| Identification |
|---|
| BMDB Protein ID
| BMDBP00789 |
| Secondary Accession Numbers
| None |
| Name
| N-acylneuraminate cytidylyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| CMAS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in N-acylneuraminate cytidylyltransferase acti |
| Specific Function
| Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN) (By similarity). |
| Pathways
|
- Amino Sugar Metabolism
- Amino-sugar metabolism
- N-acetylneuraminate metabolism
|
| Reactions
|
| N-Acetylneuraminic acid + Cytidine triphosphate → Cytidine monophosphate N-acetylneuraminic acid + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| CMAS |
| Gene Sequence
|
>1305 bp
ATGGACTCGGTGGAGAAGGGGGCCGCCACCTCCGTCTCCAACCCGCGGGGGCGACCCTCT
CGGGGCCGGCCGCCGAAGCTACAGCGCAACTCCCGAGGCGGCCAGGGCCGAGGGGTGGAG
AAGCCCCCGCATATGGCGGCCCTCATCCTGGCCCGGGGCGGCAGCAAGGGCATCCCCCTG
AAGAACATTAAGCACCTGGCGGGGGTCCCGCTCATTGGCTGGGTCCTGCGTGCGGCCCTG
GACTCGGGGGTCTTCCAGAGTATATGGGTTTCAACAGACCATGATGAAATTGAGAATGTG
GCCAAACAGTTTGGTGCACAAGTTCATCGAAGAAGTTCTGAAGCTTCAAAAGACAGTTCT
ACCTCACTAGATGCCATCATAGAATTTCTTAATTATCACAATGAGGTTGACATTGTAGGA
AATATTCAAGCTACTTCTCCGTGTTTACATCCTACTGATCTTCAAAAAGTTGCAGAAATG
ATTCGAGAAGAAGGATACGATTCTGTTTTCTCTGTTGTGAGACGGCATCAGTTTCGATGG
GGTGAAATTCAGAAAGGAGTTCGTGAAATGACTGAGCCTCTGAATTTGAATCCAGCTAAA
CGACCTCGCCGGCAAGACTGGGATGGAGAATTATATGAAAATGGCTCATTTTATTTTGCT
AAAAGACATTTGATAGAGATGGGTTACTTACAGGGTGGGAAGATGGCGTACTACGAGATG
AGAGCCGAGCACAGTGTGGACATCGATGTGGACATTGATTGGCCTATTGCCGAACAAAGA
GTATTAAGATACGGTTATTTTGGCAAAGAGAAACTGAAGGAGATAAAACTTTTTGTTTGC
AATATTGATGGATGTCTCACCAATGGCCACATTTATGTATCAGGAGACCAAAAAGAAATA
ATATCTTATGATGTAAAAGATGCTATTGGGATAAGTTTATTAAAGAAAAGTGGTATTGAG
GTGAGGTTAATCTCAGAAAGGGCCTGTTCAAAGCAGACCCTCTCGTCCTTAAAACTGGAT
TGCAAAATGGAAGTCAATGTGCCAGATAAACTTGCAGTTGTAGATGAATGGAGAAAAGAA
ATGGGCCTGTGCTGGAAAGAAGTAGCATATCTTGGAAATGAAGTGTCTGATGAGGAGTGC
TTGAAGAAAGTGGGCCTCAGCGGCGTGCCTGCTGACGCCTGTGCCGCTGCCCAGAAGGCT
GTTGGATATATTTGCAAAAGCAGTGGAGGCCGAGGTGCCCTCCGAGAGTTTGCAGAGCAC
ATTTTCCTACTCATGGAAAAGGTTATCAATTCATGCCAAAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 434 |
| Molecular Weight
| 48438.0 |
| Theoretical pI
| 8.1 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N-acylneuraminate cytidylyltransferase
MDSVEKGAATSVSNPRGRPSRGRPPKLQRNSRGGQGRGVEKPPHMAALILARGGSKGIPL
KNIKHLAGVPLIGWVLRAALDSGVFQSIWVSTDHDEIENVAKQFGAQVHRRSSEASKDSS
TSLDAIIEFLNYHNEVDIVGNIQATSPCLHPTDLQKVAEMIREEGYDSVFSVVRRHQFRW
GEIQKGVREMTEPLNLNPAKRPRRQDWDGELYENGSFYFAKRHLIEMGYLQGGKMAYYEM
RAEHSVDIDVDIDWPIAEQRVLRYGYFGKEKLKEIKLFVCNIDGCLTNGHIYVSGDQKEI
ISYDVKDAIGISLLKKSGIEVRLISERACSKQTLSSLKLDCKMEVNVPDKLAVVDEWRKE
MGLCWKEVAYLGNEVSDEECLKKVGLSGVPADACAAAQKAVGYICKSSGGRGALREFAEH
IFLLMEKVINSCQK
|
| External Links |
|---|
| GenBank ID Protein
| AAI02787.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZM5 |
| UniProtKB/Swiss-Prot Entry Name
| NEUA_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102786 |
| GeneCard ID
| CMAS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
