| Identification |
|---|
| BMDB Protein ID
| BMDBP00565 |
| Secondary Accession Numbers
| None |
| Name
| Isoaspartyl peptidase/L-asparaginase |
| Synonyms
|
Not Available
|
| Gene Name
| ASRGL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Amino acid transport and metabolism |
| Specific Function
| Has both L-asparaginase and beta-aspartyl peptidase activity. May be involved in the production of L-aspartate, which can act as an excitatory neurotransmitter in some brain regions. Is highly active with L-Asp beta-methyl ester. Besides, has catalytic activity toward beta-aspartyl dipeptides and their methyl esters, including beta-L-Asp-L-Phe, beta-L-Asp-L-Phe methyl ester (aspartame), beta-L-Asp-L-Ala, beta-L-Asp-L-Leu and beta-L-Asp-L-Lys. Does not have aspartylglucosaminidase activity and is inactive toward GlcNAc-L-Asn. Likewise, has no activity toward glutamine. |
| Pathways
|
- Ammonia Recycling
- Aspartate Metabolism
|
| Reactions
|
| L-Asparagine + Water → L-Aspartic acid + Ammonia |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 29 |
| Locus
| Not Available |
| SNPs
| ASRGL1 |
| Gene Sequence
|
>927 bp
ATGAACCCCGTCGTCGTGGTCCACGGTGGCGGAGCCAGCAATATCTCCAAAGACCGGAAA
GAGCGGGTGCGCCAGGGCATCCTCAGAGCCGCCACCGTGGGTTACAACATCCTCAAGCAG
GGAGGGAGCGCCGTTGACGCGGTGGAAGGAGCCGTGACAGTGCTGGAAGACGATCCCGAC
TTCAACGCAGGTTGTGGATCTGTCTTGAACGAAAACGGGGAGGTTGAAATGGATGCCAGT
ATCATGAATGGGAAAGACCTGTCTGCAGGGGCGGTGTCTGCAGTCCGCTGTATCGCAAAT
CCCATTAAACTTGCACGGCTTGTTATGGACAAGACACCTCACTGCTTTCTGACTGACCAA
GGTGCAGCAAGATTTGCAGCAGCCAATGGGATTCCAACAATTCCTGGACAACAGCTGGTA
ACAGAAAGAAGCAGAAAACGCCTGGAAAAAGAAAAGCTTGAAAAAGATGCTCAGAAACCA
GACTGTCAGAAAAACTTGGGGACTGTGGGTGCTGTTGCCTTGGACTGCCAAGGAAACCTG
GCTTATGCAACCTCAACAGGGGGCATCGTCAACAAGATGCCGGGCCGCGTCGGGGACACG
CCGTGTGTAGGATCTGGAGGTTACGCTGACAATGACATCGGAGCTGTCTCAACGACAGGG
CACGGTGAGAGCATCCTGAAGGTGAATCTGGCCAGACTCGCGCTCTTCCACGTTGAACAG
GGAAAATCACTAGAAGAAGCTGCCAACGCATCACTGGGTCATATGAAGTCAAAGGTCAAG
GGCGTAGGTGGTATCATCATGGTCAACAAAGCAGGAGAGTGGGCGGTGAAGTGGACCTCC
ACATCCATGCCCTGGGCAGCGGCAAAGGATGGCAAGCTGCACTCGGGAATTGACTTCGGC
GACACGAGCATCATTGACCTGTCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 308 |
| Molecular Weight
| 32050.0 |
| Theoretical pI
| 7.47 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>L-asparaginase
MNPVVVVHGGGASNISKDRKERVRQGILRAATVGYNILKQGGSAVDAVEGAVTVLEDDPD
FNAGCGSVLNENGEVEMDASIMNGKDLSAGAVSAVRCIANPIKLARLVMDKTPHCFLTDQ
GAARFAAANGIPTIPGQQLVTERSRKRLEKEKLEKDAQKPDCQKNLGTVGAVALDCQGNL
AYATSTGGIVNKMPGRVGDTPCVGSGGYADNDIGAVSTTGHGESILKVNLARLALFHVEQ
GKSLEEAANASLGHMKSKVKGVGGIIMVNKAGEWAVKWTSTSMPWAAAKDGKLHSGIDFG
DTSIIDLS
|
| External Links |
|---|
| GenBank ID Protein
| AAI09622.1 |
| UniProtKB/Swiss-Prot ID
| Q32LE5 |
| UniProtKB/Swiss-Prot Entry Name
| ASGL1_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC109621 |
| GeneCard ID
| ASRGL1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
