| Identification |
|---|
| BMDB Protein ID
| BMDBP00784 |
| Secondary Accession Numbers
| |
| Name
| Sorbitol dehydrogenase |
| Synonyms
|
Not Available
|
| Gene Name
| SORD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Polyol dehydrogenase that catalyzes the reversible NAD(+)-dependent oxidation of various sugar alcohols. Is mostly active with xylitol, D-sorbitol (D-glucitol) and L-iditol as substrates, leading to the C2-oxidized products D-xylulose, D-fructose and L-sorbose, respectively (PubMed:9143345). Is a key enzyme in the polyol pathway that interconverts glucose and fructose via sorbitol, which constitutes an important alternate route for glucose metabolism. May play a role in sperm motility by using sorbitol as an alternative energy source for sperm motility (By similarity). Cannot use NADP(+) as the electron acceptor. Has no activity on ethanol, methanol, glycerol, galactitol and fructose 6-phosphate (PubMed:9143345). |
| Pathways
|
Not Available
|
| Reactions
|
| Sorbitol + NAD → D-Fructose + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 10 |
| Locus
| Not Available |
| SNPs
| SORD |
| Gene Sequence
|
>1071 bp
ATGGCGGCGGCCAAGCCCGAGAACCTCTCCCTGGTGGTGCACGGACCCGGAGACTTGCGC
TTGGAAAACTATCCTATCCCTGAACCAGGCCCAAATGAGGTGCTTCTGAAGATGCATTCT
GTTGGAATTTGTGGCTCAGATGTCCATTACTGGCAGCATGGTCGAATTGGAGATTTTGTT
GTGAAAAAGCCAATGGTGCTGGGGCATGAAGCTTCAGGAACAGTCGTAAAAGTGGGATCA
TTGGTCAGGCACCTACAACCAGGTGATCGTGTCGCCATCGAGCCTGGTGCTCCTCGAGAA
ACTGATGAGTTCTGCAAGATTGGCCGATACAATCTGTCACCTACCATCTTCTTCTGCGCC
ACGCCCCCTGATGATGGGAACCTCTGCCGGTTCTACAAGCACAATGCTAACTTCTGCTAC
AAGCTTCCTGACAATGTCACCTTTGAGGAAGGGGCCCTGATTGAGCCACTGTCTGTGGGG
ATCCATGCCTGCCGGCGAGCTGGAGTCACGCTGGGGAACAAGGTCCTTGTGTGTGGAGCT
GGGCCAATTGGACTGGTCAGTTTGCTTGCAGCCAAGGCAATGGGTGCAGCTCAAGTGGTG
GTGACTGATCTGTCAGCCTCTCGGTTGTCTAAAGCCAAGGAAGTCGGGGCTGATTTCATC
CTCCAGATCTCCAACGAGAGCCCTCAGGAAATAGCCAAGAAAGTGGAAGGCCTGCTGGGC
AGCAAGCCAGAAGTCACAATTGAGTGCACAGGGGTGGAGACCTCCATCCAAGCCGGCATC
TACGCCACTCATTCTGGTGGGACCCTGGTGTTGGTGGGGCTGGGCTCTGAGATGACCAGC
GTGCCCCTCGTGCACGCAGCCACCAGGGAGGTGGACATCAAGGGCGTGTTTCGATACTGC
AATACATGGCCGATGGCGATTTCAATGCTTGCATCCAAGTCTGTGAATGTAAAGCCCTTG
GTCACCCATCGGTTTCCTCTGGAGAAAGCTCTGGAGGCCTTTGAAACATCCAAAAAGGGT
TTGGGGTTGAAAGTCATGATCAAGTGTGACCCCAACGACCAGAATCCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 356 |
| Molecular Weight
| 38099.0 |
| Theoretical pI
| 7.5 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Sorbitol dehydrogenase
MAAAKPENLSLVVHGPGDLRLENYPIPEPGPNEVLLKMHSVGICGSDVHYWQHGRIGDFV
VKKPMVLGHEASGTVVKVGSLVRHLQPGDRVAIEPGAPRETDEFCKIGRYNLSPTIFFCA
TPPDDGNLCRFYKHNANFCYKLPDNVTFEEGALIEPLSVGIHACRRAGVTLGNKVLVCGA
GPIGLVSLLAAKAMGAAQVVVTDLSASRLSKAKEVGADFILQISNESPQEIAKKVEGLLG
SKPEVTIECTGVETSIQAGIYATHSGGTLVLVGLGSEMTSVPLVHAATREVDIKGVFRYC
NTWPMAISMLASKSVNVKPLVTHRFPLEKALEAFETSKKGLGLKVMIKCDPNDQNP
|
| External Links |
|---|
| GenBank ID Protein
| AAX46613.1 |
| UniProtKB/Swiss-Prot ID
| Q58D31 |
| UniProtKB/Swiss-Prot Entry Name
| DHSO_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BT021766 |
| GeneCard ID
| SORD |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
