| Identification |
|---|
| BMDB Protein ID
| BMDBP00785 |
| Secondary Accession Numbers
| |
| Name
| Pyruvate dehydrogenase protein X component |
| Synonyms
|
Not Available
|
| Gene Name
| PDHX |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
| Pathways
|
Not Available
|
| Reactions
|
| Pyruvic acid + Coenzyme A + NAD → Acetyl-CoA + Carbon dioxide + NADH |
details
|
| S-Acetyldihydrolipoamide-E + Coenzyme A → Dihydrolipoamide + Acetyl-CoA |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| PDHX |
| Gene Sequence
|
>1506 bp
ATGGCGGCCTCCTGGAGGCTAGGCTGTGACCCGCGGCTGCTGCGTTGCCTTCTGGGCTTT
GGCAGTCGCAGAAGCCCAGAGCTGGTTAAGGGGGCTGCTAGGTGGTCTGTCGGCCGTGGA
GCTAGTTGGAGATGGTTTCACAGTACGCAGTGGCTGCGGGCTGATCCTATTAAGATACTA
ATGCCATCACTGTCTCCTACAATGGAAGAAGGGAACATTGTGAAATGGCTGAAAAAGGAG
GGTGAAGCTGTGAGTGCTGGAGATGCCTTATGTGAAATAGAGACTGACAAAGCTGTGGTT
ACCTTAGATGCGAGTGATGATGGCATCTTGGCCAAAATAGTGGTGGCAGAAGGATCTAAA
AATATACGGTTGGGTTCACTGATTGGTTTGCTAGTTGAAGAAGGAGAAGATTGGAAACAT
GTTGAAATTCCTAAAGATACGGGTCCTCCACCACCAGCTGCAAAACCATCAGTGCCTCCC
CCCTCAGCAGAACCACAGATTGCTACCCCTGTCAAGAAGGAACACCCACCAGGAAAAGTG
CAGTTCCGTTTAAGTCCAGCTGCCCGCAATATTCTGGAAAAGCACGCACTGGATGCTAAC
CAGGGCACAGCCACTGGCCCTCGGGGGATATTCACTAAAGAGGATGCTCTCAAACTGGTC
CAGTTGAAACAGACGGGCAAGATCACTGAACCCAGACCCACCGCAGCCCTGCCAACCACT
CCCGCAGCGCCTTTGCCCCCACAGGCTGCAGCCACAGCATCTTACCCCCGGCCGATGATC
CCTCCTGTATCCACTCCCGGACAACCTAATGTAGAGGGCACATTCACTGAAATCCCAGCT
AGCAATATTAGAAGAGTTATTGCCAAGAGATTAACTGAATCTAAAAGCACCATACCTCAT
GCGTATGCTACTACTGACTGTGACCTTGGAGCTGTCCTAACAGCTAGACAGAATCTGGTC
AGAGATGACATTAAAGTATCAGTAAACGATTTTATCATCAAGGCAGCAGCTGTTACACTT
AAACAAATGCCTAATGTTAATGCAAGCTGGGACGGAGAGGGTGCAAAGCAACTGCCCTCT
ATTGACATTTCAGTGGCAGTGGCAACAGATAGAGGTCTAATTACACCAGTCATAAAAGAT
GCTGCTGCTAAGGGTCTACAGGAGATTGCTGATTCTGTAAAGGCTCTATCAAAGAAAGCC
AGAGATGGAAAATTGTTACCTGAAGAATATCAAGGAGGATCTTTTAGTATTTCCAACTTG
GGGATGTTTGGCATCGATGAATTTACTGCCGTGATCAACCCTCCTCAGGCCTGCATTTTG
GCGGTAGGGAGATTCCGACCTGTGCTGAAGCTCACTCAGGATGAAGAGGGGAATGCCCAG
CTGCAGCAACGTCAGCTCATAACGGTCACCATGTCCAGTGACAGCCGGGTGGTAGACGAT
GAACTGGCCACCAGGTTTCTGGAAAGTTTTAAAGCAAACCTGGAGAATCCTCTCCGACTT
GCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 501 |
| Molecular Weight
| 53886.0 |
| Theoretical pI
| 8.71 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- 389-407
- 410-426
- 442-471
- 536-555
- 574-594
- 640-659
- 726-750
- 772-810
|
| Protein Sequence
|
>Pyruvate dehydrogenase protein X component
MAASWRLGCDPRLLRCLLGFGSRRSPELVKGAARWSVGRGASWRWFHSTQWLRADPIKIL
MPSLSPTMEEGNIVKWLKKEGEAVSAGDALCEIETDKAVVTLDASDDGILAKIVVAEGSK
NIRLGSLIGLLVEEGEDWKHVEIPKDTGPPPPAAKPSVPPPSAEPQIATPVKKEHPPGKV
QFRLSPAARNILEKHALDANQGTATGPRGIFTKEDALKLVQLKQTGKITEPRPTAALPTT
PAAPLPPQAAATASYPRPMIPPVSTPGQPNVEGTFTEIPASNIRRVIAKRLTESKSTIPH
AYATTDCDLGAVLTARQNLVRDDIKVSVNDFIIKAAAVTLKQMPNVNASWDGEGAKQLPS
IDISVAVATDRGLITPVIKDAAAKGLQEIADSVKALSKKARDGKLLPEEYQGGSFSISNL
GMFGIDEFTAVINPPQACILAVGRFRPVLKLTQDEEGNAQLQQRQLITVTMSSDSRVVDD
ELATRFLESFKANLENPLRLA
|
| External Links |
|---|
| GenBank ID Protein
| AAI20414.1 |
| UniProtKB/Swiss-Prot ID
| P22439 |
| UniProtKB/Swiss-Prot Entry Name
| ODPX_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC120413 |
| GeneCard ID
| PDHX |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
