| Identification |
|---|
| BMDB Protein ID
| BMDBP00852 |
| Secondary Accession Numbers
| None |
| Name
| Glutamine-dependent NAD(+) synthetase |
| Synonyms
|
Not Available
|
| Gene Name
| NADSYN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Coenzyme transport and metabolism |
| Specific Function
| Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. |
| Pathways
|
- Cofactor biosynthesis
- Glutamate Metabolism
- NAD(+) biosynthesis
- NAD(+) from deamido-NAD(+) (L-Gln route): step 1/1
- Nicotinate and Nicotinamide Metabolism
|
| Reactions
|
| Nicotinic acid adenine dinucleotide + Adenosine triphosphate + Water + L-Glutamine → NAD + Adenosine monophosphate + Pyrophosphate + L-Glutamic acid |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| NADSYN1 |
| Gene Sequence
|
>2121 bp
ATGGGGCGAAAGGTGACCGTGGCCACCTGTGCGCTCAACCAGTGGGCCCTGGACTTTGAG
GGCAATTTGCAAAGGATTTTAAAAAGTATTGAAATTGCCAAACACAGAGGAGCAAGATAC
AGGCTTGGACCAGAACTGGAAATCTGTGGCTACGGCTGTTGGGATCATTATTACGAGTCG
GACACCCTCCTGCATTCGCTCCAGGTCCTGGCGGCCCTTTTGGAGTCTCCGGTCACTCAG
GATATCATCTGCGACGTGGGGATGCCCGTGATGCACCGAAACGTCCGCTATAACTGCAGG
GTGATATTCCTCAACAGGAAGATCCTGCTCATCAGACCCAAGATGGCCTTGGCGAATGAG
GGCAACTACCGAGAGTTGCGCTGGTTCACGCCATGGTCCAGGAGCCGGCAAACAGAGGAG
TATTTTCTCCCCCGGATGTTACAGGACCTGACGAAGCAGGAAACTGTGCCCTTTGGGGAT
GCCGTCCTCTCCACATGGGACACCTGTATCGGGAGTGAGGTCTGTGAGGAGCTCTGGACG
CCCCACAGCCCACACGTGGACATGGGCCTGGACGGCGTGGAGATCTTCACCAACGCCTCG
GGTAGCCATCACGTGCTGCGCAAAGCCCACGCCCGGGTGGACCTGGTGACCATGGCTACC
ACCAAGAACGGCGGGATCTACTTGCTGGCCAATCAGAAGGGCTGCGATGGGGACCGGCTG
TATTACGACGGCTGTGCTCTCATAGCCATGAACGGCAGCATCTTTGCCCAGGGGTCCCAG
TTCTCTCTGGATGACGTGGAAGTGCTCACTGCCACGTTGGATTTGGAGGACATCAGAAGC
TACAGGGCGGAGATTTCATCTCGAAACCTGGCGGCCAGCAGGGTGAGCCCCTACCCCCGC
GTGAAGGTGGATTTCGCCCTCTCCTGCCATGAAGACCTGCTGGAGCCTGTGTCTGAGCCT
ATCGAGTGGAAATACCACAGTCCCGCCGAGGAGATCAGCCTGGGACCCGCGTGCTGGCTC
TGGGACTTCTTAAGACGCAGCCGACAGGCAGGGTTCTTCCTTCCCCTGAGCGGCGGGGTG
GACAGCGCGGCCACCGCCTGCCTGGTCTACTCCATGTGCCACCAGGTCTGCGAGGCTGTG
AAGCGTGGAAATCTGGAGGTGCTGGCTGATGTCCGAACCATCGTGAACCAGCTCAGCTAC
ACCCCCCAGGACCCCCGGGAGCTCTGCGGCCGCGTCCTGACCACCTGCTACATGGCCAGC
