| Identification |
|---|
| BMDB Protein ID
| BMDBP00549 |
| Secondary Accession Numbers
| None |
| Name
| 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| HIBCH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity). |
| Pathways
|
- Amino-acid degradation
- L-valine degradation
- Propanoate Metabolism
- Valine, Leucine, and Isoleucine Degradation
|
| Reactions
|
| (S)-3-Hydroxyisobutyryl-CoA + Water → (S)-3-Hydroxyisobutyric acid + Coenzyme A |
details
|
| 3-Hydroxypropionyl-CoA + Water → Hydroxypropionic acid + Coenzyme A |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| Not Available |
| SNPs
| HIBCH |
| Gene Sequence
|
>1161 bp
ATGGGGTTGCAGGGGTTGTGCAGACTCATGTCGAGGTTTAATTCATATAAAAGGACTAAT
ATCATACTGCAGCATTTGAAAATGTCTAATCACACAGATGCAGCAGCAGAAGTCCTGTTG
GAAAGAAAAGGTTGTGCAGGAGTGATAACACTAAACAGACCAAGGTTTCTGAATACCCTG
ACTCTTGGTATGATTCGGCAGATTTACGCACAGCTAAAGAAGTGGGAACAAGATCCGAAA
ACTTTCCTGATCATCATAAAGGGAGCTGGTGAAAAGGCTTTCTGTGCTGGAGGTGATATC
AGAGCACTCTCAGAAGCTAGAAATACAAACCAGAAAATGCTTCAAGATTTATTCCGAGAG
GAATATATTCTGAACAATGCCATTGATTCTTGCCAGAAACCATATATTGCACTTATTCAT
GGAATTACAATGGGTGGGGGAGTTGGTGTCTCAGTTCATGGGCAATTCCGAGTGGCTACC
GAAAAGTCTGTTTTTGCGATGCCAGAAACAGCAATAGGGCTATTCCCTGATGTGGGTGGA
GGTTATTTCTTGCCACGACTTCAAGGAAAACTTGGGTACTTCCTTGCATTAACAGGATTC
AGGCTGAAAGGAAGAGATGTGTACACAGCAGGAATTGCTACACACTTCGTAGATTTTGAA
AAGTTGGGCATGCTAGAAGAAGATTTGTTAGCCCTGAAATCTCCTTCAAAAGAAAATATT
GCAGATGTCTTAGAAACTTACCATGCAAAGTCAAAGACTGATCAAGACAAGCCTTTTATA
CTCGAGGAACACATGGACAAAATAAACAGTTGGTTCTCAGCTAATACTGTGGAACAGATT
GTTGACAATTTACAGCAAGACGGCTCATCTTTTGCCCTGGAGCAGCTGAAGGTAATTAAA
AAAATGTCTCCAACTTCACTAAAGATCACACTAAGGCAACTCATGGAGGGGTCTTCAAAG
ACCTTGCCAGAAGTATTAATTATGGAATATCGGCTGAGTCAAGCTTGTATGAAAGGCCAT
GACTTTCATGAAGGCGTTAGGGCAGTTTTAATAGATAAAGACCAGAGTCCAAAGTGGAAA
CCAGCTGACCTAAAAGAAGTTACTGATGAAGATTTGAATGATTACTTCAAATCTCTGGGA
AGTAATGATTTGAAATTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 386 |
| Molecular Weight
| 43349.0 |
| Theoretical pI
| 8.21 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
MGLQGLCRLMSRFNSYKRTNIILQHLKMSNHTDAAAEVLLERKGCAGVITLNRPRFLNTL
TLGMIRQIYAQLKKWEQDPKTFLIIIKGAGEKAFCAGGDIRALSEARNTNQKMLQDLFRE
EYILNNAIDSCQKPYIALIHGITMGGGVGVSVHGQFRVATEKSVFAMPETAIGLFPDVGG
GYFLPRLQGKLGYFLALTGFRLKGRDVYTAGIATHFVDFEKLGMLEEDLLALKSPSKENI
ADVLETYHAKSKTDQDKPFILEEHMDKINSWFSANTVEQIVDNLQQDGSSFALEQLKVIK
KMSPTSLKITLRQLMEGSSKTLPEVLIMEYRLSQACMKGHDFHEGVRAVLIDKDQSPKWK
PADLKEVTDEDLNDYFKSLGSNDLKF
|
| External Links |
|---|
| GenBank ID Protein
| AAI13275.1 |
| UniProtKB/Swiss-Prot ID
| Q2HJ73 |
| UniProtKB/Swiss-Prot Entry Name
| HIBCH_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC113274 |
| GeneCard ID
| HIBCH |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
