| Identification |
|---|
| BMDB Protein ID
| BMDBP00603 |
| Secondary Accession Numbers
| None |
| Name
| Xanthine dehydrogenase/oxidase |
| Synonyms
|
Not Available
|
| Gene Name
| XDH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| Not Available |
| SNPs
| XDH |
| Gene Sequence
|
>3999 bp
ATGACAGCAGATGAATTGGTTTTCTTTGTGAATGGCAAAAAGGTGGTGGAGAAAAATGCA
GATCCAGAAACAACCCTTTTGGCCTACCTGAGAAGAAAGTTGGGGCTGAGAGGAACCAAG
CTGGGCTGTGGAGAAGGGGGCTGTGGGGCTTGTACAGTGATGCTTTCCAAGTATGATCGT
CTCCAAGACAAGATCATCCACTTTTCTGCCAATGCCTGCCTGGCTCCCATCTGCACCTTG
CACCACGTGGCTGTGACGACTGTGGAAGGAATTGGAAGCACCAAGACGAGGCTGCATCCT
GTGCAGGAGAGAATCGCCAAAAGTCACGGCTCTCAGTGTGGGTTCTGCACCCCCGGCATC
GTCATGAGCATGTACACACTGCTTCGGAATCAGCCCGAGCCCACTGTTGAAGAAATCGAG
GATGCTTTCCAAGGAAACTTATGCCGCTGTACAGGCTACAGACCCATCCTCCAGGGCTTC
CGGACCTTTGCCAAGAATGGTGGATGCTGTGGAGGAAATGGGAACAACCCAAACTGCTGC
ATGAACCAGAAGAAAGACCACACCGTTACTCTCTCACCATCTTTATTCAACCCAGAGGAG
TTCATGCCCCTGGATCCTACCCAGGAACCCATCTTCCCTCCAGAGTTGCTGAGGCTGAAA
GACGTTCCACCGAAGCAGCTGCGTTTTGAAGGGGAGCGTGTGACCTGGATCCAAGCCTCC
ACCTTGAAGGAGTTGCTGGACCTCAAAGCTCAGCATCCCGAGGCCAAGCTGGTGGTGGGG
AACACAGAGATCGGCATTGAGATGAAGTTTAAGAATCAGCTATTTCCTATGATCATCTGC
CCAGCCTGGATCCCTGAGCTGAATGCAGTGGAGCACGGACCTGAGGGGATCTCCTTTGGA
GCTGCTTGTGCCCTGAGCTCTGTGGAAAAGACCCTGCTCGAGGCCGTTGCCAAGCTTCCC
ACCCAGAAAACGGAGGTGTTCAGAGGAGTCCTGGAGCAGCTGCGCTGGTTCGCTGGGAAG
CAGGTCAAGTCTGTGGCGTCCCTTGGAGGGAACATCATCACAGCCAGCCCCATCTCTGAC
CTCAACCCTGTGTTCATGGCCAGTGGGACCAAGCTGACCATCGTGTCCAGAGGCACCAGA
AGAACAGTTCCAATGGACCACACCTTCTTCCCCAGCTACAGAAAGACCCTGCTGGGTCCA
GAGGAGATACTGCTCTCCATTGAGATCCCCTACAGCAGGGAGGATGAGTTTTTCTCAGCA
TTCAAGCAGGCAAGCCGGAGAGAAGATGACATAGCCAAGGTGACCTGCGGCATGAGAGTC
CTGTTCCAGCCAGGAAGCATGCAGGTAAAGGAGCTAGCCCTCTGCTATGGCGGAATGGCG
GACAGAACCATCTCAGCCCTCAAGACCACGCAGAAGCAGCTGTCAAAGTTCTGGAATGAG
AAGCTGCTACAGGACGTGTGTGCAGGCCTGGCGGAAGAACTGTCCTTATCCCCAGACGCC
CCTGGAGGCATGATTGAATTCCGACGCACCCTCACCCTCAGCTTCTTCTTCAAGTTCTAC
CTGACAGTACTGAAGAAACTGGGCAAGGACTCGAAAGATAAGTGTGGTAAACTGGACCCC
ACCTACACCAGCGCCACTTTACTCTTTCAGAAACACCCTCCAGCCAACATCCAGCTCTTC
CAAGAGGTGCCCAATGGTCAGTCCAAGGAGGACACAGTGGGCCGGCCCCTGCCCCACCTG
