| Identification |
|---|
| BMDB Protein ID
| BMDBP00631 |
| Secondary Accession Numbers
| None |
| Name
| Alpha-aminoadipic semialdehyde synthase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| AASS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Bifunctional enzyme that catalyzes the first two steps in lysine degradation. The N-terminal and the C-terminal contain lysine-oxoglutarate reductase and saccharopine dehydrogenase activity, respectively (By similarity). |
| Pathways
|
- Amino-acid degradation
- Glutaryl-CoA from L-lysine: step 1/6.
- Glutaryl-CoA from L-lysine: step 2/6
- L-lysine degradation via saccharopine pathway
- Lysine Degradation
|
| Reactions
|
| L-Lysine + NADPH + Oxoglutaric acid → Saccharopine + NADP + Water |
details
|
| Saccharopine + Water + NAD → Allysine + L-Glutamic acid + NADH |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| Not Available |
| SNPs
| AASS |
| Gene Sequence
|
>2781 bp
ATGCTGCGAGTGTCCAGAACCAAACTGGGCAGGCTGAGCCCCAGCCTCTCCAGAGGGCTT
CACCACAAGGCGGTGATGGCCTTGAGGCGGGAGGATGTGAATGCCTGGGAAAGGCGGGCT
CCTCTGGCTCCCCGGCACGTCAAAGGGATCACCAACCTGGGATACAAGGTCTTAATACAG
CCTTCCAATCGGCGAGCCATTCACGATAAGGAATATGTCAAAGCTGGTGGCATTCTCCAA
GAGGATATTTCTGAAGCTTGTCTAATTTTGGGAGTTAAAAGACCGCCAGAGGAAAAATTA
ATGCCCAAGAAGACTTATGCATTCTTCTCCCACACAATAAAGGCTCAGGAGGCCAATATG
GGTTTGCTGGATGAGATCCTAAAACAGGAAATCCGACTTATTGATTATGAGAAAATGGTG
GATCATAGAGGAATACGGGTGGTGGCATTCGGACAGTGGGCAGGTGTGGCAGGAATAATC
AACATTCTTCATGGGATGGGTTTAAGGCTCCTTGCTTTGGGACATCACACACCTTTTATG
CACATTGGCATGGCTCATAACTACAGGAACAGTGGTCAGGCTGTGCAAGCTGTCCGCGAT
GCTGGCTATGAAATATCTTTGGGTTTGATGCCGAAGTCAATAGGGCCCTTAACATTTGTG
TTCACAGGGACTGGTAATGTATCTAAGGGAGCCCAAGAAATCTTCAATGAATTACCTTGT
GAGTATGTGGAGCCACATGAATTAAAAGAAGTTTCCCAAAATGGAGACCTGAGAAAAGTG
TACGGGACAGTGTTAAGTCGCCATCATCATCTTGTCAGGAAAACAGATGGTGTATATGAC
CCTGTAGAGTATGACAAATACCCCGAGCGCTACATTAGCCGTTTTAATACTGATATTGCA
CCCTATACAACTTGTTTAATTAACGGGATCTACTGGGAACAGAACACCCCTCGTCTACTC
ACCCGCCAAGATGCTCAGAGTCTCCTGGCTCCAGGCAAGTCCCCAGTTGCTGGTGTTGAA
GGCTGCCCTGCATTGCCACACAAACTTGTGGCAATATGTGACATTTCAGCGGACACAGGA
GGATCCATTGAGTTTATGACTGAGTGTACGACCATAGAGCGTCCCTTTTGCATGTATGAT
GCAGATCAGCATATTATTCATGACAGTGTGGAAGGCTCTGGGATTCTGATGTGTTCCATT
GACAATTTGCCAGCACAGCTTCCAATTGAATCTACAGAATACTTTGGAGACATGCTTTAC
CCTTATGTTGAAGAAATGATACTATCAGATGCGACACAGCCTCTTGAAAGTCAGAATTTT
TCTCCTGTGGTGCGAGATGCAGTGATTGCATCTAATGGCATGCTGTCTAACAAGTATAAA
TATATCCAGAAACTCCGAGAGAACAGGGAACATGCTCAGTCACTTTCAATGGGCACCAAG
AAAAAGGTCTTGGTTCTTGGATCTGGTTACGTTTCTGAGCCTGTATTGGAATACCTGTTG
AGAGATGACAGTATTGAAATAACAGTAGGTTCTGACATGAAGAATCAAATTGAACAATTA
GGCAAGAAATATAATATTAATCCTGTTAGCCTGCACGTTGGTAAACAAGAAGAGAAGTTG
AGCTCCTTGGTGGCAACACAGGATCTTGTCATCAGCTTATTGCCTTATGTATTGCATCCT
