| Identification |
|---|
| BMDB Protein ID
| BMDBP00521 |
| Secondary Accession Numbers
| None |
| Name
| Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial |
| Synonyms
|
Not Available
|
| Gene Name
| IDH3A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Energy production and conversion |
| Specific Function
| Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. |
| Pathways
|
- Citric Acid Cycle
- Warburg Effect
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 21 |
| Locus
| Not Available |
| SNPs
| IDH3A |
| Gene Sequence
|
>1101 bp
ATGGCAGGGCCCGCGTGGATCTCCAAGGTCTCTCGGCTGCTGGGGGCATTCCACAACCAA
AAACAGGTGACCAGAGGTTTTGCTGGTGGTGTTAAGACAGTAACTTTAATTCCAGGAGAT
GGAATTGGCCCAGAAATTTCTGCTGCAGTTATGAAGATTTTTGATGCTGCCAAAGCACCT
ATTCAGTGGGAGGAGCGAAACGTCGCCGCCATTCAAGGTCCGGGAGGCAAGTGGATGATC
CCTCCAGAAGCCAAAGAGTCCATGGATAAGAACAAGATGGGCTTGAAAGGCCCTTTAAAA
ACACCAATAGCTGCTGGTCACCCATCTATGAATTTATTGCTGCGTAAAACATTTGACCTT
TATGCAAATGTCCGACCATGTGTCTCAATCGAAGGCTATAAAACCCCTTACCATGATGTA
AATATTGTCACCATTCGAGAGAACACGGAAGGAGAATACAGTGGAATCGAGCATGTGATC
GTGGATGGAGTTGTGCAGAGTATCAAGCTCATCACCGAGGCAGCGAGCAAGCGCATCGCG
GAGTTTGCATTTGAATACGCACGGAACAACCACCGGAGCAACGTCACAGCCGTGCACAAA
GCCAACATCATGCGAATGTCAGATGGGCTTTTTCTGCAAAAATGCAGGGAAGTTGCAGAA
AACTGTAAAGATATTAAATTTAATGAGATGTACCTTGATACAGTATGTTTGAATATGGTC
CAAGACCCGTCCCAGTTTGATGTTCTTGTTATGCCAAATTTGTATGGAGACATCCTTAGT
GACCTGTGTGCGGGATTGATTGGAGGTCTTGGTGTGACACCAAGCGGCAACATTGGAGCC
AACGGAGTTGCAATCTTCGAGTCGGTTCACGGGACCGCCCCGGACATTGCGGGCAAGGAC
ATGGCCAATCCCACAGCCCTCCTGCTCAGCGCCGTGATGATGCTGCGCCACATGGGGCTT
TTTGACCACGCTGCGAAGATTGAGACGGCGTGTTTTGCTACAATTAAGGATGGAAAGAGC
TTAACCAAAGATTTGGGAGGCAATTCAAAGTGCTCGGACTTCACAGAAGAAATCTGTCGC
CGAGTAAAAGATTTAGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 366 |
| Molecular Weight
| 39668.0 |
| Theoretical pI
| 7.22 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial
MAGPAWISKVSRLLGAFHNQKQVTRGFAGGVKTVTLIPGDGIGPEISAAVMKIFDAAKAP
IQWEERNVAAIQGPGGKWMIPPEAKESMDKNKMGLKGPLKTPIAAGHPSMNLLLRKTFDL
YANVRPCVSIEGYKTPYHDVNIVTIRENTEGEYSGIEHVIVDGVVQSIKLITEAASKRIA
EFAFEYARNNHRSNVTAVHKANIMRMSDGLFLQKCREVAENCKDIKFNEMYLDTVCLNMV
QDPSQFDVLVMPNLYGDILSDLCAGLIGGLGVTPSGNIGANGVAIFESVHGTAPDIAGKD
MANPTALLLSAVMMLRHMGLFDHAAKIETACFATIKDGKSLTKDLGGNSKCSDFTEEICR
RVKDLD
|
| External Links |
|---|
| GenBank ID Protein
| AAC18425.1 |
| UniProtKB/Swiss-Prot ID
| P41563 |
| UniProtKB/Swiss-Prot Entry Name
| IDH3A_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U07980 |
| GeneCard ID
| IDH3A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
