| Identification |
|---|
| BMDB Protein ID
| BMDBP00627 |
| Secondary Accession Numbers
| None |
| Name
| Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| SUCLG2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| GTP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. |
| Pathways
|
- Carbohydrate metabolism
- Citric Acid Cycle
- Succinate from succinyl-CoA (ligase route): step 1/1
- Tricarboxylic acid cycle
- Warburg Effect
|
| Reactions
|
| Succinyl-CoA + Hydrogen phosphate + Guanosine diphosphate → Succinic acid + Coenzyme A + Guanosine triphosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 22 |
| Locus
| Not Available |
| SNPs
| SUCLG2 |
| Gene Sequence
|
>1299 bp
ATGGCGGCCCCCGTGGGAGCGCAGGCCCGGAAACTTCTGAGAGACCTGGTGCTCCGGCCC
CCGCTCCTGGCGGCCAGGTCCCAGGTGGTTCAATTAACATCCAGAAGATGGCTGAACCTG
CAGGAATACCAGAGTAAGAAATTAATGTCTGACAACGGAGTGAAAGTTCAAAGATTCTTT
GTTGCCGACACTGCCAATGAAGCTCTGGAGGCTGCTAAGAGACTAAATGCAAAAGAAATT
GTTTTAAAAGCCCAGATCTTAGCTGGCGGAAGAGGAAAAGGTGTCTTCAGTAGCGGTTTG
AAAGGAGGCGTTCATTTAACAAAAGACCCTAAAGTTGTGGGACAGCTGGCTAAACAGATG
ATTGGATATAATCTAGCAACAAAACAAACTCCAAAAGAAGGTGTGAAAGTTAAAAAGGTG
ATGGTTGCTGAAGCCCTGGACATTTCCAGGGAAACCTACTTGGCCATTCTGATGGACCGG
TCCTGCAATGGCCCTGTGCTGGTGGGCAGCCCTCAGGGGGGCGTTGACATTGAAGAGGTG
GCAGCTTCGAATCCAGAACTTATTTTTAAGGAGCAAATTGACATTATTGAAGGGATAAAG
GACAGCCAAGCTCAGCGGATGGCGGAAAATCTAGGCTTCCTTGGGCCTTTGAAAAACCAG
GCTGCAGATCAAATTAAGAAGCTGTACAATCTCTTCCTGAAAATTGATGCTACTCAGGTG
GAAGTGAATCCCTTTGGTGAAACTCCAGAAGGACAAGTTGTCTGTTTTGATGCCAAGATA
AACTTTGATGACAACGCAGAATTCCGACAAAAGGATATATTTGCTATGGATGACAAATCA
GAGAATGAGCCCATTGAAAATGAAGCTGCCAGATATGATCTAAAATACATAGGACTGGAT
GGGAACATTGCCTGTTTTGTTAATGGTGCTGGACTCGCCATGGCTACCTGTGACATCATT
TTCCTGAATGGTGGGAAGCCAGCCAACTTTTTGGATCTTGGTGGTGGTGTAAAGGAATCT
CAAGTATATCAAGCATTCAAATTACTCACAGCTGATCCTAAGGTTGAAGCCATCCTAGTC
AATATTTTTGGTGGAATTGTCAACTGTGCCATCATTGCCAATGGGATCACCAAAGCCTGC
CGGGAGCTGGAGCTCAAGGTGCCACTGGTGGTCCGGCTTGAAGGAACCAACGTCCACGAG
GCCCAGAACATTCTCAGTAACAGCGGACTCCCCATCACTTCAGCTGTCGACCTGGAGGAT
GCAGCCAAGAAAGCTGTTGCCAGTGTGGCTAAGAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 432 |
| Molecular Weight
| 46691.0 |
| Theoretical pI
| 7.76 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial
MAAPVGAQARKLLRDLVLRPPLLAARSQVVQLTSRRWLNLQEYQSKKLMSDNGVKVQRFF
VADTANEALEAAKRLNAKEIVLKAQILAGGRGKGVFSSGLKGGVHLTKDPKVVGQLAKQM
IGYNLATKQTPKEGVKVKKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEV
AASNPELIFKEQIDIIEGIKDSQAQRMAENLGFLGPLKNQAADQIKKLYNLFLKIDATQV
EVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAARYDLKYIGLD
GNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKESQVYQAFKLLTADPKVEAILV
NIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTNVHEAQNILSNSGLPITSAVDLED
AAKKAVASVAKK
|
| External Links |
|---|
| GenBank ID Protein
| AAI04560.1 |
| UniProtKB/Swiss-Prot ID
| Q3MHX5 |
| UniProtKB/Swiss-Prot Entry Name
| SUCB2_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC104559 |
| GeneCard ID
| SUCLG2 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