GCCGCGGCCATGCAAGCCTCTGGGGAGGCCGTATACTGTGACGACATCCCTCGCTACGAG
AATGAGCTGTTCCTCCGGCTGGTCACCAGCACCCGGGCCCACGCCAAGATCAAGTCCATT
GATGTTTCAGAAGCTCAGAAAGTGCCAGGATTTGTTTGCTTTCTCTCTGCTGATGATATT
CCCGGGAGTAATGAAACCGGACTCTTTAATGATGAGACAGTCTTTGCGAAGGATACGGTG
ACTTGTGTTGGTCACATCATTGGTGCTGTGGTCGCTGACACCCCAGAACATGCAGAGAGA
GCTGCCCATGTAGTGAAAGTCACCTATGAGGATCTTCCTGCCATTATCACAATTGAGGAT
GCTATAAAAAATAATTCCTTTTATGGATCTGAGCTGAAGATTGAGAAAGGAGACCTCAAG
AAGGGGTTTTCAGAAGCAGATAATGTGGTTTCAGGTGAGCTGTACATTGGTGGCCAAGAC
CACTTCTACCTGGAGACTCACTGCACCATTGCTATCCCGAAAGGCGAGGAAGGGGAGATG
GAGCTCTTTGTGTCCACACAGAATGCCATGAAAACCCAGTCCTTTGTTGCAAAAATGTTG
GGGGTTCCAGTAAACCGGATTTTGGTCCGAGTGAAGAGAATGGGAGGAGGCTTTGGAGGG
AAGGAGACCCGGAGCACCCTGGTGTCTGTGGCTGTGGCCCTGGCTGCATACAAGACTGGA
CACCCGGTGCGCTGCATGCTGGATCGTAATGAGGATATGCTGATAACTGGCGGCAGACAC
CCCTTCTTGGCCAGATACAAGGTTGGCTTCATGAAGACAGGGACGATTGTGGCTCTAGAG
GTGGATCACTACAGCAATGCCGGGAACAGCCGGGACCTCTCTCACAGTATAATGGAACGA
GCTCTATTCCACATGGACAACTGCTATAAAATCCCCAACATCCGGGGCACTGGGCGGCTG
TGCAAGACCAACCTGTCCTCCAACACGGCCTTCCGGGGCTTTGGGGGGCCCCAGGCTCTG
TTCATTGCCGAGAACTGGATGAGCGAAGTTGCAGTGACCTGTGGGCTGCCTGCAGAGGAA
GTGCGGTGGAAGAACATGTACAAAGAAGGGGACCTGACCCACTTCAACCAGAGGCTTGAG
GGGTTCAGCGTGCCCAGGTGCTGGGATGAGTGCCTGAAGAGCTCTCAGTATTACGCTCGG
AAGAGTGAGGTCGACAAGTTCAACAAGGAGAATTGTTGGAAAAAGAGAGGATTGTGCATA
ATTCCTACCAAATTTGGAATAAGCTTCACAGTTCCTTTTCTAAATCAGGCAGGAGCCCTG
ATCCACGTATACACAGATGGCTCCGTGCTGGTGAGCCACGGGGGCACAGAGATGGGCCAA
GGCCTTCACACCAAGATGGTGCAGGTGGCCAGCAAAGCTCTGAAGATCCCCATCTCTAAG
ATCTATATCAGCGAGACGAGCACTAACACGGTGCCCAACTCCTCTCCCACGGCCGCCTCC
GTCAGTACCGACATCTATGGACAGGCCGTCTATGAAGCTTGCCAGACCATCCTGAAAAGG
TTGGAACCCTTCAAGAAAAAGAATCCTGATGGCTCCTGGGAAGACTGGGTCATGGCTGCC
TACCAGGATAGAGTGAGCTTATCTACCACTGGGTTTTACAGGACACCCAACCTTGGCTAC
AGCTTTGAGACCAACTCAGGGAATGCCTTCCACTATTTCACCTACGGGGTGGCTTGCTCA
GAAGTGGAAATTGACTGTTTGACAGGGGATCATAAGAACCTCCGTACAGACATTGTCATG
GATGTTGGCTCCAGTCTGAACCCTGCCATCGATATTGGACAGGTGGAAGGGGCGTTTGTC
CAGGGCCTGGGCCTCTTCACCCTGGAGGAGCTACACTATTCCCCTGAGGGGAGCCTGCAC
ACCCGCGGCCCCAGCACCTACAAGATCCCCGCGTTTGGCAGCATCCCCACAGAGTTCAGG
GTGTCCCTGCTTCGCGACTGCCCCAACAAGAAGGCCATCTATGCCTCCAAGGCGGTCGGG
