| Identification |
|---|
| BMDB Protein ID
| BMDBP00423 |
| Secondary Accession Numbers
| None |
| Name
| tRNA (guanine-N(7)-)-methyltransferase |
| Synonyms
|
Not Available
|
| Gene Name
| METTL1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in tRNA (guanine-N7-)-methyltransferase activity |
| Specific Function
| Methyltransferase that mediates the formation of N(7)-methylguanine in a subset of RNA species, such as tRNAs, mRNAs and microRNAs (miRNAs). Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. Also acts as a methyltransferase for a subset of internal N(7)-methylguanine in mRNAs. Internal N(7)-methylguanine methylation of mRNAs regulates translation. Also methylates a specific subset of miRNAs, such as let-7. N(7)-methylguanine methylation of let-7 miRNA promotes let-7 miRNA processing by disrupting an inhibitory secondary structure within the primary miRNA transcript (pri-miRNA). Acts as a regulator of embryonic stem cell self-renewal and differentiation. |
| Pathways
|
- N(7)-methylguanine-tRNA biosynthesis
- TRNA modification
|
| Reactions
| Not Available |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 5 |
| Locus
| Not Available |
| SNPs
| METTL1 |
| Gene Sequence
|
>834 bp
ATGGCGGGAACCGAGACTGGGGACGCAGCAGGAACCGAGGCCCCACAGCCTCAGAAGCGC
TACTATCGGCAGCGGGCTCACTCCAACCCCATGGCGGATCATACGCTGCGCTACCCTGTG
AAACCAGAGGACATGGACTGGTCTGAGCTATACCCAGAGTTCTTCGCTCCACTGCCTCAA
AATCAGAGCCATGATGACCCAAAGGATAAGAAAGAAAAGAGAGCTCAGGCTCAAGTGGAG
TTTGCAGACATAGGCTGTGGCTATGGCGGCCTGTTAGTGGAACTGTCACCGCTGTTCCCA
GACACGCTGATTCTGGGTCTGGAGATCCGGGTGAAAGTCTCAGACTATGTACAAGACCGG
ATCCGGGCCCTGCGAGCCGCTCCTGGAGGTGGTTTCCAGAACATCGCCTGTCTCCGCAGC
AATGCCATGAAGCACCTTCCTAACTTCTTCCACAAGGGCCAGCTGACAAAGATGTTCTTC
CTCTTCCCTGACCCACATTTCAAGCGGACGAAGCACAAGTGGCGAATCATCAGTCCCACA
CTGCTGGCAGAATATGCCTACGTGCTGAGAGTTGGGGGGCTGGTGTACACCATAACTGAC
GTGCTGGAGCTGCATGAGTGGATGTGCACCCACTTTGAAGGGCACCCCTTGTTTGAGCGT
GTGCCTCTGGAGGAGCTGAGTGAAGACCCCATTGTGGGACATCTGGGCACCTCAACCGAG
GAGGGAAAGAAAGTTCTACGCAATGGAGGAAAGAACTTCCCAGCCATCTTCCGAAGAATA
CAGGATCCCGCCCTCCCGGCAGTGACTCCCACTCCTACCCCTCCTGGTCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 277 |
| Molecular Weight
| 31323.0 |
| Theoretical pI
| 7.41 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>tRNA (guanine-N(7)-)-methyltransferase
MAGTETGDAAGTEAPQPQKRYYRQRAHSNPMADHTLRYPVKPEDMDWSELYPEFFAPLPQ
NQSHDDPKDKKEKRAQAQVEFADIGCGYGGLLVELSPLFPDTLILGLEIRVKVSDYVQDR
IRALRAAPGGGFQNIACLRSNAMKHLPNFFHKGQLTKMFFLFPDPHFKRTKHKWRIISPT
LLAEYAYVLRVGGLVYTITDVLELHEWMCTHFEGHPLFERVPLEELSEDPIVGHLGTSTE
EGKKVLRNGGKNFPAIFRRIQDPALPAVTPTPTPPGH
|
| External Links |
|---|
| GenBank ID Protein
| ABM06158.1 |
| UniProtKB/Swiss-Prot ID
| Q2YDF1 |
| UniProtKB/Swiss-Prot Entry Name
| TRMB_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BT029912 |
| GeneCard ID
| METTL1 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |
