| Identification |
|---|
| BMDB Protein ID
| BMDBP00487 |
| Secondary Accession Numbers
| None |
| Name
| Golgi-resident adenosine 3',5'-bisphosphate 3'-phosphatase |
| Synonyms
|
Not Available
|
| Gene Name
| IMPAD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Carbohydrate transport and metabolism |
| Specific Function
| Exhibits 3'-nucleotidase activity toward adenosine 3',5'-bisphosphate (PAP), namely hydrolyzes adenosine 3',5'-bisphosphate into adenosine 5'-monophosphate (AMP) and a phosphate. May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Has no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3 and I(1,3,4,5)P4. |
| Pathways
|
- Myo-inositol biosynthesis
- Myo-inositol from D-glucose 6-phosphate: step 2/2
- Polyol metabolism
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| IMPAD1 |
| Gene Sequence
|
>1089 bp
ATGGCCCCCATGGGCATCCGCCTGTCCCCGCTGGGGGTGGCCGTGTTCTGCCTGCTGGGG
CTCGGCGTGCTCTACCACCTCTATTCAGGCTTCCTGGCCGGCCGCTTCAGCCTCTTTGGC
CTGGGCGGCGAGCCGGGCGGCGGGGCGGCGGGGCCCGCGGGGCCCGCGGCCTCGGCCGAC
GGGGGCACGGTGGACCTGCGCGAGATGCTGGCCGTATCGGTGCTGGCGGCCGTGCGCGGC
GGCGAGGAGGTGCGGCGCGTACGCGAGAGCAACGTCCTCCACGAGAAGTCCAAGGGGAAG
ACGCGCGAGGGAGCGGACGACAAGATGACCAGTGGAGACGTGTTGTCCAACCGCAAGATG
TTCTACCTACTCAAGACCGCCTTCCCCAGCGTGCAGATCAATACGGAGGAACATGTGGAT
GCATCTGATCAAGAGGTGATCTTGTGGGATCGGAAGATTCCTGAGGACATCCTAAAGGAA
ATAGCCACTCCCCAGGAAGTGCCGGCAGAGAGCGTCACCGTCTGGATTGACCCACTGGAT
GCCACACAGGAGTACACGGAGGATCTTCGGAAGTATGTTACTACTATGGTGTGTGTGGCT
GTAAATGGTAAACCTGTGCTAGGAGTAATACATAAACCATTTTCTGAATATACAGCCTGG
GCGATGGTAGACGGTGGATCAAATGTGAAAGCCCGCACTTCTTACAATGAGAAGACCCCA
AGGATTGTCGTGTCTCGCTCGCATTCAGGAATGGTCAAACAGGTTGCTCTTCAGACTTTC
GGAAACCAGACTACGATCATCCCAGCGGGCGGTGCTGGTTATAAAGTTTTAGCACTCTTG
GATGTGCCTGATAAGAGTCAAGAAAAAGCTGATCTATATATCCATGTGACATACATCAAA
AAGTGGGATATCTGTGCTGGCAACGCCATCTTGAAAGCCCTCGGGGGGCACATGACCACC
CTGAGTGGTGAAGAAATTAGCTACACTGGTTCCGACGGCATTGAAGGGGGGCTCCTGGCC
AGCATCAGGATGAACCATCAGGCTCTGGTCAGAAAGCTCCCGGATCTGGAGAAGACGGGA
CATAAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 362 |
| Molecular Weight
| 38924.0 |
| Theoretical pI
| 6.8 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Inositol monophosphatase 3
MAPMGIRLSPLGVAVFCLLGLGVLYHLYSGFLAGRFSLFGLGGEPGGGAAGPAGPAASAD
GGTVDLREMLAVSVLAAVRGGEEVRRVRESNVLHEKSKGKTREGADDKMTSGDVLSNRKM
FYLLKTAFPSVQINTEEHVDASDQEVILWDRKIPEDILKEIATPQEVPAESVTVWIDPLD
ATQEYTEDLRKYVTTMVCVAVNGKPVLGVIHKPFSEYTAWAMVDGGSNVKARTSYNEKTP
RIVVSRSHSGMVKQVALQTFGNQTTIIPAGGAGYKVLALLDVPDKSQEKADLYIHVTYIK
KWDICAGNAILKALGGHMTTLSGEEISYTGSDGIEGGLLASIRMNHQALVRKLPDLEKTG
HK
|
| External Links |
|---|
| GenBank ID Protein
| AAI05515.1 |
| UniProtKB/Swiss-Prot ID
| Q2KJ53 |
| UniProtKB/Swiss-Prot Entry Name
| IMPA3_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC105514 |
| GeneCard ID
| IMPAD1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