GAGCCGCCCCTCTTCCTGGGCGCCTCCGTCTTCTTTGCCATCAAGGATGCCATCCGCGCG
GCTCGAGCTCAGCACACAAATAATAACACGAAGGAGCTCTTCCGGCTAGATAGCCCTGCC
ACCCCGGAGAAGATCCGCAATGCCTGCGTGGACAAGTTCACCACTCTGTGTGTCACTGGT
GCACCAGGAAACTGTAAACCCTGGTCTCTGAGGGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1332 |
| Molecular Weight
| 146790.0 |
| Theoretical pI
| 7.78 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Xanthine dehydrogenase/oxidase
MTADELVFFVNGKKVVEKNADPETTLLAYLRRKLGLRGTKLGCGEGGCGACTVMLSKYDR
LQDKIIHFSANACLAPICTLHHVAVTTVEGIGSTKTRLHPVQERIAKSHGSQCGFCTPGI
VMSMYTLLRNQPEPTVEEIEDAFQGNLCRCTGYRPILQGFRTFAKNGGCCGGNGNNPNCC
MNQKKDHTVTLSPSLFNPEEFMPLDPTQEPIFPPELLRLKDVPPKQLRFEGERVTWIQAS
TLKELLDLKAQHPEAKLVVGNTEIGIEMKFKNQLFPMIICPAWIPELNAVEHGPEGISFG
AACALSSVEKTLLEAVAKLPTQKTEVFRGVLEQLRWFAGKQVKSVASLGGNIITASPISD
LNPVFMASGTKLTIVSRGTRRTVPMDHTFFPSYRKTLLGPEEILLSIEIPYSREDEFFSA
FKQASRREDDIAKVTCGMRVLFQPGSMQVKELALCYGGMADRTISALKTTQKQLSKFWNE
KLLQDVCAGLAEELSLSPDAPGGMIEFRRTLTLSFFFKFYLTVLKKLGKDSKDKCGKLDP
TYTSATLLFQKDPPANIQLFQEVPNGQSKEDTVGRPLPHLAAAMQASGEAVYCDDIPRYE
NELFLRLVTSTRAHAKIKSIDVSEAQKVPGFVCFLSADDIPGSNETGLFNDETVFAKDTV
TCVGHIIGAVVADTPEHAERAAHVVKVTYEDLPAIITIEDAIKNNSFYGSELKIEKGDLK
KGFSEADNVVSGELYIGGQDHFYLETHCTIAIPKGEEGEMELFVSTQNAMKTQSFVAKML
GVPVNRILVRVKRMGGGFGGKETRSTLVSVAVALAAYKTGHPVRCMLDRNEDMLITGGRH
PFLARYKVGFMKTGTIVALEVDHYSNAGNSRDLSHSIMERALFHMDNCYKIPNIRGTGRL
CKTNLSSNTAFRGFGGPQALFIAENWMSEVAVTCGLPAEEVRWKNMYKEGDLTHFNQRLE
GFSVPRCWDECLKSSQYYARKSEVDKFNKENCWKKRGLCIIPTKFGISFTVPFLNQAGAL
IHVYTDGSVLVSHGGTEMGQGLHTKMVQVASKALKIPISKIYISETSTNTVPNSSPTAAS
VSTDIYGQAVYEACQTILKRLEPFKKKNPDGSWEDWVMAAYQDRVSLSTTGFYRTPNLGY
SFETNSGNAFHYFTYGVACSEVEIDCLTGDHKNLRTDIVMDVGSSLNPAIDIGQVEGAFV
QGLGLFTLEELHYSPEGSLHTRGPSTYKIPAFGSIPTEFRVSLLRDCPNKKAIYASKAVG
EPPLFLGASVFFAIKDAIRAARAQHTNNNTKELFRLDSPATPEKIRNACVDKFTTLCVTG
APGNCKPWSLRV
|
| External Links |
|---|
| GenBank ID Protein
| CAA58497.1 |
| UniProtKB/Swiss-Prot ID
| P80457 |
| UniProtKB/Swiss-Prot Entry Name
| XDH_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| X83508 |
| GeneCard ID
| XDH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