GAGAACTCCTCCCAGGAGACCTGCGACAGGGCCCGAGAGCTGGCCCAGCAGATTGGAAGC
CACCACATCGGTCTCCACATCGACCCAGTGGTCAAGGCCCTCGTGGGCCTCTTCAGCCTG
GTGACGGGTGCGAGCCCTCGGTTTGCGGTTCACGGAGGGAGCGACCGGGAGAACCTGGCT
CTGCAGAACGTCCAGGCGCGGGTGAGGATGGTCATCGCCTACCTCTTCGCTCAGCTGAGC
CTCTGGTCTCGCGGTGCCCCCGGCGGGCTTCTCGTGCTCGGATCCGCCAATGTGGACGAG
AGCCTCCTTGGCTACCTGACCAAGTACGACTGCTCCAGCGCTGACATCAACCCCATCGGC
GGGATCAGCAAGACGGACCTGAGAGCCTTCGTCCAGCTCTGCGTGGAGCGCTTCCAGCTT
CCTGCCCTGCAGAGCATCCTGGCAGCACCGGCCACAGCTGAGCTGGAGCCCCTGGCCCAC
GGACGGGTGTCCCAGACCGATGAGGAAGACATGGGGATGACATATGCGGAGCTGTCCGTC
TACGGGAGGCTCCGGAAGGTCGCCAAGACAGGCCCCTACAGCATGTTCTGCAAACTCCTC
GACATGTGGAGGGATACCTGCTCGCCCCGACAGGTGGCTGACAAAGTGAAGTGCTTTTTC
TCCAAGTATTCCATGAACAGACACAAGATGACCACACTGACCCCCGCATACCACGCCGAG
AGCTACAGCCCGGACGACAACAGGTTCGACCTGCGGCCATTTCTGTATAACACCCGCTGG
CCCTGGCAGTTCCGCTGCATCGAAAACCAGGTCCTCCAGCTGGAGGGGAGACAGCGGCAG
GAGCTAGACGGCGTGGACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 706 |
| Molecular Weight
| 79400.0 |
| Theoretical pI
| 6.46 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glutamine-dependent NAD(+) synthetase
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKHRGARYRLGPELEICGYGCWDHYYES
DTLLHSLQVLAALLESPVTQDIICDVGMPVMHRNVRYNCRVIFLNRKILLIRPKMALANE
GNYRELRWFTPWSRSRQTEEYFLPRMLQDLTKQETVPFGDAVLSTWDTCIGSEVCEELWT
PHSPHVDMGLDGVEIFTNASGSHHVLRKAHARVDLVTMATTKNGGIYLLANQKGCDGDRL
YYDGCALIAMNGSIFAQGSQFSLDDVEVLTATLDLEDIRSYRAEISSRNLAASRVSPYPR
VKVDFALSCHEDLLEPVSEPIEWKYHSPAEEISLGPACWLWDFLRRSRQAGFFLPLSGGV
DSAATACLVYSMCHQVCEAVKRGNLEVLADVRTIVNQLSYTPQDPRELCGRVLTTCYMAS
ENSSQETCDRARELAQQIGSHHIGLHIDPVVKALVGLFSLVTGASPRFAVHGGSDRENLA
LQNVQARVRMVIAYLFAQLSLWSRGAPGGLLVLGSANVDESLLGYLTKYDCSSADINPIG
GISKTDLRAFVQLCVERFQLPALQSILAAPATAELEPLAHGRVSQTDEEDMGMTYAELSV
YGRLRKVAKTGPYSMFCKLLDMWRDTCSPRQVADKVKCFFSKYSMNRHKMTTLTPAYHAE
SYSPDDNRFDLRPFLYNTRWPWQFRCIENQVLQLEGRQRQELDGVD
|
| External Links |
|---|
| GenBank ID Protein
| AAI03389.1 |
| UniProtKB/Swiss-Prot ID
| Q3ZBF0 |
| UniProtKB/Swiss-Prot Entry Name
| NADE_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC103388 |
| GeneCard ID
| NADSYN1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
