| Identification |
|---|
| BMDB Protein ID
| BMDBP00935 |
| Secondary Accession Numbers
| None |
| Name
| Adenylosuccinate lyase |
| Synonyms
|
Not Available
|
| Gene Name
| ADSL |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate. |
| Pathways
|
- 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate: step 2/2
- AMP biosynthesis via de novo pathway
- AMP from IMP: step 2/2.
- Aspartate Metabolism
- IMP biosynthesis via de novo pathway
- Purine Metabolism
|
| Reactions
|
| Adenylsuccinic acid → Fumaric acid + Adenosine monophosphate |
details
|
| SAICAR → Fumaric acid + AICAR |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| ADSL |
| Gene Sequence
|
>1473 bp
ATGGCCGCGGCGGGTGACCGTGGCGGGCGGGAGGCGGCCTGCGGGCATGACAGCTACCGT
TCGCCGCTTGCTTCCCGTTATGCTAGCCCGGAGATGTGCTTCCTGTTTAGCGACAAGTAC
AAATTCCGGACCTGGCGGCAGCTCTGGCTGTGGCTGGCGGAGGCCGAGCAGACACTGGGT
TTGCCTATCACAGATGAACAAATCCAGGAGATGAAATCAAACCTGGACAACATTGACTTC
AGGATGGCAGCTGAAGAGGAGAAGCAGTTGCGACATGATGTGATGGCCCACGTGCACACG
TTTGCCCACTGCTGCCCCAAAGCCGCCAGCATTATCCATCTTGGCGCCACCTCCTGCTAT
GTGGGAGACAATACGGACCTGATTATTCTCAGAAATGCATTTGACCTGCTTTTGCCAAAG
CTTGCCAGGGTGATCTCTCGGCTTGCCGACTTTGCCAAGGAACAAGCCGATCTCCCCACC
TTAGGTTTCACACATTTCCAGCCTGCTCAGCTGACCACAGTTGGGAAACGTTGCTGTCTC
TGGATTCAGGATCTGTGCATGGATCTCCAGAACCTGAAGCGTGTCCGGGATGAGCTGCGC
TTCCGAGGCGTGAAGGGTACCACTGGCACCCAGGCCAGCTTCCTGCAGCTCTTCGAAGGA
GATGACCAAAAGGTAGAACAGCTTGACAAGATGGTGACAGAAAAGGCAGGATTCAAGAGG
GCTTTTATCATCACAGGGCAGACCTATACACGAAAAGTAGATATTGAGGTGCTCTCTGTG
CTGGCTAGCTTGGGGGCATCGGTGCACAAGATTTGTACCGACATACGACTCCTGGCAAAC
CTCAAGGAGATGGAGGAGCCCTTTGAAAAACAGCAGATCGGCTCAAGTGCAATGCCATAC
AAGCGGAACCCTATGCGCTCAGAGCGGTGCTGCAGCCTGGCCCGGCACCTGATGGCCCTT
GTCATGGACCCCCTGCAGACGGCATCTGTGCAGTGGTTTGAACGCACACTCGATGACAGT
GCCAACCGACGTATCTGTTTGGCGGAGGCGTTTCTCACTGCAGATACTGTACTGAATACG
TTGCAGAACATTTCTGAAGGATTGGTGGTATACCCCAAAGTCATTGAGCGGCGCGTTCAG
CAGGAGCTGCCTTTCATGGCCACAGAGAACATCATCATGGCCATGGTGAAAGCCGGGGGT
AACCGCCAGGATTGCCGTGAGAAAATCAGAGTGCTCTCGCAGCAGGCAGCTGCCGTGGTC
AAGCAGGAAGGGGGTGACAATGACCTCATCGAGCGCATCCAGGCCGATGCCTACTTCAGT
CCAATCCACTCCCAGCTGGACCATTTGCTGGATCCTTCTTCTTTCACCGGCCGTGCGTCG
CAGCAGGTACAGAGATTCTTAGAAGAGGAGGTGTGTCCCCTGTTAAAACCGTATGAAAGT
GTGATGAAGGTGAAGGCAGAATTACGTCTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 490 |
| Molecular Weight
| 55484.0 |
| Theoretical pI
| 6.87 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Adenylosuccinate lyase
MAAAGDRGGREAACGHDSYRSPLASRYASPEMCFLFSDKYKFRTWRQLWLWLAEAEQTLG
LPITDEQIQEMKSNLDNIDFRMAAEEEKQLRHDVMAHVHTFAHCCPKAASIIHLGATSCY
VGDNTDLIILRNAFDLLLPKLARVISRLADFAKEQADLPTLGFTHFQPAQLTTVGKRCCL
WIQDLCMDLQNLKRVRDELRFRGVKGTTGTQASFLQLFEGDDQKVEQLDKMVTEKAGFKR
AFIITGQTYTRKVDIEVLSVLASLGASVHKICTDIRLLANLKEMEEPFEKQQIGSSAMPY
KRNPMRSERCCSLARHLMALVMDPLQTASVQWFERTLDDSANRRICLAEAFLTADTVLNT
LQNISEGLVVYPKVIERRVQQELPFMATENIIMAMVKAGGNRQDCREKIRVLSQQAAAVV
KQEGGDNDLIERIQADAYFSPIHSQLDHLLDPSSFTGRASQQVQRFLEEEVCPLLKPYES
VMKVKAELRL
|
| External Links |
|---|
| GenBank ID Protein
| AAI33475.1 |
| UniProtKB/Swiss-Prot ID
| A3KN12 |
| UniProtKB/Swiss-Prot Entry Name
| PUR8_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC133474 |
| GeneCard ID
| ADSL |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
