| Identification |
|---|
| BMDB Protein ID
| BMDBP00689 |
| Secondary Accession Numbers
| |
| Name
| Dihydropyrimidine dehydrogenase [NADP(+)] |
| Synonyms
|
Not Available
|
| Gene Name
| DPYD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. |
| Pathways
|
- Amino-acid biosynthesis
- Beta-alanine biosynthesis
|
| Reactions
|
| Dihydrouracil + NADP → Uracil + NADPH |
details
|
| Uracil + NADP → Dihydrouracil + NADPH |
details
|
| Thymine + NADP → Dihydrothymine + NADPH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 3 |
| Locus
| Not Available |
| SNPs
| DPYD |
| Gene Sequence
|
>3078 bp
ATGGCCCCTGTGCTAAGCAAGGACGTGGCGGATATCGAGAGTATCCTGGCTTTAAATCCT
CGAACACAGTCTCGTGCAACTCTGCGTTCCACTTTGGCCAAGAAATTAGACAAGAAACAT
TGGAAAAGAAATCCTGATAAGAACTGCTTTAATTGCGAGAAGCTGGAGAATAATTTTGAT
GACATCAAGCACACGACTCTTGGTGAGCGAGGAGCTCTCCGAGAAGCAATGAGATGCCTG
AAATGTGCAGATGCCCCCTGTCAGAAGAGCTGTCCAACAAATCTAGATATCAAATCGTTC
ATCACAAGTATCTCAAACAAGAACTATTATGGAGCTGCTAAGATGATATTTTCTGACAAC
CCACTTGGTCTGACCTGTGGAATGGTATGCCCCACCTCTGATCTTTGTGTAGGTGGATGT
AATTTGTATGCCACTGAAGAGGGACCAATTAATATTGGTGGATTGCAGCAATATGCTACT
GAGGTATTCAAAGCAATGAATATCCCACAAATCAGGAATCCTTCTCTGCCTCCCCCAGAA
AAAATGCCTGAAGCCTATTCTGCAAAGATTGCTCTTTTGGGTGCTGGGCCTGCAAGTATA
AGTTGTGCTTCGTTCTTGGCTCGATTAGGCTACAATGACATCACTATATTTGAAAAACAA
GAATACGTTGGTGGTATAAGTACTTCTGAAATCCCTCAGTTCCGGCTGCCATATGATGTA
GTAAATTTTGAGATTGAGCTTATGAAGGACCTTGGTGTAAAGATAATTTGTGGTAAAAGC
CTTTCAGTGAATGACATTACTCTTAGTACTTTGAAAGAAGAAGGGTACAAAGCTGCTTTC
ATTGGGATAGGTTTGCCAGAACCCAAGAAGGATCACATCTTCCAAGGCCTGACACAGGAC
CAGGGGTTTTACACTTCCAAAGACTTTCTGCCTCTTGTAGCCAAAAGCAGTAAAGCAGGA
ATGTGCGCCTGTCACTCTCCATTGCTGTCGATACGGGGAACCGTGATTGTACTCGGAGCT
GGAGACACAGCTTTCGACTGTGCAACATCCGCTTTACGTTGTGGAGCCCGCCGAGTGTTC
ATCGTCTTCAGAAAAGGCTTTGTTAATATAAGAGCTGTCCCTGAGGAGGTGGAGCTTGCT
AGAGAAGAAAAATGTGAATTTTTGCCTTTCTTGTCTCCACGGAAGGTTATAGTAAAAGGT
GGGAGAATTGTTGCCATGCAATTTGTTCGGACAGAGCAAGATGAAACTGGAAAATGGAAT
GAAGATGGAGATCAGATAGCCTGTCTGAAAGCCGATGTGGTCATCAGTGCCTTTGGCTCA
GTTCTGAGTGATCCTAAAGTAAAAGAAGCCTTGAGCCCTATAAAATTTAACAGATGGGAT
CTCCCAGAAGTAGATCCAGAAACTATGCAAACCAGTGAGCCATGGGTGTTTGCAGGTGGT
GATGTGGTTGGTATAGCCAACACTACAGTGGAAGCCGTGAATGATGGAAAGCAAGCCTCT
TGGTACATTCACAGATATATACAGTCACAATATGGAGCTTCAGTTTCTGCTAAGCCCGAA
CTCCCCCTGTTTTATACTCCCATTGATCTGGTGGACATTAGTGTGGAAATGGCTGCATTG
AAGTTTACAAATCCTTTTGGTCTTGCCAGTGCAACTCCAACTACCAGTTCGTCAATGATT
CGAAGAGCTTTTGAAGCTGGATGGGCCTTTGCTCTGACCAAAACTTTCTCTCTTGATAAG
GATATAGTGACAAATGTTTCACCCAGAATCATCCGGGGGACCACCTCTGGCCCCATGTAT
GGCCCTGGACAAAGCTCTTTCCTGAATATTGAGCTCATCAGTGAAAAAACGGCTGCATAT
TGGTGTCAAAGTGTCACTGAACTAAAAGCCGACTTTCCAGACAATATTGTGATTGCTAGC
ATCATGTGCAGTTACAACAGAAATGACTGGATGGAACTCTCCAGAAAGGCTGAGGCTTCT
