| Identification |
|---|
| BMDB Protein ID
| BMDBP00440 |
| Secondary Accession Numbers
| None |
| Name
| Hypoxanthine-guanine phosphoribosyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| HPRT1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Nucleotide transport and metabolism |
| Specific Function
| Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). |
| Pathways
|
- IMP biosynthesis via salvage pathway
- IMP from hypoxanthine: step 1/1
- Purine Metabolism
|
| Reactions
|
| Guanosine monophosphate + Pyrophosphate → Guanine + Phosphoribosyl pyrophosphate |
details
|
| Xanthylic acid + Pyrophosphate → Xanthine + Phosphoribosyl pyrophosphate |
details
|
| Inosinic acid + Pyrophosphate → Hypoxanthine + Phosphoribosyl pyrophosphate |
details
|
|
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| X |
| Locus
| Not Available |
| SNPs
| HPRT1 |
| Gene Sequence
|
>657 bp
ATGGCGGCCCGCAGCCCCAGCGTGGTGATTAGCGATGATGAACCAGGTTATGACCTAAAT
TTATTTTGTATACCCAATCATTATGCTGAGGATTTGGAGAAGGTGTTTATTCCTCATGGA
CTAATTATGGACAGGACCGAACGGCTGGCTCGAGATGTGATGAAGGAGATGGGTGGCCAT
CACATTGTGGCCCTCTGTGTGCTCAAGGGGGGCTATAAGTTCTTTGCCGACCTGTTGGAT
TACATCAAAGCACTGAACAGAAATAGTGACAAATCCATTCCTATGACTGTGGATTTTATC
AGACTGAAGAGCTACTGTAACGACCAGTCAACAGGCGACATAAAAGTAATTGGTGGAGAT
GATCTCTCAACTTTAACTGGAAAGAATGTCTTGATTGTCGAAGATATAATTGACACTGGG
AAGACAATGCAGACTTTGCTTGCCTTGGTCAAGAAGCATAAACCAAAGATGGTCAAGGTT
GCGAGCTTGCTGATGAAAAGGACCCCTCGAAGTGTTGGATATAAACCAGACTTTGTTGGA
TTTGAAATTCCAGACAAGTTTGTTGTGGGATATGCCCTTGACTATAATGAATACTTCAGG
GACTTGAATCACGTGTGTGTCATTAGCGAAACTGGAAAAGCAAAATACAAAGCCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 218 |
| Molecular Weight
| 24498.0 |
| Theoretical pI
| 7.97 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Hypoxanthine-guanine phosphoribosyltransferase
MAARSPSVVISDDEPGYDLNLFCIPNHYAEDLEKVFIPHGLIMDRTERLARDVMKEMGGH
HIVALCVLKGGYKFFADLLDYIKALNRNSDKSIPMTVDFIRLKSYCNDQSTGDIKVIGGD
DLSTLTGKNVLIVEDIIDTGKTMQTLLALVKKHKPKMVKVASLLMKRTPRSVGYKPDFVG
FEIPDKFVVGYALDYNEYFRDLNHVCVISETGKAKYKA
|
| External Links |
|---|
| GenBank ID Protein
| AAI03249.1 |
| UniProtKB/Swiss-Prot ID
| Q3SZ18 |
| UniProtKB/Swiss-Prot Entry Name
| HPRT_BOVIN |
| PDB IDs
|
|
| GenBank Gene ID
| BC103248 |
| GeneCard ID
| HPRT1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
