| Identification |
|---|
| BMDB Protein ID
| BMDBP00508 |
| Secondary Accession Numbers
| None |
| Name
| Inosine triphosphate pyrophosphatase |
| Synonyms
|
Not Available
|
| Gene Name
| ITPA |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. |
| Pathways
|
- Purine Metabolism
- Pyrimidine Metabolism
|
| Reactions
|
| Guanosine triphosphate + Water → Guanosine monophosphate + Pyrophosphate |
details
|
| Inosine triphosphate + Water → Inosinic acid + Pyrophosphate |
details
|
| Uridine triphosphate + Water → Uridine 5'-monophosphate + Pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 13 |
| Locus
| Not Available |
| SNPs
| ITPA |
| Gene Sequence
|
>627 bp
ATGGCGGCCTCCTTGGCCGGGAAGAAGATCGTGTTTGTCACGGGGAACGCCAAAAAGCTG
GAGGAGGTCATTCAGATTCTAGGAGATAAATTTCCGTGTACTTTGGTGGCGCAGAAAATT
GACCTGCCAGAGTACCAAGGAGAGCCTGATGAGATTTCCATTCGGAAGTGTCAGGAGGCA
GCTCGCCAGGTGCAGGGCCCTGTACTGGTAGAGGACACCTGTCTGTGCTTCAACGCCCTT
GGAGGCCTCCCTGGCCCCTACATAAAGTGGTTTCTGGAGAAGTTAAAGCCTGAAGGTCTC
CACCAGCTCCTGGAGGGGTTCCAAGACAAGTCTGCCTATGCACTCTGCACGTTCGCATTC
AGCACTGGGGACCCGAATGAGCCCGTACGCCTCTTCAGGGGCCGGACAATGGGCCGGATT
GTGGTGCCCCGTGGCTGCCGGGACTTTGGCTGGGACCCCTGCTTTCAGCCTGATGGATAC
GAGCAGACGTATGCAGAGATGCCCAAGGCTGAGAAGAACACCATTTCCCATCGCTTCCGG
GCCCTGCTTGCGTTGCAAGAATATTTTAGCAGCCTGACTCCTGGGGTCGGTGATGACCAC
CCTAGCTGGGGATCCGGAGAGGGGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 208 |
| Molecular Weight
| 23061.0 |
| Theoretical pI
| 5.36 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inosine triphosphate pyrophosphatase
MAASLAGKKIVFVTGNAKKLEEVIQILGDKFPCTLVAQKIDLPEYQGEPDEISIRKCQEA
ARQVQGPVLVEDTCLCFNALGGLPGPYIKWFLEKLKPEGLHQLLEGFQDKSAYALCTFAF
STGDPNEPVRLFRGRTMGRIVVPRGCRDFGWDPCFQPDGYEQTYAEMPKAEKNTISHRFR
ALLALQEYFSSLTPGVGDDHPSWGSGEG
|
| External Links |
|---|
| GenBank ID Protein
| AAI12689.1 |
| UniProtKB/Swiss-Prot ID
| Q2KIC5 |
| UniProtKB/Swiss-Prot Entry Name
| ITPA_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC112688 |
| GeneCard ID
| ITPA |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
