| Identification |
|---|
| BMDB Protein ID
| BMDBP00666 |
| Secondary Accession Numbers
| None |
| Name
| 3-hydroxyanthranilate 3,4-dioxygenase |
| Synonyms
|
Not Available
|
| Gene Name
| HAAO |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in 3-hydroxyanthranilate 3,4-dioxygenase activity |
| Specific Function
| Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. |
| Pathways
|
- Cofactor biosynthesis
- NAD(+) biosynthesis
- Quinolinate from L-kynurenine: step 3/3
- Tryptophan Metabolism
- Tyrosine Metabolism
|
| Reactions
|
| 3-Hydroxyanthranilic acid + Oxygen → 2-Amino-3-carboxymuconic acid semialdehyde |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| HAAO |
| Gene Sequence
|
>861 bp
ATGGAGCGCCCAGTGAGAGTGAAGGCGTGGGTGGAGGAGAACCGGGGCTCCTTCCTGCCC
CCGGTCTGCAACAAGCTCCTGCACCAGAAGCAGCTCAAAATCATGTTCGTGGGGGGTCCC
AACACCAGGAAGGACTACCACATCGAGGAGGGTGAGGAGGTATTTTACCAGCTGGAGGGG
GACATGCTTCTCCGAGTCCTGGAGCGAGGGAAACACCGGGATGTGGTCATTCGTCAGGGA
GAGATCTTCCTGCTGCCTGCTGGGGTCCCCCACTCGCCGCAGAGGTTTGCCAACACAGTG
GGGCTGGTGATTGAGCGGAGGCGGCTGAAAACAGAACTAGATGGGCTCAGGTACTACGTA
GGGGACACCACGGACGTCCTGTTTGAGAAGTGGTTCTACTGCGAGGACCTCGGCACGCAG
TTGGCCCCCATCATCCAGGAGTTCTTCAGCTCTGAGCAGTACAGAACGGGAAAGCCCAAC
CCTGACCAGCTGCTCAAGGAACCACCATTCCCCCTGAGCACACGATCCGTCATGGAGCCC
ATGTGCCTGGAGGCCTGGCTGGATGGCCACCGCAAAGAGCTGCAGGCGGGCACACCCCTC
AGCTTGTTTGGGGACACCTATGAGAGCCAGGTGATGGTCCACGGACAAGGCAGCAGCGAA
GGCCTGAGACGGGACGTGGACGTGTGGCTGTGGCAGCTGGAGGGCTCCTCAGTGGTGACG
ATGGAAGGACAGCGCCTGAGCCTGACCCTTGATGACAGCCTCCTGGTGCCAGCTGGGACT
CTGTATGGCTGGGAGCGAGGGCAAGGCTCCGTGGCCCTGTCTGTGACCCAGGATCCCGCC
TGCAAGAAGTCCCTGGGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 286 |
| Molecular Weight
| 32493.0 |
| Theoretical pI
| 5.45 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>3-hydroxyanthranilate 3,4-dioxygenase
MERPVRVKAWVEENRGSFLPPVCNKLLHQKQLKIMFVGGPNTRKDYHIEEGEEVFYQLEG
DMLLRVLERGKHRDVVIRQGEIFLLPAGVPHSPQRFANTVGLVIERRRLKTELDGLRYYV
GDTTDVLFEKWFYCEDLGTQLAPIIQEFFSSEQYRTGKPNPDQLLKEPPFPLSTRSVMEP
MCLEAWLDGHRKELQAGTPLSLFGDTYESQVMVHGQGSSEGLRRDVDVWLWQLEGSSVVT
MEGQRLSLTLDDSLLVPAGTLYGWERGQGSVALSVTQDPACKKSLG
|
| External Links |
|---|
| GenBank ID Protein
| AAI20266.1 |
| UniProtKB/Swiss-Prot ID
| Q0VCA8 |
| UniProtKB/Swiss-Prot Entry Name
| 3HAO_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC120265 |
| GeneCard ID
| HAAO |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
