| Identification |
|---|
| BMDB Protein ID
| BMDBP00680 |
| Secondary Accession Numbers
| None |
| Name
| Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 |
| Synonyms
|
Not Available
|
| Gene Name
| ALKBH3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Replication, recombination and repair |
| Specific Function
| Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine (m1A). Repairs alkylated DNA containing 1-methyladenosine (m1A) and 3-methylcytosine (m3C) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3. Also acts on RNA. Demethylates N(1)-methyladenosine (m1A) RNA, an epigenetic internal modification of messenger RNAs (mRNAs) highly enriched within 5'-untranslated regions (UTRs) and in the vicinity of start codons. Requires molecular oxygen, alpha-ketoglutarate and iron. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| Not Available |
| SNPs
| ALKBH3 |
| Gene Sequence
|
>861 bp
ATGGAGGACAAAAGACGGCGAGCCCGAGTGCAGGGAGCCTGGGCTGGTCCTGCTAAGAGC
CAGGCCACTGCTCAGCCAGCTCCCACTGCTGAGAACAATCTCCAACAGAGACCTGGTAAA
GCCTGGATGAACAAGGAGCAGCATCTGTCTGACAGACAGTTTGTGTTCAAAGAACCCCAG
GAGGGGGTACGCAGAGCCCCAGAGCCACGAGTGATTGAAAAAGAGGGTGTGTATGAAATC
AGCATGTCACCCACAGGCATATCTAGGGTGTGTTTGTGTCCTGGCTTTGTTGACTTGAAA
GAGGCCGACTCAGTGTTTGAACAGCTTTGTCGGGATGTTCCCTGGAAGCAGAGGACTGGC
ATCAGAGACGATGTAACTTACCAGCAACCAAGACTTACAGCATGGTATGGAGAACTTCCT
TACACTTATTCAAGAATCACTATGGAACCAAATCCTCACTGGCATCCTGTGCTGCTCATG
CTGAAGAACCAAATTGAAGAGAACACTGGCCACAGCTTCAACTCCTTGCTTTGCAATCTT
TACCGAAATGAGAAGGACAGCGTGGACTGGCACAGCGATGATGAACCTTCACTGGGGAGG
TGCCCCATCATTGCTTCACTCAGTTTTGGTGCCACACGCATGTTTGAGATGAGAAAGAAG
CCCCCACCAGAAGACAATGGAGACTACACGTATGTGGAGAGAGTGAAGATACCCTTGGAT
CATGGGACCCTGTTAATCATGGAAGGGGCCACGCAGGCAGACTGGCAGCATCGAGTGCCC
AAAGAGTACCACTCCAGAGAACCAAGAATAAACTTGACCTTTCGGACAGTTTATCCTGAC
CCTCGAGGGGCGCACTGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 286 |
| Molecular Weight
| 33156.0 |
| Theoretical pI
| 7.59 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
MEDKRRRARVQGAWAGPAKSQATAQPAPTAENNLQQRPGKAWMNKEQHLSDRQFVFKEPQ
EGVRRAPEPRVIEKEGVYEISMSPTGISRVCLCPGFVDLKEADSVFEQLCRDVPWKQRTG
IRDDVTYQQPRLTAWYGELPYTYSRITMEPNPHWHPVLLMLKNQIEENTGHSFNSLLCNL
YRNEKDSVDWHSDDEPSLGRCPIIASLSFGATRMFEMRKKPPPEDNGDYTYVERVKIPLD
HGTLLIMEGATQADWQHRVPKEYHSREPRINLTFRTVYPDPRGAHW
|
| External Links |
|---|
| GenBank ID Protein
| AAI09833.1 |
| UniProtKB/Swiss-Prot ID
| Q32L00 |
| UniProtKB/Swiss-Prot Entry Name
| ALKB3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109832 |
| GeneCard ID
| ALKBH3 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
