| Identification |
|---|
| BMDB Protein ID
| BMDBP00894 |
| Secondary Accession Numbers
| |
| Name
| Isobutyryl-CoA dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACAD8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Isobutyryl-CoA dehydrogenase which catalyzes one of the steps of the valine catabolic pathway. To a lesser extent, is also able to catalyze the oxidation of (2S)-2-methylbutanoyl-CoA. |
| Pathways
|
- Amino-acid degradation
- L-valine degradation
|
| Reactions
|
| Isobutyryl-CoA + electron-transfer flavoprotein → Methacrylyl-CoA + Reduced electron-transfer flavoprotein |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| ACAD8 |
| Gene Sequence
|
>1251 bp
ATGATGCTGCGAGGAGGCTGCCAGCGCGTCGGGGCGCGGCTGAGGGGGCTGCGCCGCGGG
CCCCGGGGCCCCGCCGACGGCGCCCGGCGGGGCGTGGTCTCCTGCATCGACCCTTCCATG
GGACTAAGTGAAGAGCAGAAAGAGTTCCAGAAAGTGGCCTTCAACTTTGCTGCCCGGGAG
ATGGCGCCGCACATGGCAGAGTGGGACCAGAAGGAGCTGTTCCCTGTGGACACGATGCGG
AAGGCAGCGCAGCTGGGCTTCGGGGGGGTGTATGTTCAAACAGATGTCGGAGGGGCGGGC
CTCTCGCGGCTGGACACCTCCATCATCTTTGAAGCCTTGGCCACAGGCTGCACCAGCACC
ACGGCCTACATGAGCATCCACAACATGTGTGTCTGGATTATCGACCGCTTCGGGAGCGAG
GAGCAGCGGCACCGGCTGTGCCCGCCCCTCTGCACCATGGAGAAGTTCGCCTCCTACTGC
CTCACAGAGCCAGGGAGTGGGAGCGACGCTGCCTCCCTCATGACCTCTGCCGTGCGACAA
CACGATCATTACATCCTCAATGGCTCCAAGGCCTTCATCAGTGGTGGCGGCGAAGCTGAC
ATCTATGTAGTCATGTGCCGCACAGGAGGGCCAGGCCCCAGAGGCATCTCCTGCGTAGTG
GTGGAGAAGGGGACCCCCGGCCTCAGCTTTGGCAAGAAGGAGAAAAAGGTGGGGTGGAAC
TCACAGCCGACCCAAGCAGTGATCTTTGAAGACTGTGCCGTCCCGGTGGCCAACAGGATC
GGGGACGAGGGCCAGGGCTTCCTCATCGCCATGAAGGGCCTGAATGGCGGGAGGATCAAT
GTTGCCTCCTGCTCCCTGGGCGCCGCTCACGCCTCGATCGTCCTCGCTCGAGACTACCTC
AAGGTCCGGAAGCAGTTTGGAGAGCCTCTGGCCAATAGCCAGTACCTGCAGTTTCAGCTG
GCCGACATGGCGGCCAGGCTGGTGGCCTCACGGCTGATGATCCGCACTGCGGCCACAGCT
CTGCAGGAGGAGCGAGAGGACGCGATAGTCCTGTGCTCCATGGCCAAACTCTTCGCTACG
GACGAATGCTTTGCGATCTGCAACCAGGCCCTACAAATGCATGGTGGCTATGGCTACCTG
AAAGACTATGCCGTCCAGCAGTATGTGCGGGACTCCCGGGTCCATCAGATCCTTGAAGGC
AGCAACGAAGTGATGCGGATGCTGATCTCGAGGAGCCTGCTGCAGGAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 416 |
| Molecular Weight
| 45307.0 |
| Theoretical pI
| 8.08 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Isobutyryl-CoA dehydrogenase, mitochondrial
MMLRGGCQRVGARLRGLRRGPRGPADGARRGVVSCIDPSMGLSEEQKEFQKVAFNFAARE
MAPHMAEWDQKELFPVDTMRKAAQLGFGGVYVQTDVGGAGLSRLDTSIIFEALATGCTST
TAYMSIHNMCVWIIDRFGSEEQRHRLCPPLCTMEKFASYCLTEPGSGSDAASLMTSAVRQ
HDHYILNGSKAFISGGGEADIYVVMCRTGGPGPRGISCVVVEKGTPGLSFGKKEKKVGWN
SQPTQAVIFEDCAVPVANRIGDEGQGFLIAMKGLNGGRINVASCSLGAAHASIVLARDYL
KVRKQFGEPLANSQYLQFQLADMAARLVASRLMIRTAATALQEEREDAIVLCSMAKLFAT
DECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQILEGSNEVMRMLISRSLLQE
|
| External Links |
|---|
| GenBank ID Protein
| ABD97096.1 |
| UniProtKB/Swiss-Prot ID
| Q0NXR6 |
| UniProtKB/Swiss-Prot Entry Name
| ACAD8_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| DQ435444 |
| GeneCard ID
| ACAD8 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
