1.0 2018-05-07 22:23:55 UTC 2020-05-20 21:05:29 UTC BMDBP00768 Enzyme ATP6AP1 Involved in ATP binding Accessory subunit of the proton-transporting vacuolar (V)-ATPase protein pump, which is required for luminal acidification of secretory vesicles. Guides the V-type ATPase into specialized subcellular compartments, such as neuroendocrine regulated secretory vesicles or the ruffled border of the osteoclast, thereby regulating its activity. Involved in membrane trafficking and Ca(2+)-dependent membrane fusion. May play a role in the assembly of the V-type ATPase complex. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity). BMDB0001362 Hydrogen X >1407 bp ATGATGGCGGCGACCGCGGCGGCTCAGGTGCGGGCGGGGACGCGGTGGGCTCCAGCGCTC TGCCGGATGCCATGGCTGCCGCTGATGCTGGTGGCGGCGGCAGCGGCGACGTCGGAGCAG CAGGTGCCGCTGGTGCTGTGGTCGAGTGACCGAGGCCTGTGGGCTCCTGCGGCCGACACC CACGAGGGCCATATCACCAGCGACATGCAGCTCTCCACCTACTTAGACCCCGCCCTGGAG CTGGGCCCCCGAAATGTGCTGCTGTTCCTGCAGGACAAGCTGAGCATTGAGGACTTCACA GCATATGGTGGCGTGTTTGGAAACAAGCAAGACAGCGCCTTTTCTAACCTGGAGAACGCC CTGGACCTGGCCCCCTCCTCTCTGGTGCTTCCTGCTGTTGACTGGTACGCGATCAGCACT CTGACCACTTACCTGCAGGAGAAGCTCGGGGCCAGCCCCCTGCACGTGGACTTGGCCACT CTCCAGGAACTGAAGCTCAATGCCAGCATCCCGGCCTTGCTGCTCATCCGCCTGCCCTAC ACAGCCAGCTCGGGTCTGATGGCACCGAAGGAAGTCCTCATGGGCAATGATGAGGTCATT GGGCAGGTGCTGAGCACACTCAAGTCAGAAGACATCCCCTACACGGCGGCCCTCACGGCG GTCCGCCCTTCTAGGGTGGCCCGCGATGTAGCCATGGTGACTGGGGGGCTGGGTCGCCAG CTGTTGCAGAGAACGGTGGTGCCGCCTACAATGAATGTCCCCGTGAGTTACAATGACAGT TACGACACCCGGATCCTCTTCTGGGCCCAAAACTTCTCAGTGGCCTACGGGGAGCACTGG GAGGACCTGACCTCCCGCACCTTTGGGGTCCAGGACCTCAACCTGACTGGCTCCTTCTGG AATGACACCGTTGCCAGGCTGGTGCTGACATATGACTCACTCTTTGGGACCATGGTGACA TTCAAGTTCATTCTGGCTAACAGCTACTACTCAGTGTCTGCCCGGCACTGGTTTACCTTG GAGAACCTGGAAATCCACAGCAATGGCTCCGTCGCCTACTTCAATGCCTCCCAGGTCACG GGGCCCAGCATTTATTCCTTCCACTGTGAGCATGTCAGCAGTGAAAACGAGGATGGCAAC CTCCTTGTGCCTGACACGCAGCCCTCTCTTTGGCAGATGACTTTTCGGGACTTCCAGATC CAGGCCTTCAATGTGACAGACAAGAAGTTCTCCTATGCTAGCGACTGTGCAGGCTTCTTC TCCCCGGGTATCTGGATGGGGTTGCTCACCTCCTTGTTCATGCTGTTCATCTTCACCTAC GGCCTGCACATGATCCTCAGCCTCAAGACCATGGATCGCTTCGATGACCACAAGGGCCCC ACCATCACTTTGACCCAGATCGTGTGA 468 51781.0 4.78 418-438 1-35 >V-type proton ATPase subunit S1 MMAATAAAQVRAGTRWAPALCRMPWLPLMLVAAAAATSEQQVPLVLWSSDRGLWAPAADT HEGHITSDMQLSTYLDPALELGPRNVLLFLQDKLSIEDFTAYGGVFGNKQDSAFSNLENA LDLAPSSLVLPAVDWYAISTLTTYLQEKLGASPLHVDLATLQELKLNASIPALLLIRLPY TASSGLMAPKEVLMGNDEVIGQVLSTLKSEDIPYTAALTAVRPSRVARDVAMVTGGLGRQ LLQRTVVPPTMNVPVSYNDSYDTRILFWAQNFSVAYGEHWEDLTSRTFGVQDLNLTGSFW NDTVARLVLTYDSLFGTMVTFKFILANSYYSVSARHWFTLENLEIHSNGSVAYFNASQVT GPSIYSFHCEHVSSENEDGNLLVPDTQPSLWQMTFRDFQIQAFNVTDKKFSYASDCAGFF SPGIWMGLLTSLFMLFIFTYGLHMILSLKTMDRFDDHKGPTITLTQIV AAA50752.1 P40682 VAS1_BOVIN U10039 ATP6AP1