| Identification |
|---|
| BMDB Protein ID
| BMDBP00643 |
| Secondary Accession Numbers
| None |
| Name
| Serine/threonine-protein phosphatase PP1-alpha catalytic subunit |
| Synonyms
|
Not Available
|
| Gene Name
| PPP1CA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Signal transduction mechanisms |
| Specific Function
| Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Regulates NEK2 function in terms of kinase activity and centrosome number and splitting, both in the presence and absence of radiation-induced DNA damage. Regulator of neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E (By similarity). Dephosphorylates CENPA (By similarity). Dephosphorylates the 'Ser-139' residue of ATG16L1 causing dissociation of ATG12-ATG5-ATG16L1 complex, thereby inhibiting autophagy (By similarity). |
| Pathways
|
- Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
- Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
- Excitatory Neural Signalling Through 5-HTR 7 and Serotonin
- Intracellular Signalling Through FSH Receptor and Follicle Stimulating Hormone
- Intracellular Signalling Through Histamine H2 Receptor and Histamine
- Intracellular Signalling Through LHCGR Receptor and Luteinizing Hormone/Choriogonadotropin
|
| Reactions
|
| Ethylene-responsive transcription factor ESR1 + Hydrogen phosphate → Ethylene-responsive transcription factor ESR1 |
details
|
| Cyclic AMP-responsive element-binding protein 1 + Hydrogen phosphate → Cyclic AMP-responsive element-binding protein 1 |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| PPP1CA |
| Gene Sequence
|
>993 bp
ATGTCCGACAGCGAGAAGCTCAACCTGGACTCTATAATCGGACGCCTGCTGGAAGTGCAG
GGCTCCAGGCCTGGAAAGAATGTACAGCTGACGGAGAACGAGATCCGTGGTCTGTGCCTC
AAATCCCGGGAGATTTTCCTGAGCCAGCCCATTCTTCTGGAGCTGGAGGCACCCCTCAAG
ATCTGCGGTGACATTCATGGCCAGTACTATGATCTTCTGCGGCTGTTCGAGTACGGTGGC
TTCCCTCCAGAGAGTAACTACTTGTTCCTGGGGGACTACGTGGACAGGGGCAAGCAGTCT
TTGGAGACCATCTGCCTGCTGCTGGCCTATAAGATCAAGTACCCAGAGAACTTCTTCCTG
CTCCGTGGGAACCACGAGTGTGCCAGCATCAACCGCATCTACGGCTTCTATGATGAGTGC
AAGAGACGCTACAACATCAAACTGTGGAAGACCTTCACTGATTGCTTCAACTGCCTGCCC
ATCGCTGCCATCGTGGACGAGAAGATCTTCTGTTGCCATGGAGGGCTGTCCCCAGACCTA
CAGTCCATGGAGCAGATCCGGCGTATCATGCGGCCCACAGATGTGCCTGACCAGGGCCTG
CTCTGTGACCTGCTGTGGTCTGACCCTGACAAGGACGTGCAGGGCTGGGGTGAGAATGAC
CGCGGCGTCTCCTTTACATTTGGAGCTGAGGTGGTGGCCAAGTTCCTGCACAAGCATGAC
CTGGACCTCATCTGCCGGGCACACCAGGTAGTAGAAGACGGCTATGAGTTCTTTGCCAAG
CGGCAGCTGGTGACACTCTTTTCAGCCCCCAACTACTGCGGCGAGTTTGACAATGCAGGT
GCCATGATGAGTGTGGACGAGACGCTCATGTGCTCCTTCCAGATCCTCAAGCCCGCTGAC
AAGAACAAGGGGAAATACGGGCAGTTCAGTGGCCTGAACCCTGGAGGCCGGCCCATCACC
CCACCCCGCAACTCCGCCAAAGCCAAGAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 330 |
| Molecular Weight
| 37512.0 |
| Theoretical pI
| 6.25 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Serine/threonine-protein phosphatase PP1-alpha catalytic subunit
MSDSEKLNLDSIIGRLLEVQGSRPGKNVQLTENEIRGLCLKSREIFLSQPILLELEAPLK
ICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFL
LRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDL
QSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVQGWGENDRGVSFTFGAEVVAKFLHKHD
LDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAD
KNKGKYGQFSGLNPGGRPITPPRNSAKAKK
|
| External Links |
|---|
| GenBank ID Protein
| AAI02425.1 |
| UniProtKB/Swiss-Prot ID
| Q3T0E7 |
| UniProtKB/Swiss-Prot Entry Name
| PP1A_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC102424 |
| GeneCard ID
| PPP1CA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