GGAGCAGACGCCCTGGAGTTAAATTTATCGTGTCCGCATGGCATGGGAGAAAGAGGAATG
GGTCTGGCTTGTGGACAGGATCCAGAGCTGGTGCGGAACATCTGTCGCTGGGTTAGGCAA
GCTGTTCGGATTCCTTTTTTTGCCAAGTTGACCCCAAATGTCACTGATATTGTAAGCATA
GCCAGAGCTGCAAAGGAAGGTGGGGCAAATGGTGTTACAGCTACCAACACTGTCTCAGGT
CTCATGGGATTAAAAGCTGATGGCACACCCTGGCCAGCAGTGGGCCGTGAGAAGCGGACT
ACATACGGCGGAGTGTCCGGCACAGCCATCAGACCTATTGCTTTGAGAGCTGTGACCACC
ATTGCTCGTGCTTTGCCTGAATTTCCCATTTTGGCCACTGGTGGAATTGACTCAGCTGAA
AGTGGTCTTCAGTTTCTCCACGGTGGTGCTTCGGTGCTCCAGGTATGCAGTGCTATTCAA
AATCAGGATTTCACTATCATCCAAGACTACTGCACTGGCCTCAAAGCCTTGCTTTATCTG
AAAAGCATTGAAGAACTACAGGACTGGGATGGGCAGAGTCCAGCCACGAAGAGTCACCAG
AAAGGGAAACCAGTCCCTTGTATTGCTGAACTTGTGGGAAAGAAACTGCCAAGCTTTGGA
CCTTATCTTGAGAAGTGCAAGAAAATCATAGCAGAGGAAAAGTTGAGACTGAAAAAAGAA
AATGTGACCGTTCTACCACTTGAAAGAAACCATTTTATCCCAAAAAAACCTATTCCTTCT
GTTAAGGATGTGATTGGAAAAGCTCTGCAGTACCTTGGAACATATGGTGAACTGAACAAC
ACAGAGCAGGTTGTGGCTGTGATCGATGAAGAGATGTGTATCAACTGTGGCAAATGCTAC
ATGACCTGTAATGACTCTGGCTACCAGGCTATCCAGTTTGATCCTGAAACCCACCTGCCC
ACCGTTACTGACACTTGTACAGGCTGTACCCTGTGTCTCTCCGTCTGCCCTATTATCGAC
TGCATCAAAATGGTTTCCAGGACAACACCTTATGAACCAAAGAGAGGCTTGCCCTTGGCT
GTGAATCCTGTGTCTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 1025 |
| Molecular Weight
| 111697.0 |
| Theoretical pI
| 7.32 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dihydropyrimidine dehydrogenase [NADP+]
MAPVLSKDVADIESILALNPRTQSRATLRSTLAKKLDKKHWKRNPDKNCFNCEKLENNFD
DIKHTTLGERGALREAMRCLKCADAPCQKSCPTNLDIKSFITSISNKNYYGAAKMIFSDN
PLGLTCGMVCPTSDLCVGGCNLYATEEGPINIGGLQQYATEVFKAMNIPQIRNPSLPPPE
KMPEAYSAKIALLGAGPASISCASFLARLGYNDITIFEKQEYVGGISTSEIPQFRLPYDV
VNFEIELMKDLGVKIICGKSLSVNDITLSTLKEEGYKAAFIGIGLPEPKKDHIFQGLTQD
QGFYTSKDFLPLVAKSSKAGMCACHSPLLSIRGTVIVLGAGDTAFDCATSALRCGARRVF
IVFRKGFVNIRAVPEEVELAREEKCEFLPFLSPRKVIVKGGRIVAMQFVRTEQDETGKWN
EDGDQIACLKADVVISAFGSVLSDPKVKEALSPIKFNRWDLPEVDPETMQTSEPWVFAGG
DVVGIANTTVEAVNDGKQASWYIHRYIQSQYGASVSAKPELPLFYTPIDLVDISVEMAAL
KFTNPFGLASATPTTSSSMIRRAFEAGWAFALTKTFSLDKDIVTNVSPRIIRGTTSGPMY
GPGQSSFLNIELISEKTAAYWCQSVTELKADFPDNIVIASIMCSYNRNDWMELSRKAEAS
GADALELNLSCPHGMGERGMGLACGQDPELVRNICRWVRQAVRIPFFAKLTPNVTDIVSI
ARAAKEGGANGVTATNTVSGLMGLKADGTPWPAVGREKRTTYGGVSGTAIRPIALRAVTT
IARALPEFPILATGGIDSAESGLQFLHGGASVLQVCSAIQNQDFTIIQDYCTGLKALLYL
KSIEELQDWDGQSPATKSHQKGKPVPCIAELVGKKLPSFGPYLEKCKKIIAEEKLRLKKE
NVTVLPLERNHFIPKKPIPSVKDVIGKALQYLGTYGELNNTEQVVAVIDEEMCINCGKCY
MTCNDSGYQAIQFDPETHLPTVTDTCTGCTLCLSVCPIIDCIKMVSRTTPYEPKRGLPLA
VNPVS
|
| External Links |
|---|
| GenBank ID Protein
| AAB40985.1 |
| UniProtKB/Swiss-Prot ID
| Q28007 |
| UniProtKB/Swiss-Prot Entry Name
| DPYD_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| U20981 |
| GeneCard ID
| DPYD |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
