| Identification |
|---|
| BMDB Protein ID
| BMDBP00888 |
| Secondary Accession Numbers
| None |
| Name
| Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| ACADSB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Has greatest activity toward short branched chain acyl-CoA derivative such as (s)-2-methylbutyryl-CoA, isobutyryl-CoA, and 2-methylhexanoyl-CoA as well as toward short straight chain acyl-CoAs such as butyryl-CoA and hexanoyl-CoA. Can use valproyl-CoA as substrate and may play a role in controlling the metabolic flux of valproic acid in the development of toxicity of this agent (By similarity). |
| Pathways
|
- Fatty Acid Metabolism
- Lipid metabolism
- Mitochondrial fatty acid beta-oxidation
- Valine, Leucine, and Isoleucine Degradation
|
| Reactions
|
| 2-Methylbutyryl-CoA + electron-transfer flavoprotein → Tiglyl-CoA + Reduced electron-transfer flavoprotein |
details
|
| Isobutyryl-CoA + electron-transfer flavoprotein → Methacrylyl-CoA + Reduced electron-transfer flavoprotein |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 26 |
| Locus
| Not Available |
| SNPs
| ACADSB |
| Gene Sequence
|
>1299 bp
ATGGAGCGAGCTACTGTTCGGCTGCTGCGCGGCGGCGCGCTGCTACGAAGAAACTTCCCA
AGCTGCCTGTCTTCCTGGAAAACTCCTCCTCATGCCCTAAATTCTTCTCAGTCAGAAGCT
CAGCTCAAAGCGACAAGCAATGGACCACCTCTTGCCCCTCTGCAAACATTTACGGATGAG
GAGATGATGATAAAGAGCGCAGTTAAAAAATTTGCCCAGGAACAAGTTGCTCCTTTTGTT
TCAAAAATGGATGAAGATTCAAAAATGGAAAAATCCGTAATACAAGGATTATTTCAACAA
GGGTTGATGGGTATTGAAATTGACACAAAATATGGAGGAACAGGAGCTTCATTTTTTTCC
TCTGTCCTAGTGATAGAGGAGTTAGCCAAAGTTGATGCATCTGTGGCTCTGGTATGTGAC
ATTCAGAACACATTAATTAACAGGATGATTGGAAAATATGGAACAGAAGAACAGAAGGCT
ACCTATTTGCCCAAGCTAGCTACAGAAAAGGCATCAAGTATCTGCATTTCAGAGACTGGA
GCAGGTAGCGATTCATTTGCTATGAAGACCAGAGCTGATAAAAAGGGAGATTATTACATC
ATCAATGGGTCAAAGATGTGGATTAGCAGTGCTGAGATTGCTGGGCTGTTCGTGGTGATG
GCAAATGCAGACTTTTCTGCTGGGTATAAAGGAATTACCTGCTTCTTGGTCGATGGTGAT
ACCGAGGGCCTTCATGTAGGGAAACCAGAGAACAAATTGGGAATCAGAGCATCTTCCACC
TGCCCAGTCACATTTGAAAATGTCAAGGTTCCAAAAACAAATATCCTGGGGCAAGTTGGG
CACGGCTATAAGTATGCCATCGGGAGTCTTAATGAAGGCAGAATAGGAATCGCTGCACAG
ATGCTGGGAGTGGCTCAAGGCTGTTTTGACTACACTATTCCATATATTAAAGAAAGGAAA
CAATTTGGCCGAAGGGTATTTGATTTTCAGGGGCTCCAACACCAAGTGGCTCACATGGCC
ACCCAGCTGGAAGCTGCTCGACTCCTGACATACAATGCTGCGAGGCTCTTAGAGGCTGGG
AGGCCGATGATTAAAGAAGCATCTATGGCCAAATACCATGCGTCAGAGCTGGCAGGCCTC
ATTACCAGCAAGTGTATCGAGTGGATGGGAGGAGTGGGCTACACCAAAAGTTACCCTGTG
GAAAAATATTTCCGAGATGCGAAGATTGGCACAATTTATGAAGGAACTTCAAATATCCAG
CTGAACACCATCGCAAAGTGCATCAGTGCGGAATACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 432 |
| Molecular Weight
| 47123.0 |
| Theoretical pI
| 8.65 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial
MERATVRLLRGGALLRRNFPSCLSSWKTPPHALNSSQSEAQLKATSNGPPLAPLQTFTDE
EMMIKSAVKKFAQEQVAPFVSKMDEDSKMEKSVIQGLFQQGLMGIEIDTKYGGTGASFFS
SVLVIEELAKVDASVALVCDIQNTLINRMIGKYGTEEQKATYLPKLATEKASSICISETG
AGSDSFAMKTRADKKGDYYIINGSKMWISSAEIAGLFVVMANADFSAGYKGITCFLVDGD
TEGLHVGKPENKLGIRASSTCPVTFENVKVPKTNILGQVGHGYKYAIGSLNEGRIGIAAQ
MLGVAQGCFDYTIPYIKERKQFGRRVFDFQGLQHQVAHMATQLEAARLLTYNAARLLEAG
RPMIKEASMAKYHASELAGLITSKCIEWMGGVGYTKSYPVEKYFRDAKIGTIYEGTSNIQ
LNTIAKCISAEY
|
| External Links |
|---|
| GenBank ID Protein
| AAI22699.1 |
| UniProtKB/Swiss-Prot ID
| Q5EAD4 |
| UniProtKB/Swiss-Prot Entry Name
| ACDSB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC122698 |
| GeneCard ID
| ACADSB |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