CTTGTGGCCAAGGCATGCATCGCAAGCAAAGTTAACATGATCACTGCAAGCTACATCACC
CCAGCGCTAAAAGAATTAGAAAAGAGTGTGGAAGATGCTGGCATCACAGTCATTGGTGAA
TTGGGATTGGACCCTGGTCTTGATCATATGTTGGCAATGGAAACAATAGATAAGGCCAAA
GAAGTGGGAGCCACGATTGAATCTTATGTTTCCTACTGCGGTGGCCTTCCAGCTCCTGAA
TGTTCAGACAATCCTTTGAGATACAAATTTAGCTGGAGTCCAGTGGGAGTTCTGATGAAC
ATAATGCAGCCCGCTACCTACCTGCTCAACGGAAAGGTTGTGAATGCTGTAGGAGGTGTC
TCCTTTCTGGATTCAGTCACTCCCATGGATTATTTCCCTGGATTAAATTTGGAAGGTTAT
CCTAACAGAGACAGTACGAAGTATGCTGAGATTTATGGCATTCCATCTGCTCACACTTTA
TTACGAGGGACACTGAGGTACAAGGGGTATGCCAAAGCTTTGAGTGGATTTGTGAAGTTG
GGTCTCATAAACAGAGATGCGTTTCCTGCCCTTCAACCTGATGCCAATCCGCTCACCTGG
AAAGAACTCCTCTGTGATCTAGTTGGGATTTCATCCTCTTCCAAATGTGATGTGCTTAAG
GAAGCTGTCTTTAAGAAACTGGGAGGAGACACAACCCAGTTGGAGGCTCTCGAATGGTTA
GGGCTACTCGGGGATGAACAAGTCCCTCAGGCCGAGTCTCTCGTGGATGCCCTCTCCAAG
CATCTGGCCGTGAAACTTTCCTATGGTCCTGGAGAGAAAGATATGATTGTGATGAGAGAC
AGCTTTGGAATCAGACATCCTTCTGGACATTTGGAAAATAAAACTATTGATCTTGTGGTT
TATGGGGATGTCAATGGTTTTTCAGCCATGGCTAAAACTGTGGGGTTACCCACTGCTATG
GCAGCCAAGATGTTACTTGATGGTGAAATTCAAGCTAAAGGCCTGATGGGACCCTTTTCA
AAGGAGATCTATGGACCAATATTGGAGCGAATTAAAGCAGAAGGCATTATGTATACTACA
CAGAGCACAATCAAACTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 926 |
| Molecular Weight
| 102084.0 |
| Theoretical pI
| 6.7 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alpha-aminoadipic semialdehyde synthase, mitochondrial
MLRVSRTKLGRLSPSLSRGLHHKAVMALRREDVNAWERRAPLAPRHVKGITNLGYKVLIQ
PSNRRAIHDKEYVKAGGILQEDISEACLILGVKRPPEEKLMPKKTYAFFSHTIKAQEANM
GLLDEILKQEIRLIDYEKMVDHRGIRVVAFGQWAGVAGIINILHGMGLRLLALGHHTPFM
HIGMAHNYRNSGQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQEIFNELPC
EYVEPHELKEVSQNGDLRKVYGTVLSRHHHLVRKTDGVYDPVEYDKYPERYISRFNTDIA
PYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKSPVAGVEGCPALPHKLVAICDISADTG
GSIEFMTECTTIERPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIESTEYFGDMLY
PYVEEMILSDATQPLESQNFSPVVRDAVIASNGMLSNKYKYIQKLRENREHAQSLSMGTK
KKVLVLGSGYVSEPVLEYLLRDDSIEITVGSDMKNQIEQLGKKYNINPVSLHVGKQEEKL
SSLVATQDLVISLLPYVLHPLVAKACIASKVNMITASYITPALKELEKSVEDAGITVIGE
LGLDPGLDHMLAMETIDKAKEVGATIESYVSYCGGLPAPECSDNPLRYKFSWSPVGVLMN
IMQPATYLLNGKVVNAVGGVSFLDSVTPMDYFPGLNLEGYPNRDSTKYAEIYGIPSAHTL
LRGTLRYKGYAKALSGFVKLGLINRDAFPALQPDANPLTWKELLCDLVGISSSSKCDVLK
EAVFKKLGGDTTQLEALEWLGLLGDEQVPQAESLVDALSKHLAVKLSYGPGEKDMIVMRD
SFGIRHPSGHLENKTIDLVVYGDVNGFSAMAKTVGLPTAMAAKMLLDGEIQAKGLMGPFS
KEIYGPILERIKAEGIMYTTQSTIKL
|
| External Links |
|---|
| GenBank ID Protein
| AAI53852.1 |
| UniProtKB/Swiss-Prot ID
| A8E657 |
| UniProtKB/Swiss-Prot Entry Name
| AASS_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC153851 |
| GeneCard ID
| AASS |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
