGAACTTGGAGGAAACAATGCCATTATAGCTTTTGAGGAC
GCGGACCTCAGCTTAGTCGTCCCCTCAGCTCTCTTTGCAGCCGTGGGCACAGCCGGCCAG
AGGTGCACCACCGCGAGGCGCCTGTTCTTACATGAAAGCATCCATGATGAAGTTGTCAAT
AGACTTAAAAAGGCCTACGCACAGATCCGTGTTGGGAACCCTTGGGACTCTAATGTTCTG
TATGGGCCACTCCACACCAAACAGGCAGTGAGCATGTTTCTTGGAGCAGTGGAAGAAGCA
AAGAAAGAAGGTGGCACCGTTGTCTATGGTGGCAAGGTTATGGATCGCCCTGGAAATTAC
GTAGAACCGACAATCGTGACAGGTCTTGACCATGACGCATCCATTGTACACACAGAGACT
TTTGCCCCGATTCTTTATGTCTTTAAATTCAAGAATGAAGATGAGGTCTTTGCATGGAAC
AATGAAGTCAAACAGGGACTTTCAAGTAGCATCTTTACCAAGGATATGGGCAGAATCTTT
CGCTGGCTTGGACCAAAAGGATCAGACTGTGGCATTGTAAACGTCAACATTCCGACAAGT
GGGGCTGAGATTGGAGGTGCATTTGGAGGAGAGAAGCACACTGGCGGTGGCAGGGAGTCA
GGCAGTGATGCCTGGAAGCAGTACATGAGAAGATCTACTTGTACCATCAACTACAGTAAG
GACCTTCCTCTGGCCCAAGGAATCAAGTTTCAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 539 |
| Molecular Weight
| 58582.0 |
| Theoretical pI
| 5.75 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-aminoadipic semialdehyde dehydrogenase
MSTLLINQPQYAWLKELGLREENDGVYNGSWGGRGEVITTYCPANNEPIARVRQASMADY
EETVEKAREAWSIWADVPAPKRGEVVRQIGDALREKIQVLGSLVSLEMGKILVEGVGEVQ
EYVDVCDYAVGLSRMIGGPILPSERPGHALIEQWNPVGLVGIITAFNFPVAVYGWNNAIA
MICGNACLWKGAPTTSLISVAVTKIIAKVLEDNKLPGAICSLTCGGADIGTAMAKDERVD
LLSFTGSTQVGKQVALMVQERFGRSLLELGGNNAIIAFEDADLSLVVPSALFAAVGTAGQ
RCTTARRLFLHESIHDEVVNRLKKAYAQIRVGNPWDSNVLYGPLHTKQAVSMFLGAVEEA
KKEGGTVVYGGKVMDRPGNYVEPTIVTGLDHDASIVHTETFAPILYVFKFKNEDEVFAWN
NEVKQGLSSSIFTKDMGRIFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTGGGRES
GSDAWKQYMRRSTCTINYSKDLPLAQGIKFQ
|
| External Links |
|---|
| GenBank ID Protein
| AAI05407.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJC9 |
| UniProtKB/Swiss-Prot Entry Name
| AL7A1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105406 |
| GeneCard ID
| ALDH7A1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
